MO640 - Exercises - DNA Evolution Models, Durand-lec-notes (2014), Felsenstein (2004)- chapters 11 and 13

Exercises marked with (*) require further reading/search beyond the suggested texts.

  1. Two 41-character long DNA sequences differ in 6 positions. Admitting that their evolution follows the Jukes-Cantor model, what is the Jukes-Cantor distance between them?
  2. Two 100-character long DNA sequences differ in 15 positions, with 6 of them being transversions and 9 transitions. Admitting that their evolution follows the Kimura two-parameter model, find the transition and transversion rates multiplied by time.
  3. Find the Jukes-Cantor and Kimura distances between the following sequences:
    CTAGGCTTACGATTACGAGGATCCAAATGGCACCAATGCT
    CTACGCTTACGACAACGAGGATCCGAATGGCACCATTGCT

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