MO640 - Exercises - Genetic fine structure, Benzer 1959, Setubal and Meidanis 1997 (p. 149-159)

Exercises marked with (*) require further reading/search beyond the suggested texts.

2. Find the connected compontents in the strictly overlapping graph for the clones x probes matrix below.

0010000100
0001001000
0101101011
0010010000
0001100010
1101101010
0011111110
0000001000

Answer:

The graph is easier to construct if the clones are represented by sets of probes:

S1 = {3, 8}
S2 = {4, 7}
S3 = {2, 4, 5, 7, 9, 10}
S4 = {3, 6}
S5 = {4, 5, 9}
S6 = {1, 2, 4, 5, 7, 9}
S7 = {3, 4, 5, 6, 7, 8, 9}
S8 = {7}

Each set will be a vertex of the graph. For an edge to be drawn between any two vertices Si and Sj, the statements below must be true:

Si ∩ Sj ≠ ∅
Si ∩ Sj ≠ Si
Si ∩ Sj ≠ Sj

The graph that fulfills those conditions is:

Resulting in 4 connected components.


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