Gavin Andresen - 2011-01-23 18:45:47

From the Quora question:

@s{quotedtext} @s{quotedtext}
You can't spend 400 BTC 80 times in 1 hour.  If you control a majority of the generation you could spend them twice an an hour (assuming merchants require 6 confirmations).

So you need to divide your expected profit per hour by 40, making your ROI very, very negative.