I hate to inject gloom and doom into a fun topic like vanity bitcoin addresses... but y'all should be aware that one of my longer-term goals for the Bitcoin system is to make bitcoin addresses disappear. I hope Bitcoin software 10 years from now tells users "You're about to pay 11 micro-Bitcoins to Amazon.com" and not "2mRwtf8blahblahblah". And I'm not alone, I know Mike Hearn feels strongly about making bitcoin addresses go away for ordinary users.
If you do spent lots of time creating The World's Best system for mining vanity bitcoin addresses, please don't be upset or surprised if you find it is obsolete when "Bitcoin 2017 Turbo++ Enhanced Edition" is released.