LOCUS HSAPOA2 3360 bp DNA PRI 16-FEB-1995 DEFINITION Human gene for apolipoprotein AII. ACCESSION X04898 NID g28743 KEYWORDS apolipoprotein; apolipoprotein A-II; signal peptide. SOURCE human. ORGANISM Homo sapiens Eukaryotae; mitochondrial eukaryotes; Metazoa; Chordata; Vertebrata; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3360) AUTHORS Shelley,C.S., Sharpe,C.R., Baralle,F.E. and Shoulders,C.C. TITLE Comparison of the human apolipoprotein genes. Apo AII presents a unique functional intron-exon junction JOURNAL J. Mol. Biol. 186 (1), 43-51 (1985) MEDLINE 86089113 REFERENCE 2 (bases 1 to 3360) AUTHORS Knott,T.J., Wallis,S.C., Robertson,M.E., Priestley,L.M., Urdea,M., Rall,L.B. and Scott,J. TITLE The human apolipoprotein AII gene: structural organization and sites of expression JOURNAL Nucleic Acids Res. 13 (17), 6387-6398 (1985) MEDLINE 86016095 COMMENT An Alu repetitive element is located around the polymorphic MspI site at pos. 3033. FEATURES Location/Qualifiers source 1..3360 /organism="Homo sapiens" /db_xref="taxon:9606" misc_feature complement(59..64) /note="seq. pot. involved in steroid hormone/receptor binding" misc_feature complement(632..637) /note="seq. pot. involved in steroid hormone/receptor binding" CAAT_signal 1100..1108 TATA_signal 1148..1153 prim_transcript 1174..2507 /gene="apo AII" mRNA join(1174..1210,1380..1455,1749..1881,2277..2507) /gene="apo AII" exon 1174..1210 /gene="apo AII" /number=1 gene 1174..2507 /gene="apo AII" misc_feature 1182 /gene="apo AII" /note="5' end of cDNA" intron 1211..1379 /gene="apo AII" /number=1 exon 1380..1455 /gene="apo AII" /number=2 CDS join(1404..1455,1749..1881,2277..2394) /gene="apo AII" /codon_start=1 /product="apolipoprotein" /db_xref="PID:g671882" /db_xref="SWISS-PROT:P02652" /translation="MKLLAATVLLLTICSLEGALVRRQAKEPCVESLVSQYFQTVTDY GKDLMEKVKSPELQAEAKSYFEKSKEQLTPLIKKAGTELVNFLSYFVELGTHPATQ" sig_peptide 1404..1455 /gene="apo AII" intron 1456..1748 /gene="apo AII" /number=2 repeat_region 1711..1742 /note="(GT) 16, pot. z-DNA sequence" misc_feature 1711..1748 /gene="apo AII" /note="functional acceptor site variant sequence" exon 1749..1881 /gene="apo AII" /number=3 misc_feature 1749..1765 /gene="apo AII" /note="pro-peptide" intron 1882..2276 /gene="apo AII" /number=3 exon 2277..2507 /gene="apo AII" /number=4 polyA_signal 2487..2492 /gene="apo AII" polyA_site 2507 /gene="apo AII" BASE COUNT 904 a 849 c 832 g 775 t ORIGIN 1 cccgggaggt ggaggttgca gtgagccgag atcatgccat tacgctccag cctgagcaac 61 aagagcaaaa ctctgtctca ggaaaacaaa caaaaaaacc tgcacatata cttctgaatt 121 taaaacaaaa gttaaaaaac aaagatttct tggtctctgg tcactacctc cctcatcagc 181 tttgcgcctc cactgtcacc ctcaggaatg ttccacatac tcagcgagta tgcttggggg 241 gcaaaagggt gaaagataca aaagcttctg atatctattt aactgatttc acccaaatgc 301 tttgaacctg ggaatgtacc tctccccctc ccccaccccc aacaggagtg agacaagggc 361 cagggctatt gcccctgctg actcaatatt ggctaatcac tgcctagaac tgataaggtg 421 atcaaatgac caggtgcctt caacctttac cctggtagaa gcctcttatt cacctctttt 481 cctgccagag ccctccattg ggaggggacg ggcggaagct gttttctgaa tttgttttac 541 tgggggtagg gtatgttcag tgatcagcat ccaggtcatt ctgggctctc ctgttttctc 601 cccgtctcat tacacattaa ctcaaaaacg gacaagatca tttacacttg ccctcttacc 661 cgaccctcat tcccctaacc cccatagccc tcaaccctgt ccctgatttc aattcctttc 721 tcctttcttc tgctccccaa tatctctctg ccaagttgca gtaaagtggg ataaggttga 781 gagatgagat ctacccataa tggaataaag acaccatgag ctttccatgg tatgatgggt 841 tgatggtatt ccatgggttg atatgtcaga gctttccaga gaaataactt ggaatcctgc 901 ttcctgttgc attcaagtcc aaggacctca gatctcaaaa gaatgaacct caaatatacc 961 tgaagtgtac ccccttagcc tccactaaga gctgtacccc ctgcctctca ccccatcacc 1021 atgagtcttc catgtgcttg tcctctcctc ccccatttct ccaacttgtt tatcctcaca 1081 taatccctgc cccactgggc ccatccatag tccctgtcac ctgacagggg gtgggtaaac 1141 agacaggtat atagcccctt cctctccagc cagggcaggc acagacacca aggacagaga 1201 cgctggctag gtaagataag gaggcaagat gtgtgagcag catccaaaga ggcctgggct 1261 tcagttgtgg agagggagag agccaggttg gaatgggcag caggtaggga gatccctggg 1321 gaggagctga agcccatttg gcttcagtgt cccccaaacc cccaccaccc tcttcctagg 1381 ccgccctccc cactgttacc aacatgaagc tgctcgcagc aactgtgcta ctcctcacca 1441 tctgcagcct tgaaggtggg tgtgatatgg agagggggcc aaaagggaga atgtgctggt 1501 ggttatagct acctatctgc ctgtgctctt atatccaggt ctggcaacca aagggctcaa 1561 aaggaagatc attccctctc taaagcccag aaagcccatc caaagatctg gctggatacc 1621 tttttgggga gggggcagag agctggggtg ggtactggca gaggtatggc aggaggccag 1681 gattcactgc tgtggaccca gctgaaaaga gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt 1741 gtgggcagga gctttggttc ggagacaggc aaaggagcca tgtgtggaga gcctggtttc 1801 tcagtacttc cagaccgtga ctgactatgg caaggacctg atggagaagg tcaagagccc 1861 agagcttcag gccgaggcca agtaagtctc agggcaaggg gttcaggggc tgtggaactg 1921 tggagagaaa gaagggaaga tgagaggtcc cacagaagtc tgaacccagg ggtggggatt 1981 agggcagatt aggcttaaat tgcagagaaa aagtatttca tcacccaaag atcccacacg 2041 tctcttagat agagaggaac agcaagaact gggccttgaa tttcagtctc tagagtctgt 2101 ccctctacct agcaaaggtc ttgactctat tcctacctag gggctttgcc atgcgatgga 2161 ccaggcacta gagtttgggg acctgagtca gtctgctctg acctcccacc accaccaagg 2221 cccctgccag tgcctagggt ccctcagatt aaactctaat cccctcacct atccaggtct 2281 tactttgaaa agtcaaagga gcagctgaca cccctgatca agaaggctgg aacggaactg 2341 gttaacttct tgagctattt cgtggaactt ggaacacacc ctgccaccca gtgaagtgtc 2401 cagaccattg tcttccaacc ccagctggcc tctagaacac ccactggcca gtcctagagc 2461 tcctgtccct acccactctt tgctacaata aatgctgaat gaatccagct ctgagcctgg 2521 tatgtttggg ggactgggaa aagtagggga gtaagggagg agaagaggaa ggaaaaggaa 2581 aaatctgctt ctagaaggag agaggtttga gtgtggaggg gtgaagaaag gattgaagac 2641 acaactgatg aaaatgacag gatgagggtg ccatgattct ccaaacccag agtctcctac 2701 agcctgggca cgactctgca ggtgaacact aaagaggctt tgcattgcac aaggaactag 2761 gagaggaagg aaggattcac aaactgaatc cctcgatttc tggaggtcat agaaaatgag 2821 ggtaccctgg tggggtgcag tggctcacac ctgtaatccc tgcactttgg gaggccaagg 2881 taggtggatc acttgagatc aggagttcca gaccagccta gccaacatgg taaaaccccg 2941 tctctactaa aaatacaaaa attagccagg tgttgtggca cgtgcctgta atcccagcta 3001 ctcgggagac tgaggcatga gaatcttttg aaccggggag gcggaggttg cagtgagctg 3061 acatcgtgcc actgcactcc agcctaggtg acagagcaag actccgtctc aaaaaaaaaa 3121 aaaaaaaaaa aaaaaagaaa gtaaagaaaa aaagaaaatg agggtacccc tcataatttc 3181 ctgttagtca ttctatgaag aaaagaaagc ttcccaaggt gtcacccgtg gccctccttt 3241 cccttctgag ccaggggaac actgtgtttc cccctttccc acaataaaag acttgagttt 3301 gctcctctcc ctagaagtgc tctaatttct ccatttaaaa cctcttatct agaccaggca //