LOCUS       HSCGN3PRO    1202 bp    DNA             PRI       21-APR-1997
DEFINITION  H.sapiens promoter region of collagenase 3 gene.
ACCESSION   X81640
NID         g1945758
KEYWORDS    Collagenase-3; promoter region.
SOURCE      human.
  ORGANISM  Homo sapiens
            Eukaryotae; mitochondrial eukaryotes; Metazoa; Chordata;
            Vertebrata; Mammalia; Eutheria; Primates; Catarrhini; Hominidae;
            Homo.
REFERENCE   1  (bases 1 to 1202)
  AUTHORS   Lopez-Otin,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-SEP-1994) C. Lopez-Otin, Universidad de Oviedo, Dept
            de Biologia Funcional, Area de Bioquimica, Fac. de Medicina,
            C/Julian Claveria S/N, 33006 Oviedo, SPAIN
REFERENCE   2  (bases 1 to 1202)
  AUTHORS   Pendas,A.M., Balbin,M., Llano,E., Jimenez,M.G. and Lopez-Otin,C.
  TITLE     Structural analysis and promoter characterization of the human
            collagenase-3 gene (MMP13)
  JOURNAL   Genomics 40 (2), 222-233 (1997)
  MEDLINE   97237040
COMMENT     related sequence: X75308.
FEATURES             Location/Qualifiers
     source          1..1202
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q22"
                     /clone_lib="lambda gt10"
     promoter        303..309
                     /note="Pea-3"
     promoter        353..359
                     /note="Ap-1"
     TATA_signal     372..379
     mRNA            join(427..550,644..>889)
     exon            427..550
                     /number=1
     CDS             join(431..550,644..889)
                     /codon_start=1
                     /product="collagenase 3"
                     /db_xref="PID:e118563"
                     /db_xref="PID:g1945759"
                     /translation="MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLR
                     SYYHPTNLAGILKENAASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVG
                     EYNVFPRTLKWSKMNLTYR"
     intron          551..643
                     /number=1
     exon            644..889
                     /number=2
BASE COUNT      367 a    239 c    235 g    361 t
ORIGIN      
        1 tctagaatca gtactaagtt tctctttatg gaagtaaaca tgccatcttg atacacttat
       61 tattcgaaga agcaaaagta gatacgttct tacagaaggc aaaaaaaaaa aatttttgct
      121 aagtgaagta aaaaatgtac tactctctgc ttcttcccac agtatccata aatatgctga
      181 ggccgtttat tttgccagat gggttttgag accctgctga aacaagagat gctctcattt
      241 atatttccct caaattctac cacaaaccac actcgggagg gaaaagaaaa agtcgccacg
      301 taagcatgtt taccttcaag tgactaggaa gtggaaacct atccataagt gatgactcac
      361 cattgcaggc ctataaaagt aaaggtaatc tctgcggaaa gacaacagtc cccaggcatc
      421 accattcaag atgcatccag gggtcctggc tgccttcctc ttcttgagct ggactcattg
      481 tcgggccctg ccccttccca gtggtggtga tgaagatgat ttgtctgagg aagacctcca
      541 gtttgcagag gtagagtatc ttgccaatcc tgatgatgcg gttggtacat ctcagaaatg
      601 tccttctcct tttaaacgca gttcattttg gtgtcttttc tagcgctacc tgagatcata
      661 ctaccatcct acaaatctcg cgggaatcct gaaggagaat gcagcaagct ccatgactga
      721 gaggctccga gaaatgcagt ctttcttcgg cttagaggtg actggcaaac ttgacgataa
      781 caccttagat gtcatgaaaa agccaagatg cggggttcct gatgtgggtg aatacaatgt
      841 tttccctcga actcttaaat ggtccaaaat gaatttaacc tacaggtaaa tcataggcta
      901 tctttctttc atatttgtta gccttttctt gtagtattaa atgtctaata ttaagtaggc
      961 cttattattt aattggcagt taaattccag aatagcttta atatggttgc cgagaatacc
     1021 tcataacatc tattattgtt acattaactc agcattattt tttagtgggc atctcaaagt
     1081 atttctttta gagatgaaat caaaagagaa ataaaagtag gttaaagaaa atttgcaaac
     1141 atagtacatt aggtgtattt attacaacag tgctcaagat gaagagttcc actctttcta
     1201 ga
//