LOCUS HSCKBG 4200 bp DNA PRI 24-APR-1993 DEFINITION Human gene for creatine kinase B (EC 2.7.3.2). ACCESSION X15334 NID g29962 KEYWORDS creatine kinase; creatine kinase B. SOURCE human. ORGANISM Homo sapiens Eukaryotae; mitochondrial eukaryotes; Metazoa; Chordata; Vertebrata; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 4200) AUTHORS Mariman,E.C.M. TITLE Direct Submission JOURNAL Submitted (23-MAY-1989) Mariman E.C.M., University of Nijmegen, Dept of Human Genetics, Geert Grooteplein Z18, 6525 GA Nijmegen, Netherlands REFERENCE 2 (bases 1 to 4200) AUTHORS Mariman,E.C., Schepens,J.T. and Wieringa,B. TITLE Complete nucleotide sequence of the human creatine kinase B gene JOURNAL Nucleic Acids Res. 17 (15), 6385 (1989) MEDLINE 89366665 REFERENCE 3 (bases 1 to 4200) AUTHORS Mariman,E. and Wieringa,B. TITLE Expression of the gene encoding human brain creatine kinase depends on sequences immediately following the transcription start point JOURNAL Gene 102 (2), 205-212 (1991) MEDLINE 91340154 COMMENT The sequence overlaps with that reported by Mariman et. al. in Genomics 1:126-137(1987)J03036 and by Daouk et. al. in J. Biol. Chem. 263:2442-2446(1988)J03531. Data kindly reviewed (13-NOV-1989) by Mariman E.C.M. FEATURES Location/Qualifiers source 1..4200 /organism="Homo sapiens" /db_xref="taxon:9606" /clone="CK3-1" /tissue_type="brain" /clone_lib="EMBL3" /map="chromosome 14q32.3" CAAT_signal 724..728 TATA_signal 742..749 CAAT_signal 754..758 exon 808..875 /number=1 mRNA join(808..875,1136..1340,1464..1618,1691..1823,2208..2379, 3050..3173,3331..3520,3600..4075) intron 876..1135 /number=1 exon 1136..1340 /number=2 CDS join(1148..1340,1464..1618,1691..1823,2208..2379, 3050..3173,3331..3520,3600..3778) /EC_number="2.7.3.2" /codon_start=1 /product="creatine kinase B" /db_xref="PID:g29963" /db_xref="SWISS-PROT:P12277" /translation="MPFSNSHNALKLRFPAEDEFPDLSAHNNHMAKVLTPELYAELRA KSTPSGFTLDDVIQTGVDNPGHPYIMTVGCVAGDEESYEVFKDLFDPIIEDRHGGYKP SDEHKTDLNPDNLQGGDDLDPNYVLSSRVRTGRSIRGFCLPPHCSRGERRAIEKLAVE ALSSLDGDLAGRYYALKSMTEAEQQQLIDDHFLFDKPVSPLLLASGMARDWPDARGIW HNDNKTFLVWVNEEDHLRVISMQKGGNMKEVFTRFCTGLTQIETLFKSKDYEFMWNPH LGYILTCPSNLGTGLRAGVHIKLPNLGKHEKFSEVLKRLRLQKRGTGGVDTAAVGGVF DVSNADRLGFSEVELVQMVVDGVKLLIEMEQRLEQGQAIDDLMPAQK" intron 1341..1463 /number=2 exon 1464..1618 /number=3 intron 1619..1690 /number=3 exon 1691..1823 /number=4 intron 1824..2207 /number=4 exon 2208..2379 /number=5 intron 2380..3049 /number=5 exon 3050..3173 /number=6 intron 3174..3330 /number=6 exon 3331..3520 /number=7 intron 3521..3599 /number=7 exon 3600..4075 /number=8 polyA_signal 3952..3957 BASE COUNT 586 a 1443 c 1477 g 694 t ORIGIN 1 gatcagtttt tttttttaat cgcacttatg cttattgttt attagcgttt cctcccatct 61 ttgcctgaag tctccgggga ctgcctttgg gggtcgggta aacttgtccc ctgcgaagag 121 ggcccagggt tggggtctgg aaactccgag gctgcacttg ccagcggcct cttaaggcca 181 cagcgtcccc gtggtttctg gctcgcagcc ccccgagacc caggacttgt ccaaggtcag 241 ggcaccgcgg gtgcccccgg gctgggccgc agcagactgc gcttcccgcg cgccttcgct 301 ttgcaccagg atcgcccagg aaatgcctgc gggcaccttg aggaaggtcg gcggctccgg 361 gccagctcgc actggccggg gtggggcggg ggccgtacct gctgcggaag ccccgaaagc 421 tttcgcccgg cccctcgccg ccgccgcggg ggctggctgg actaggcggg caggctcgag 481 gatgcggatg aacccaagcg tcctcgagtg cccggaggct ctccgcctca gtttcccgcc 541 cagaggcaag ggcgtgcgag gggatccaga tatccaagga cctgaggttt cggcctcgag 601 gtcttgggcg ggggactggg caggctgcgc ggggtcccag cgaggggaca gctcgggtgg 661 gcggccaggg tgttgggggc tgcgggcggc ggacaaagcg gcggcaccac cccgcggcgc 721 gggccaatgg aatgaatggg ctataaatag ccgccaatgg gcggcccgcg ttgtgcccct 781 taagagccgc gggagcgcgg agcggccgct gttcgcctgc gtcgctccgg gagctgccga 841 cggacggagc gcccccgccc ccgcccggcc gcccggtgag tgggcccggg ggccgggggc 901 gtccgcgccc gggctagggg cgctgcgagc aaagggggcg cgtcgcctgg agcgcgcgcc 961 ggaccggccg ggggtccccg gcgatgatgg cgctccccgc gcgcgctgcg gaccccgctg 1021 accttggccg cgtcccgggg ggcgccgggg ggcccggcgg cgggggcctg agtggtacgc 1081 gggagcccgg gaaccccggc gtgccggtcc cctctgaccc cgcgtctccc cgcagcccgc 1141 cgccgccatg cccttctcca acagccacaa cgcactgaag ctgcgcttcc cggccgagga 1201 cgagttcccc gacctgagcg cccacaacaa ccacatggcc aaggtgctga cccccgagct 1261 gtacgcggag ctgcgcgcca agagcacgcc gagcggcttc acgctggacg acgtcatcca 1321 gacaggcgtg gacaacccgg gtacgcgacc cctcggggcc ggggtcccgg ccccccctcc 1381 ccccgcgcag ccgcagggtc ctcagcagcg cgctcgggcc cggcagtgac gtcactgtcc 1441 ccgtcccgcg ccccctcccc caggccaccc gtacatcatg accgtgggct gcgtggcggg 1501 cgacgaggag tcctacgaag tgttcaagga tctcttcgac cccatcatcg aggaccggca 1561 cggcggctac aagcccagcg atgagcacaa gaccgacctc aaccccgaca acctgcaggt 1621 gcggggctgc gggcgggccg ggcgggcggg gccggggtct tcgggcgctc actcccgtct 1681 cgcctcccag ggcggcgacg acctggaccc caactacgtg ctgagctcgc gggtgcgcac 1741 gggccgcagc atccgtggct tctgcctccc cccgcactgc agccgcgggg agcgccgagc 1801 catcgagaag ctcgcggtgg aaggtagggg ccgggcgggc cgaggggcgg cggcggccgc 1861 gtccccctcc cggcgcggtc cccgcccgct tttgtttacg tcgcccggga gcggcagccg 1921 ccgtcgcgct cttatctgcg cgcgcccggg ttcagtttcc cggacccacc gagggacgga 1981 ggcccagccc ccgcgcccac agcggcctgg ggcccaggga gggcgggtcc tggcgcgggg 2041 tcaccgcctg ggaccgtcgc ccgggccgtg aggactggac gcccgcagat ccgggcgggt 2101 ggggccctct gacgtccccc gaggtggggc acgggggcgg gcgggtccgc gctgcgggct 2161 ggaggggcgg gcgcgggagc ccagcgtcct gagcgcaccc ctcgcagccc tgtccagcct 2221 ggacggcgac ctggcgggcc gatactacgc gctcaagagc atgacggagg cggagcagca 2281 gcagctcatc gacgaccact tcctcttcga caagcccgtg tcgcccctgc tgctggcctc 2341 gggcatggcc cgcgactggc ccgacgcccg cggtatctgg tgcgtgtccc tctgcgccct 2401 ctcgcggcgt cctccctccc cgctacctcc gctttccctc tcgcccccct cgcgggggtg 2461 gggcccctcg cggcgaggag gaggaggagg aggagggagg ggccggccgc gctccgggtc 2521 tgggttccgt gccgcgcctc ctcctgcgcc ggtgaccttg gccgagcagg tgcgttaagg 2581 gactgggccc cggcccgtgg gggctcagga ctcagcaaca cctccccacc ccgagacgtg 2641 aggtgggggc ggggctctct ggcgcctctc cccgacggcc ctgggagctg gagctctttg 2701 ttttcttttc tcactcctcc gccgctggga ttctaccagg ggctggtgac gccaaagctt 2761 ctccaggggc agggctccta cccccactgt ggggggcggg tcgggctgtc ctggcggtcc 2821 ctggccccgc cccacctcgg gccacagcgc atgatggcag ctggggttct cctgctgtga 2881 ggcgtcccgg ttcccccgcc cgccccgtgt tggcgggtgg agtcttggca gcagcctcca 2941 ctcctgggca tggcagggag cagcacctca gggacttggg aagttccttt ggtctggggg 3001 cggcctgggg cttttttctg ggtatgccct gagaccagcc ctcccgcagg cacaatgaca 3061 ataagacctt cctggtgtgg gtcaacgagg aggaccacct gcgggtcatc tccatgcaga 3121 aggggggcaa catgaaggag gtgttcaccc gcttctgcac cggcctcacc caggtgccag 3181 ggacggggca ggcccagacc ccagggcccc agcagggatg tgggtgcccc agcatcagtc 3241 cccccggggg atttccggca ctggggagtc tcagggcctg taggggtttc aggcaggcct 3301 tctccctcat accctcttct ccgtctgcag attgaaactc tcttcaagtc taaggactat 3361 gagttcatgt ggaaccctca cctgggctac atcctcacct gcccatccaa cctgggcacc 3421 gggctgcggg caggtgtgca tatcaagctg cccaacctgg gcaagcatga gaagttctcg 3481 gaggtgctta agcggctgcg acttcagaag cgaggcacag gtgagcaggg caggtgctgc 3541 ggcttcccgt ggcctttggg cagccctgtt tcctccgccc tgacttgctg tctccccagg 3601 cggtgtggac acggctgcgg tgggcggggt cttcgacgtc tccaacgctg accgcctggg 3661 cttctcagag gtggagctgg tgcagatggt ggtggacgga gtgaagctgc tcatcgagat 3721 ggaacagcgg ctggagcagg gccaggccat cgacgacctc atgcctgccc agaaatgaag 3781 cccggcccac acccgacacc agccctgctg cttcctaact tattgcctgg gcagtgccca 3841 ccatgcaccc ctgatgttcg ccgtctggcg agcccttagc cttgctgtag agacttccgt 3901 cacccttggt agagtttatt tttttgatgg ctaagatact gctgatgctg aaataaacta 3961 gggttttggc ctgcctgcgt ctgagtggtg cctctccttt cccagggggg agggggaagg 4021 gcagcagcca ggccccagga gtcttgagtc ctgggcctgc tgtgggcctc gccttctgtg 4081 agatgggaca agagccagga ggtggccact ctgttctgcc tgccctacct agtccatggg 4141 ccccttccct cgtgtctatc gggctgtgca ggcaggaaca tgggagagag cgagggagga //