LOCUS HSCKIIBE 5917 bp DNA PRI 24-MAR-1995 DEFINITION Human gene for casein kinase II subunit beta (EC 2.7.1.37). ACCESSION X57152 NID g29968 KEYWORDS casein kinase; cytoplasmic protein; nuclear protein. SOURCE human. ORGANISM Homo sapiens Eukaryotae; mitochondrial eukaryotes; Metazoa; Chordata; Vertebrata; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 5917) AUTHORS Pyerin,W. TITLE Direct Submission JOURNAL Submitted (09-JAN-1991) W. Pyerin, DEUTSCHES KREBSFORSCHUNGSZENTRUM, BIOCHEMICAL CELL PHYSIOLOGY, INST OF EXPERIMENTAL PATHOLOGY, GERMAN CANCER RESEARCH CENTER, IM NEUENHEIMER FELD 280, D-6900 HEIDELBERG F R G REFERENCE 2 (bases 1 to 5917) AUTHORS Voss,H., Wirkner,U., Jakobi,R., Hewitt,N.A., Schwager,C., Zimmermann,J., Ansorge,W. and Pyerin,W. TITLE Structure of the gene encoding human casein kinase II subunit beta JOURNAL J. Biol. Chem. 266 (21), 13706-13711 (1991) MEDLINE 91310643 REFERENCE 3 (bases 1 to 5917) AUTHORS Walter,P. TITLE Human casein kinase II: structures, genes expression and requirement in cell growth stimulation JOURNAL Adv. Enzyme Regul. 34, 225-246 (1994) MEDLINE 95028755 FEATURES Location/Qualifiers source 1..5917 /organism="Homo sapiens" /db_xref="taxon:9606" GC_signal 328..332 GC_signal 414..418 CAAT_signal 481..487 GC_signal 589..593 exon 683..1011 /note="casein kinase II subunit beta" /number=1 mRNA join(683..1011,1623..1705,2672..2774,3344..3459, 3906..3981,4128..4317,4645..4875) /note="casein kinase II subunit beta; major start sites" /evidence=experimental GC_signal 698..702 mRNA join(715..1011,1623..1705,2672..2774,3344..3459, 3906..3981,4128..4317,4645..4875) /note="casein kinase II subunit beta; major start site" /evidence=experimental CAAT_signal 759..765 mRNA join(795..1011,1623..1705,2672..2774,3344..3459, 3906..3981,4128..4317,4645..4875) /note="casein kinase II subunit beta; minor start site" /evidence=experimental intron 1012..1622 /number=1 exon 1623..1705 /note="casein kinase II subunit beta" /number=2 CDS join(1634..1705,2672..2774,3344..3459,3906..3981, 4128..4317,4645..4735) /EC_number="2.7.1.37" /note="protein kinase" /codon_start=1 /product="casein kinase II subunit beta" /db_xref="PID:g29969" /db_xref="SWISS-PROT:P13862" /translation="MSSSEEVSWISWFCGLRGNEFFCEVDEDYIQDKFNLTGLNEQVP HYRQALDMILDLEPDEELEDNPNQSDLIEQAAEMLYGLIHARYILTNRGIAQMLEKYQ QGDFGYCPRVYCENQPMLPIGLSDIPGEAMVKLYCPKCMDVYTPKSSRHHHTDGAYFG TGFPHMLFMVHPEYRPKRPANQFVPRLYGFKIHPMAYQLQLQAASNFKSPVKTIR" intron 1706..2671 /number=2 repeat_region 1934..2212 /rpt_family="ALU" exon 2672..2774 /note="casein kinase II subunit beta" /number=3 intron 2775..3343 /number=3 exon 3344..3459 /note="casein kinase II subunit beta" /number=4 intron 3460..3905 /number=4 exon 3906..3981 /note="casein kinase II subunit beta" /number=5 intron 3982..4127 /number=5 exon 4128..4317 /note="casein kinase II subunit beta" /number=6 intron 4318..4644 /number=6 exon 4645..4875 /note="casein kinase II subunit beta" /number=7 BASE COUNT 1363 a 1452 c 1672 g 1430 t ORIGIN 1 gatctgtcgg ttggggtcct acttttacat aacgccccca caatgccctt cgccttcctc 61 aacgtggccc ccgctccaag cccattttct ggagccagga atccactctg tgggttagga 121 aaggccctca ggaggcggag ggaaacctgt ggaatgccga gaagccgtgt aatgaaataa 181 cggtcacggc ctggcccctc accattactc tgaccagggt tcgaaggtca cacttagagc 241 ctaaggggaa atggagaagt gcaaagggac gagcagaatg gctggcacca cctcaggtta 301 gcgcactggg acgttccagt tctcacaccg cccaccccac cccacccaag tcctacgcac 361 ggagccaagc cgcacctctc ccctcatgag gcaggagccc cggaggaaac agtacgcccg 421 tcaagggtct ctggcgggac tgattcgcac taggggccca acaggcaata aggacccagc 481 ggattggccg aggataggcc agtcccctgg gcagcagcgc cgcgccggga ctagagggga 541 acgtgaggag agctgcggaa agagatccag cctggctccc tcctttcccc gccctaagtc 601 agcctcttca cccagtgagc acaaaactgt attgcccaga ctcccgggcc ccgaacgcca 661 tacctggctt ccgcttccgg tggcttctcg ttgtgccccg cccgcaagcg ccctcctccg 721 ggccttcgtg acagccaggt cgtgcgcggg tcatcctggg attggtagtt cgctttctct 781 catttagcca gtttctttct ctaccgggga ctccgtgtcc cggcatccac cgcggcacct 841 gacccttggc gcttgcgtgt tgccctcttc cccaccctcc ctaatttcca ctccccccac 901 cccacttcgc ctgccgcggt cgggtccgcg gcctgcgctg tagcggtcgc cgccgttccc 961 tggaagtagc aacttcccta ccccacccca gtcctggtcc ccgtccagcc ggtgagtctg 1021 aagtcgtcgc tgctccgagt cccttgtcgc tgggagcggc acatggggtc tccggacttt 1081 gatgtggggc gggggaggaa gcgaccaggt ccggcacgaa ggagggagag gtggcctgag 1141 gagcggaggg gggatgtgtg gattccggtg aaagggacct gacaatcgcc cccaacccgt 1201 gagaaaagga ggagcccagt tcttgcttga gaatgataaa cttggaaacc cttgggaaag 1261 gcgtgggggt catgcagaga cttgtattgg tagggagcct gagtcgaggt ccctgccgga 1321 gttgacacag aggagagagg gccctggcct tcgggagctc cagggatgtg ggtcgggctg 1381 gtgggtcaaa gtatctgttg gcttctttca agtggtggga ccccaaagaa tgtttaactt 1441 caaagaaaag gggctgagat gtaaattaga ggagctggag aggagtgctt cagagtttgg 1501 gttgctttaa gaaagggtgg ttccgaattc tcccgtggtt ggagggccga atgtgggagg 1561 agggaggata ccagaggcag ggaaggagaa cttgagcttt actgacactg ttctttttct 1621 agctgacgtg aagatgagca gctcagagga ggtgtcctgg atttcctggt tctgtgggct 1681 ccgtggcaat gaattcttct gtgaagtgag ttctcttcaa cctccctact tgccagcttc 1741 acatatcttc ccaccagacg ttccttcaca tattccactt ctacactgtt ctcttacatg 1801 ctatttgaaa acttcctatc agcaaagagt cccccctata aaccccgacg aacctgtgct 1861 aaagtggcaa aactggggcc caagtcctga gtctgccacc gtccagcaat ataacgttgg 1921 gctagtcaat ttgtgtcttt ttcttttttt tgagactggg tctcactctg tcaccgaggc 1981 tggagggtag tggtgcgatc tcggcttact gccacctctg cctcccaggt tcaagcgatt 2041 ctcctgctcc agcctcccaa gtagctggga ttacaagtgc ctgccaccat gcctggctaa 2101 tttttgtatt tttagtagag acagggtttc actatgttgg caaggctggt ctcgaactcc 2161 agacctcagg gtgatctgcc tgcctcgggc ctcccaaagt gctgggatta caggcgtgag 2221 cattgcgccc ggcctgtatc ttttgttact aaagtggcac tgctagtact tgtctcaggt 2281 ggcctttagg aaaactgaaa tgctacacat tgaaatgttt tgttcagaaa ccatgctgtt 2341 cagcttccac cttccttagc cagctgagag gacaaaactg gttcctagag acgggataca 2401 ggagtggagt agggacaaag atcttggaaa agaatgtcta agaaaaagat tgctgtatct 2461 acttatcctt agaaaagaaa agccaaagct tttatgggag agagtgtagg tgaactaggg 2521 agagacacaa gtacttctgc tgagttggga gtgagaaaca agcacaacag atgcagttgt 2581 gttgatgata aggcatcact tagagcattt tgcccaggtc aaagatgagg attttgatat 2641 gggttccctc ttggcttcca tgtcctgaca ggtggatgaa gactacatcc aggacaaatt 2701 taatcttact ggactcaatg agcaggtccc tcactatcga caagctctag acatgatctt 2761 ggacctggag cctggtgagg caccctcagg gttgttttgt gtgtgtgcgt gcactatttt 2821 tctcttcaaa tctctattca cttgcctgaa ttttgccaaa tttcctttgg ttctctgatt 2881 tctttaaccc caaattcatg ctttattttg atcctccacc tgactcttgt ctagttttgt 2941 gacgtatatc acttgttctc atgttttcta aatccgcaat tcagacctat tccaaaatgc 3001 gtttcctcag ggtctggttt gttgtctgtt tctcctgctt tgcaccttcc agtctagagt 3061 ttcatcttct gcattgacat tgttgcagtt atgtattgag gagggagttg ggagggagag 3121 caaggagcag aggctgaaaa ggtgtgaggg gaaggcagag ctgtcttcgt ttgatgcaag 3181 ggtcagaagc ccaggtttct gggtcccatg cccagatgtt ggatggggta aggcccaaaa 3241 gtaggtgcta ggcaaactga atagcccgca gcccctggat atgggcaggg cacctaggaa 3301 agctgaaaaa caagtagttg catttggccg ggctgtggtt cagatgaaga actggaagac 3361 aaccccaacc agagtgacct gattgagcag gcagccgaga tgctttatgg attgatccac 3421 gcccgctaca tccttaccaa ccgtggcatc gcccagatgg tgaggcctct ctgctcctac 3481 ctgcctcctt ctgagcagta agagacacag gttcctgcag caagaagtca tgtttaagcc 3541 ctgtttaagg aagctagctg agaagagggg aagaacccca gaacttgggc ctgggaattg 3601 aattctgatt gggggtcatc ctgaagggat tgttttcagg gagggagaca gaccttgaat 3661 cagagagttg tgatagactg cctcttcctc aaggaacaaa caacaaatgg ctctgatggt 3721 ttgtagccct gccctaattt ggaagaaagg caacacagaa gtttgagagc ccatctagtc 3781 cagagaaggg ggcctctgga cagagttgga aggagtgccg acagagttgg tatgggttgg 3841 gctgcgaagg gagttgcctc ttctttacat ctacctgcca accccttcca ttgtattcac 3901 ctcagttgga aaagtaccag caaggagact ttggttactg tcctcgtgtg tactgtgaga 3961 accagccaat gcttcccatt ggtgagtgtt gaagaaggga aaggaaagca ccgtgtggca 4021 gtcttatggg aaggagttgg ggctcaacac attggagcct gagtcctgag gggaggttag 4081 gtaggaatag ggggatacct ggcctgctga gtctggctgt ctcccaggcc tttcagacat 4141 cccaggtgaa gccatggtga agctctactg ccccaagtgc atggatgtgt acacacccaa 4201 gtcatcaaga caccatcaca cggatggcgc ctacttcggc actggtttcc ctcacatgct 4261 cttcatggtg catcccgagt accggcccaa gagacctgcc aaccagtttg tgcccaggta 4321 gggagcaggg agagtcatta agggtcaaag gaaaggccca agatccccca gagaggggag 4381 gacagggcat ggccctttct tgaggtctgc ttctcccaga atcagggcat ctccctgctg 4441 agtgactgtg ggaaagttat ttgattatct gtgcttgagt taccttattg tagaatgttc 4501 ttgagctgag aagttgggaa ccacgaggct ttagctctga gcaggtccat agaggagctc 4561 aggtggggag gtgggaatgc aggtgactgg cagggcctgg atggggctca tgctgctgcc 4621 tctctgacct ctgccctggc ctaggctcta cggtttcaag atccatccga tggcctacca 4681 gctgcagctc caagccgcca gcaacttcaa gagcccagtc aagacgattc gctgattccc 4741 tcccccacct gtcctgcagt ctttgtcttt tcctttcttt tttgccaccc tttcaggaac 4801 cctgtatggt ttttagttta aattaaagga gtcgttatcg tggtgggaat atgaaataaa 4861 gtagaagaaa aggccatgag ctagtctgct ggtgcttgct gttggggaag ggaaggtgat 4921 ggtgtgttgg actccagggg ccctcatggc ccagcccacc ctccccagat tgaaaaccag 4981 gacagatttg tgctcagtgg attgggtggt gtttttagta tggagcagaa cagaattcct 5041 aggactgcgt gtgatgaaat gcaaggtcaa aaggaaaaga caaagcatat ttcaaagatg 5101 agaaatattt gtttggatat ctatgactgt ctgtttatac tgtaaggggc ttaatcagca 5161 gctccatctt ttagttttag ttctaaagga aaagtagcct aaagtcagta taactaaagg 5221 gtggaacgag gtgggacaag gtccggaatt gctgctcagt gatgtgtgtg tgcctgccgc 5281 tggtggagct gagactgctc actctcagaa ggatggggat gcttgatttc ctggccaggt 5341 tgtcccagca cagtggggat tggccctgtt gtatgacgaa gacagcacat ggtggcagag 5401 atagatacta acccatggac tttccaaggg agggaatagg tctttggagg gtatgcaaga 5461 caaaggtaga cactggataa agaacccggt agtgcccagg tattacccca tctgggccat 5521 tactcccaca ctcaggaacc agacgttgtg ggtgaggaca tgctgtccct cctgccaagt 5581 aataacttcc ttcccagcca ggatcctgcc ccaagtagga atatagctct gcatttacag 5641 cagctcctgc tcagaccttg tcaaaaccac cctgcagctt aggattaagg agcatggtca 5701 caggaaggtg gggtttcagg gcatcccctc aggaactgcc catctcccca gaattccaaa 5761 atgaaggtcc atatgcttgt aggtgtgctg gtcatggtgg gctcacagta ggaaagggta 5821 agtggggccc aggggcaggg agggaggaag gggtaactga gtccaggaag ggggtggagc 5881 gtggccatgg aaatcgggct ccacggccca gggatgg //