LOCUS HSCST3G 7292 bp DNA PRI 01-DEC-1993 DEFINITION Human CST3 gene for cystatin C. ACCESSION X52255 S38807 NID g30257 KEYWORDS cystatin C; cysteine proteinase inhibitor. SOURCE human. ORGANISM Homo sapiens Eukaryotae; mitochondrial eukaryotes; Metazoa; Chordata; Vertebrata; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 7292) AUTHORS Abrahamson,M. TITLE Direct Submission JOURNAL Submitted (22-MAR-1990) Abrahamson M., Dept of Clinical Chemistry, University Hospital / Lund, S-221 85 Lund, Sweden REFERENCE 2 (bases 1 to 7292) AUTHORS Abrahamson,M., Olafsson,I., Palsdottir,A., Ulvsback,M., Lundwall,A., Jensson,O. and Grubb,A. TITLE Structure and expression of the human cystatin C gene JOURNAL Biochem. J. 268 (2), 287-294 (1990) MEDLINE 90303202 REFERENCE 3 (bases 1 to 7292) AUTHORS Abrahamson,M., Jonsdottir,S., Olafsson,I., Jensson,O. and Grubb,A. TITLE Hereditary cystatin C amyloid angiopathy: identification of the disease-causing mutation and specific diagnosis by polymerase chain reaction based analysis JOURNAL Hum. Genet. 89 (4), 377-380 (1992) MEDLINE 92316504 COMMENT See for mRNA sequence. FEATURES Location/Qualifiers source 1..7292 /organism="Homo sapiens" /db_xref="taxon:9606" /clone="lambda C3" /cell_type="leukocyte" /clone_lib="Charon 4A" /chromosome="20" GC_signal 352..357 GC_signal 939..944 TATA_signal 960..965 prim_transcript 1010..5287 mRNA join(1010..1327,3580..3693,4948..5287) exon 1010..1327 /number=1 CDS join(1085..1327,3580..3693,4948..5031) /codon_start=1 /product="cystatin C" /db_xref="PID:g296643" /db_xref="SWISS-PROT:P01034" /translation="MAGPLRAPLLLLAILAVALAVSPAAGSSPGKPPRLVGGPMDASV EEEGVRRALDFAVGEYNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKT QPNLDNCPFHDQPHLKRKAFCSFQIYAVPWQGTMTLSKSTCQDA" sig_peptide 1085..1162 mat_peptide join(1163..1327,3580..3693,4948..5028) /product="cystatin C" intron 1328..3579 /number=1 exon 3580..3693 /number=2 intron 3694..4947 /number=2 exon 4948..5287 /number=3 polyA_signal 5271..5276 BASE COUNT 1508 a 1881 c 2316 g 1587 t ORIGIN 1 tctagacctt gaccaaatgc tcacggatac tcaggacctc cgaagactcc ggaaggccga 61 gacctctatc tttccctttt ctgaggaaat gaagctaggg ggtcgtatgc ttttagggcc 121 cagggggcct tgacacctct ctggagggca gggtgaccta agcttgggag gagggacagg 181 tctttgggaa gagatggagc tgagggggtg gagtgggtag aaggggggca taggtgtgga 241 aggggtgggg gaagaggggc caggagtggg gtgagaagag gggaaagaag aggataggag 301 ggacagggac agggagaggc caggaatggg taggaaggga agacagagga ggggcgggac 361 gagggagggg cgatgaagag gggccgagct ggggtggggg cgaagtggga gcaaggacag 421 gagtggagga gggagatgag gggcatggga ggcggtgtct gggggttgaa aggggaaagg 481 gacagaggag aaggagcctg aagagtggcg gcatggaggg gcccgaagtg gggaggtggg 541 aatggtcgga tggatgggga ggaatgggga ggataggaga ggcaggggag gctggaagac 601 agtaggagag gagggggagg ggaggggagg ggatggatgg gaatggatag ggaaggccag 661 ggagactggg gggccagggg aggaggggag ggagagggga ggcgggaagg gagaggagag 721 gccgggaggg gctgggaggg gagggaaggg gatggatggg gaaggacagg gaagcctgga 781 ggggcagggg aggctgggat gggaggagac tgatagggag ggacctggag gcggggagag 841 gcaggggagg cggggagagg caggggaggc ggggagggag aagggaggtg ggagggacga 901 ggcgttccgg aaaagggagt gcaggccgcg gtggggtggg gcggcgaagg ccggaaggga 961 taaaaccgca gtcgccggcc tcgcggggct cacggcctcg cctcggtatc gcagcgggtc 1021 ctctctatct agctccagcc tctcgcctgc gccccactcc ccgcgtcccg cgtcctagcc 1081 gaccatggcc gggcccctgc gcgccccgct gctcctgctg gccatcctgg ccgtggccct 1141 ggccgtgagc cccgcggccg gctccagtcc cggcaagccg ccgcgcctgg tgggaggccc 1201 catggacgcc agcgtggagg aggagggtgt gcggcgtgca ctggactttg ccgtcggcga 1261 gtacaacaaa gccagcaacg acatgtacca cagccgcgcg ctgcaggtgg tgcgcgcccg 1321 caagcaggtg cgtgccgccc cccgcagggt ccgaagcccc ggccccgccg tcccagcctc 1381 cccccgcgct gctcccggac cccgtgctgc tcctctccgg cgcctgggct tctcacccgg 1441 accctgttcc cggtcttcgc tgtcaccccc gagcccttgg cgggcgtgtc cgggaatgcc 1501 ctgagtctgg cctggcctgg aaccgcacgg acacgtcagg tccgcgcccg gcgcctaaga 1561 tcagcttcca ggagccagct cgagctgcgc cgcagcgcgg gggcaggcac aggacgtccc 1621 acacagctct gtcccgacct cctgggacgc tgggctccgg gtgcgctgct gaatacgcag 1681 gagaaggaaa aacagagccc ctcatctggc tgcctccttg ttcttccacc aaataatttt 1741 taagcacttt tgtttctttt aactttttat tctcccgtaa tttcagactt acagagcagc 1801 tgcaaaatag cacagggcat ccctgtagat ctttcaccca gatccctcag atgttagcac 1861 agatgttaac attttgccct gtttgttccc cccagctcac tttccgaatg tgaatatggg 1921 tgtgtgtata tgtactgtat atgcattttt tgcctgaatc ttttgaaagt aaacacttca 1981 gtgtgttttt cctaaaaaca agggcaatat cgcacataat cactattcca ttttgaaaat 2041 cagcactgac acattcatga tctaatgctc agactcattc agctttccct gtctgttgac 2101 ggccttcgtg ccctaggacg ctcctgggcc atgagtgcat gagttcagcc ctgtcctgtc 2161 ccctcggcct cttttaacct gcagcagcag ctgggtctgt gccacgaccg tgccatttcc 2221 cagggtctag caggtgtgga tggagactat gctgactctg ggtgggcttg atgctgctca 2281 agatgagatc taggccatgc ggctcatcct cctcccagaa tactctccgc aggggccaca 2341 cgtgagcctg gcaccttgtc ctgcagagcc ctgcttccct ccccaagtca cacccctggg 2401 cacagtcccc taggactagc ggccttcacc ctcaggccgg ctgaccaccc cctacatccc 2461 agggcagctg agtccctgct ggggtggagc atgcctgacc ctgcctctat cagctgatgc 2521 agagttagac ctcagccaga tgaagacacc cagcagaccg gagtaggggg tcggatcggg 2581 agggagcttc agtagggcta ccaggcccag cttgacctgc atcccatggc agagcagcga 2641 acagtgacac agactttaga gctcctccac cttctcttgg aaattcagag gagtccagac 2701 cagccgcgtt tctcccgcag ccgtcagctg gggccctctc cctgcacagg agggccattc 2761 cctggtgtag ggtccccgct ggcctgcacc tctctctcac tgggagtgaa gcatggggca 2821 ttgtagatcg ttgggccctg gagcctattt tacagaggag cagactgaca ccagagggat 2881 cacaggcctt gcttgtgctt ctacaggact tgtgtgtggt tccacagggc aaggtctagc 2941 accctggtcc cagggtccct catcccatgc ttctccacag ttctgacaag tcatgttttg 3001 gggcggcact gtgcagggaa agcattcagt tctcttctga agttgcaacc ctaagacatg 3061 caggtgtgtg actcacttta gaaatattgc cttgaaaatc acacctggaa tggaagcacg 3121 tgggaagcaa tgtttattgg cctaaaacat caatgtatgt gagcatctca tctcctagtg 3181 agaaatgagg aaaaatacct ctgggttaaa tggcaggaat gagatgctct gtggactgaa 3241 tgccaggaac tggaagtttg ccgaaatttc atcatcacat gagaaccttc ctagaataga 3301 tccagtgtcc ctgccccctg ggtcataggt agcggaattc agttaatcct tggcattggc 3361 atagagaaac aagttactgg ggaggcctgg ggcatggcat ccctgccagc tggcaggagg 3421 aggtggcttg tgtgccttgc aggtgacaat gtgggcagct catgaaggta ggcttgaagc 3481 cccaggcaag cccagtgacc cggtcacagt gaagtgcctg tgtgtgtaag aaactgacag 3541 aacgtgctgt ccctgcctcc tgctctttca catgtgtaga tcgtagctgg ggtgaactac 3601 ttcttggacg tggagctggg ccgaaccacg tgtaccaaga cccagcccaa cttggacaac 3661 tgccccttcc atgaccagcc acatctgaaa agggtatgtg ccttatatgg gtccagggcc 3721 agtcatacac tgcagagggg tgtgtgtgtg tgtgtgtgtg tgtgatgcac atgttctgca 3781 gggtacgtgt gcatgtgcct gagtgtgtgt acacgtggag atgcatatgt gtttccaagt 3841 ataggtttgt gtggggaagt gcacgtgagt gtgtgcaagt gggtgtgtgg atgtgttggg 3901 gaagtgtggg ggtttatgca tggataggtg tgggtgtgtg agtatatgtg tgtgcacata 3961 tgtgtggggg tgtctgtgca catacattca catacatggg ggtttctgtg aacatacatg 4021 ctgtattatg aggaattacc tgccctgtgt gtgtgtgtgc atgtgggtag atagatgtat 4081 gagggagtat gtggattcat gcatagatcc gtatgggtga aggttagggt gagttcatgt 4141 agatgcctat gtgtgtgcat gtagacgggg tggtgtggag aggagtgatg aatttgattt 4201 gctaagaggg ctttagcttg ggattggggt actgggagct ccaccctatg tgctttggag 4261 tgttgcctac tggactgcag gaagcagctg cagggctggg tgctgggcag ggagaaaggg 4321 ctctgtctaa tcccagcctt aggcacctgc ccacagccac ggccatgctg agcagattag 4381 agggtagtag aggcctgtta gcagccaaac cctcagacct gccccagctc acccaacacc 4441 agcttctcca aggacccagg atttcttgtg acgtctctgc tcaggggaga gccacactct 4501 ccttgtcatc tcctcaccac cccatgtgct atgacttgga atttccagtt ccctgggttc 4561 ttccctctcg cccttcatag tgctggcctg agggctggag gtggaaggag ctgggggcag 4621 tgagctgcct ccccctgccc tgtaccctta gggctcccga ggccttgcac aggctgctcc 4681 tcacagggct gtgctggggc aggaatcctg caggctgggg tgggggccca gtgccaccag 4741 gtagagttgg agccctggga gagggatgga gcagtcactg cccagtccag cggtgctctg 4801 ggatcagcgg gggtgggtgg aggggtagat aagggcccag tgtttcacct ccatccttct 4861 tcactcccac tctgatgtcc cgtgcctggg catcttctgc tttgaactgt aacccacact 4921 gattgtcccc tctgtttcct ttcacagaaa gcattctgct ctttccagat ctacgctgtg 4981 ccttggcagg gcacaatgac cttgtcgaaa tccacctgtc aggacgccta ggggtctgta 5041 ccgggctggc ctgtgcctat cacctcttat gcacacctcc caccccctgt attcccaccc 5101 ctggactggt ggcccctgcc ttggggaagg tctccccatg tgcctgcacc aggagacaga 5161 cagagaaggc agcaggcggc ctttgttgct cagcaagggg ctctgccctc cctccttcct 5221 tcttgcttct catagccccg gtgtgcggtg catacacccc cacctcctgc aataaaatag 5281 tagcatcggc tccctctgag ttcttggctg tctggggatg tgcacacagg cagggtttcc 5341 gcagttcctt tatgaagcct ccttgtcctg ctggtgtgaa gatgagagga gtacctggga 5401 gctgacgcgg ccacagcaag gccatcaggc aagctgctgc tataggagtc ctgagtctca 5461 gagcagggag agcagccagg ggctgggaaa caaggcgttg agccacagca gcccctggtg 5521 agggggtcag ggagaggagg ggcccaagct gctgccccca gaagctgggc tggtgatttg 5581 gtctgagctg ctggtcagac caggaggagg gagctggctg tgtccataga caggggccag 5641 gcctcggtgg agctcgccag gtcatagatt ccatctgtgc ttgcagagtt gagcagaccc 5701 cagggactga gctgctctca tcaaatcccc tagacactaa atagtgatca atgcgtgctt 5761 ctttccaaga gacttaggcc cctacgtgga aacaaagtcc aaaaagcctg tctgtgtaac 5821 tgagcaggag aaatgccagc cagaccagag accagcaaga tcacagagaa agtggcacct 5881 gctgtcatcc atcctgggag gctgtgtcct cccagagttt tacaggctca tagccaccag 5941 ccctttctct ggacttggat ttaaaacaag ttgttagtcc agcttcatgg tagggatgaa 6001 gttaaagcac aaatgagacc gacaatgcag tggactcttc tttttccaag gaggattaag 6061 agagaacatt cccttcatgt cagcattatc ctatagaata gtggatcttt gtgccacaag 6121 caggaggcta cagtcctaag acacagccca ccctgcacag tccttccctt tgccatttta 6181 ggacaggggt gcagccctta cagccagtgc tgctggggca ggcctcccag gtaccttcca 6241 acctcggagc tgcactgacc ccctcttttg gctgctgcca tgaacactga aggtgaaatg 6301 atgaaggaaa atccacccca gtagcgccaa ggccagcacc ccacatgctg tccctgcaaa 6361 gtcagagcag gggacacggc agggagagtg gggagcgtct gcttcctttt cctctccacc 6421 ctgacttgct ttaacagggt ctttggggtg agggaagtgt agcaccccct aggatgccat 6481 gagctgagga gatttgagtc tgggcctcac cctgctgggg gtgggtggtc ttagtcactc 6541 agttttctgt ggggggttgg gggatagaag tggtggttgt ggtcagtggt aaagggtccc 6601 tgcagggagg tgctcctggt tttctacctc ggtgaaggat ctttgacaca ggcaacctcc 6661 atccaggcac ccagtggaaa cggacagctg accatatagc ccagtgcctt ttctgacaca 6721 cttcttcctt ggggaagttg aggttggggg cgggctgtgc acagggctcc ccagcctccc 6781 tgtgtgtctg cttccttccc tgccctccgc ccggtggccc catggcccac agcccacagg 6841 gaagcaagtt ggtgccaccc ctgcctcccc tccgcagccg gcgggcctgt aaatgcctcc 6901 cttgggcccc catgaggcca gtgagccaga agcccctctg acccagaggt cactgtgacc 6961 agcacatcct ggagaggagg cctcgccctt gcacctttca tctgcaagag ttacttttac 7021 atttatttta aatgttgatt taagtatata cttcatctac agttatccat ataaatagat 7081 tcattacagg gcctggctct gaataaacac agtaagttgg agaggctttt tcattgatct 7141 ggttctacac tggtggcttt ataacatagt gctttgacac ctcttgcatt gtgttgctgg 7201 tgaccattgg ggtgggatca ggaagggccc agtagcttct gagctcccta gcattcttgt 7261 cctgaaggaa gccagccttt gcagaaggat cc //