LOCUS HSCST4 4285 bp DNA PRI 13-NOV-1991 DEFINITION H.sapiens CST4 gene for Cystatin D. ACCESSION X59964 NID g30263 KEYWORDS CST4 gene; cystatin; cystatin D; cystatin superfamily; cysteine-proteinase inhibitor; extracellular protein; secreted protein. SOURCE human. ORGANISM Homo sapiens Eukaryotae; mitochondrial eukaryotes; Metazoa; Chordata; Vertebrata; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 4285) AUTHORS Otin,C.L. TITLE Direct Submission JOURNAL Submitted (29-MAY-1991) C.L. Otin, Departamento de Biologia Functional, Unversidad de Oviedo, Facultad de Medicina, C/Julian Claveria s/n, 33006 Oviedo, SPAIN REFERENCE 2 (bases 1 to 4285) AUTHORS Freije,J.P., Abrahamson,M., Olafsson,I., Velasco,G., Grubb,A. and Lopez-Otin,C. TITLE Structure and expression of the gene encoding cystatin D, a novel human cysteine proteinase inhibitor JOURNAL J. Biol. Chem. 266 (30), 20538-20543 (1991) MEDLINE 92041895 FEATURES Location/Qualifiers source 1..4285 /organism="Homo sapiens" /db_xref="taxon:9606" /germline /cell_type="blood leukocyte" /clone_lib="Charon 4A" /clone="ChC21" GC_signal 344..349 TATA_signal 389..393 /note="tata box-like sequence" exon <489..719 /gene="CST4" /number=1 mRNA join(<489..719,2546..2659,3894..>3977) /gene="CST4" gene 489..3977 /gene="CST4" CDS join(489..719,2546..2659,3894..3977) /gene="CST4" /codon_start=1 /product="cystatin D" /db_xref="PID:g30264" /db_xref="SWISS-PROT:P28325" /translation="MMWPMHTPLLLLTALMVAVAGSASAQSRTLAGGIHATDLNDKSV QCALDFAISEYNKVINKDEYYSRPLQVMAAYQQIVGGVNYYFNVKFGRTTCTKSQPNL DNCPFNDQPKLKEEEFCSFQINEVPWEDKISILNYKCRKV" intron 720..2545 /gene="CST4" /number=1 exon 2546..2659 /gene="CST4" /number=2 intron 2660..3893 /gene="CST4" /number=2 exon 3894..>3977 /gene="CST4" /number=3 polyA_signal 4212..4218 BASE COUNT 895 a 1115 c 1236 g 1039 t ORIGIN 1 gaattcccag accatgacca cgtgctcctg gatgcccctg acatctgaag actttagaag 61 gccaagccct gtatttctcc ctttcctgtg gacataggtg gtcaccaggt ttcacagccc 121 agggagcggt gtcacctctc tggaatccag agtgagccaa gctttagagc actgaggaag 181 aggggcaggg ctgtggggag gttgcggtca ggacaggagt ggggaggagg atgaggagga 241 ggcatgggag gagcgaaggg aacttaggga gggagggagg tggttggggg tggaaaggga 301 gatacagaca gaagaggagg ggtagaaaga ggaggaggag ccagggcggg gccagggagc 361 aggtggggtt gggggacacc caagtaggat aaatgcacag ctagcttctg gcctgggctt 421 cctgcctcag ccttctgctg ctttgctctc tgggagatcc agctccttgc tctgtgtccc 481 agtagaacat gatgtggccc atgcacaccc cactgctgct gctgactgcc ttgatggtgg 541 ccgtggccgg gagtgcctcg gcccaatcta ggaccttggc aggtggcatc catgccacag 601 acctcaatga caagagtgtg cagtgtgccc tggactttgc catcagcgag tacaacaagg 661 tcattaataa ggatgagtac tacagccgcc ctctgcaggt gatggctgcc taccagcagg 721 tgcgtgctac caccaccctg ggggtcctga gtcccagctg ggttttttgc ctcacccccc 781 agagcactcc cagcaaatca acattatcta aaccgcagac tcattcagct ttctctgact 841 gtctgctgat ggtcttcatg ccctaggaca ctccttggcc gtgagtgcat gagttcagcc 901 ctgtcctgtc ccctcggcct cttttaacct gcagcagcca ctgtgtctgt accatgactg 961 tggcatttcc cagggtccag caggtgtgga tggagactgt gctgactctg ggtgggcttg 1021 atgctgctca ggatgagatc caggccacga ggttcatctt cctccctgag tcctctccac 1081 aggggccaca cgggaacctg actccttgtc ctggatagcc ccgcttccct cccaagtcac 1141 gcccctggca cagcccgtta tggctagtgg ccttcactct caggctggct gaccaccccc 1201 tacagcccag gacagctgag ttcctgctgg ggtagagcat gcctgaccct gcctctgcca 1261 gctaacgcag agttagacct cagcaaaatg aggacagcaa tcacccagca gagtgaagga 1321 ggtggttggg tccagaggga ggaagcttca gcagggctac cgagcccagc ttgacctacg 1381 tcccatggca gagcagcagt gacacagcga ccacagggct atatggcctg ccagccttta 1441 gagctcctcc accttctctt ggaaagtcag aggagtccag accagccctg tttctcctcc 1501 tgcagccctc tccctgcaca ggaggggcat tccctggtgc tgtggtccct gctggcctgc 1561 actccctctt aagtgtgtca ctcactggga gtgaagcaca gaatgatgta gatcgttggg 1621 ccctggagcc tattttacag agcagcagac tgacaccgga gggatcacag gacttccatg 1681 tggttctaca ggacttgtgt gtggttccac agggcaaggt ctagcaccct ggtcccaggg 1741 tccctcatcc catgcttctc cacagttctg acaagtcatg ttttggggcg gcactgtgca 1801 gggaaagcat tcagttctct tctgaagttg caaccctaag acatgcaggt gtgtgactca 1861 ctttagaaat attgccttga aaatcacacc tggaatggag gcatgcagga ggcaatgttt 1921 attggcctaa aacatcaatg tatgtgagca tctcatctcc tactgagaaa tgaggaaaaa 1981 tacctctggg ttaaatggca ggaatgagat gctctgtgga ctgaatgcca ggagctggaa 2041 gttagctgaa atttcatcat caggtggcag ccttcctagg atgggaccag tgtccctgcc 2101 ccctgagcac aggtagcaga attcagttaa tcctttgctg tgggaaagag cattcacttg 2161 gtgcttagac cctgccctgc aagcctggtg ccaggactgt ttctttgtcc caccctggct 2221 ggttccccag agctgtgcct tctgttcctg aatccagtga agggggtttt aggccctggc 2281 ttccatctgc cctgcccctg cttctctttc tactgggctg catgagacag cttgcttgag 2341 atacccagag aaaacaagtt actaggaagg actgggacac actaccactg ccagccagca 2401 ggagaaggtg gcttgtgtgc cttttgggtg acagtgtggg catgaagccc caggcaagcc 2461 cagtgactca gtcacagtga agtgcctgcg tgtgcatgaa actgacagca tgctgcccct 2521 gcttcctgct cttccacgcg tgtagatcgt gggtggggtg aactactact tcaatgtgaa 2581 gttcggtcga accacatgca ccaagtccca gcccaacttg gacaactgtc ccttcaatga 2641 ccagccaaaa ctgaaagagg tatgtgcctg atgtgggtca ggggcatcaa gtaccgcaga 2701 gcagtgtgtg catgtgtgtg tgtgtatgtg tgtgtgcacg catctgtact cctgcacatg 2761 ctttggaggg catgtgtgca tgtgtgcaga tatttgtggg gccacgtatg caaggatgta 2821 ttcatgtgca tgggaggatg catgtgtgtt tggcacacat gtgcagatgt gtattgtgaa 2881 gtcaatgaat gtgtttgtgc atatggagtt ttgtgtatgc atgaatgaat gtgtgggatg 2941 gtgtacacat gtggctatgc atgtagaaag atgcatatgt gtgcatacat gaggaagatg 3001 cacaggagtg tgtgtgtgca tgtgtgtgga tgtgtgaagg agtatgtggg ttcatgcata 3061 tattcgtttg ggtgagggtt gctgtgagtt aatatagatg cctatgtgtg tgcagatgga 3121 gtgggtgtgg ataggggtga tgaatttgtt ttgctaggaa gactttagct tggtaatggt 3181 tactgggagg tcaactctgc ctgctttggg gtgttgtctg ttggactgga ggaagaagct 3241 gctgggctgg gttctggtca gaaagaaggg gctctgtcta accccagcct caggcacctg 3301 cctgcagcca cagccactct gagcacatta gaaggaatta aatgcctgtt agctgagaag 3361 ccctggacct gccccagctc acccaacatc agcctctcca agaacccagg atttctttcg 3421 aggtctctgc tcaaggcaga gccacactct ccttgtcatc tcctcaccac ctcgggcact 3481 ttgagttgca atttccagtt ccctgggttc ttccctctgg cccctcttag tgctggcctg 3541 ggtgctggag gtggaaggag ctggaggcag tgagctgcct cccctgtcct gcacccctga 3601 ggctcccaag gccttgcaca ggctgctcct catagggctg cgctgggaca ggaatcctgc 3661 aggctggggt gaaggcccaa tgtcacctgg tgacttggag ccttgggagg ggcaatggaa 3721 cagtcactgc ccagttgggc tcagtgccct ggaactcggc aggggtaggt tggggtcagg 3781 gggcagtgtc tcatctccaa ccattttcac ccccattctg atgtcccatt cctgggcatc 3841 tttggcttta actgtaaccc acagtcattt tctccatctc tttcttttca caggaagagt 3901 tctgctcttt ccagatcaat gaagttccct gggaggataa aatttccatt ctgaactaca 3961 agtgccggaa agtctagggg tctgtgcaag gcctgtcaca ctgaccacct cctactccca 4021 ccccctgtag tgctcccacc cctggactgg tggcccccac cctgggggag gtctcctcat 4081 gcgcctgcac caggagacag acacagaagg tggcaggagg cctttgttgc tcagcaggag 4141 gctctgccct tgctccttcc ttcttgcttc tcatagcccc agtgtgcagt gcacactctc 4201 ccacctcctg caattaaaca gtagcattgc ctccctctga gttcttggct gtttggggat 4261 gtacacacag gcagggtttc tgcag //