LOCUS HSDAO 9903 bp DNA PRI 19-JUL-1994 DEFINITION H.sapiens diamine oxidase gene. ACCESSION X78212 NID g463242 KEYWORDS amiloride binding protein; diamine oxidase; histaminase. SOURCE human. ORGANISM Homo sapiens Eukaryotae; mitochondrial eukaryotes; Metazoa; Chordata; Vertebrata; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 9903) AUTHORS Chassande,O., Renard,S., Barbry,P. and Lazdunski,M. TITLE The human gene for diamine oxidase, an amiloride binding protein. Molecular cloning, sequencing, and characterization of the promoter JOURNAL J. Biol. Chem. 269 (20), 14484-14489 (1994) MEDLINE 94237856 REFERENCE 2 (bases 1 to 9903) AUTHORS Barbry,P. TITLE Direct Submission JOURNAL Submitted (16-MAR-1994) P. Barbry, IPMC/CNRS, 660 route des Lucioles, ZA de Sophia Antipolis, 06560 Valbonne, FRANCE FEATURES Location/Qualifiers source 1..9903 /organism="Homo sapiens" /db_xref="taxon:9606" /dev_stage="adult" /chromosome="7" /map="q35" exon 901..955 /number=1 mRNA join(901..955,4840..6425,7145..7430,8880..9012,9322..9668) /product="amiloride binding protein" intron 956..4839 /number=1 exon 4840..6425 /number=2 CDS join(4856..6425,7145..7430,8880..9012,9322..9588) /codon_start=1 /product="amiloride binding protein" /db_xref="PID:g463243" /db_xref="SWISS-PROT:P19801" /translation="MPALGWAVAAILMLQTAMAEPSPGTLPRKAGVFSDLSNQELKAV HSFLWSKKELRLQPSSTTTMAKNTVFLIEMLLPKKYHVLRFLDKGERHPVREARAVIF FGDQEHPNVTEFAVGPLPGPCYMRALSPRPGYQSSWASRPISTAEYALLYHTLQEATK PLHQFFLNTTGFSFQDCHDRCLAFTDVAPRGVASGQRRSWLIIQRYVEGYFLHPTGLE LLVDHGSTDAGHWAVEQVWYNGKFYGSPEELARKYADGEVDVVVLEDPLPGGKGHDST EEPPLFSSHKPRGDFPSPIHVSGPRLVQPHGPRFRLEGNAVLYGGWSFAFRLRSSSGL QVLNVHFGGERIAYEVSVQEAVALYGGHTPAGMQTKYLDVGWGLGSVTHELAPGIDCP ETATFLDTFHYYDADDPVHYPRALCLFEMPTGVPLRRHFNSNFKGGFNFYAGLKGQVL VLRTTSTVYNYDYIWDFIFYPNGVMEAKMHATGYVHATFYTPEGLRHGTRLHTHLIGN IHTHLVHYRVDLDVAGTKNSFQTLQMKLENITNPWSPRHRVVQPTLEQTQYSWERQAA FRFKRKLPKYLLFTSPQENPWGHKRSYRLQIHSMADQVLPPGWQEEQAITWARYPLAV TKYRESELCSSSIYHQNDPWHPPVVFEQFLHNNENIENEDLVAWVTVGFLHIPHSEDI PNTATPGNSVGFLLRPFNFFPEDPSLASRDTVIVWPRDNGPNYVQRWIPEDRDCSMPP PFSYNGTYRPV" intron 6426..7144 /number=2 exon 7145..7430 /number=3 intron 7431..8879 /number=3 exon 8880..9012 /number=4 intron 9013..9321 /number=4 exon 9322..9668 /number=5 BASE COUNT 2526 a 2646 c 2664 g 2067 t ORIGIN 1 aagcttcaag ttgactaagt gtgttcacct tccttcatct agctgccagt gcacactgaa 61 atggcttgca ttgcgggcag caggaaggat gatgatgaga aatacaaaac ccctataacc 121 acaaagcggt gtgcaatccc tgagcaacca aaccttggta atgggggatg atgacccctt 181 ggcactcctg agccacgaac ttttcctgac tctattcttt cctttccaac taggagttac 241 cccggtcacc acgttcgccc ttctcaacct gactaagtgg gcgttagcac tgtccgccca 301 ctgcatgggc actacctgcc ccagtgtcct ctcccctctc cgctctgtgc catagcctta 361 gctaccctgg ccagctttct cccagccaag tccttcctcc tttctgaatc tggtcagggt 421 ctcaaagatc gttaaaaagc cgccaaagtt tgcaactcgt cttgagtggc tgctcctccc 481 aaacggttct gcctctggtg tcttgttcta ggagcggttg aattctctgt tttgctgtgg 541 gtgccagcct ctatcagccc ctgccctggt ccatctgtca gcttcaggta agactaccgg 601 ctaggaaatg gccccttgtc cttatctctg cctctaaaat atgccaccta aattaacaga 661 tcgtggcatt gcatggctcg tcacagagaa gccaaggcaa attcttgtgg aaggcggcac 721 ttgtctggaa acagactcag gacaagtgtg ctgcacagcc agcttcctca aacccactct 781 cgccactgta gctgcccaca gaggcacctc ccaagccata ggcccctcct aggccagctc 841 aggcctcacc ttgtccctcc ctgcagggcg gggtctgatt gacttcaaga aggagtcaga 901 gatcagctta agggcaaagg ctggaagcag agcgaactgg gagcagagca cacaggtgcg 961 ttctgatggg tattcgggag agtcaagaag gggctgacct ggaggacaga aaagcagtgg 1021 aaggagggca cagagtgagg ggcagaagaa acaggacaca gagggaggag ggccaggaag 1081 tgagggcggg agcccagcac atcacagaag gtgcccgggt gcttggtggc aggcaacagc 1141 cggccagggt ggagtgggga aagctcagag aggagggtga gcagggagag ggcttgcttc 1201 ctgttcctgc ctggaggtct caccagccac cacccccact gccactgcac atggggacag 1261 aggtttgtcc tggggaaagc aaaggtctct tccacatctt tctccttcct ggaaaagcaa 1321 aaagaaacgt gggtataaga ggttgtaaaa aaggagaccc agccgcgaaa ggacatggag 1381 gtaccctaaa tgcacactgc caagcaaaag aagccaatct gaaaaggctg cagactgtaa 1441 gattccaaat acaggacgtt ctggaaaagg caaaactatg gagacaataa aaagagcagt 1501 gattgctagg gtttcggagg aagaggtgga gcacagaaga ttttggcgga ggtggaacta 1561 ttctgtgtga tattctaatg gtggatccat gtcattgtcc gtttgtccaa cccatagaat 1621 atgcagcagc aagagtgagt cctgatgtaa actgtgggct ctgggtgaga gtgatgtgca 1681 ggttcatcag ccacaaatgt atggctctgg tgtggatatt gatagtgggg aggctgcgtg 1741 tgtaggggct gtgagtatac agaaactctc agtacctttc gctcaatttt gctatgaacc 1801 taaaattcct ctttaaaaga ctcctattta aaagacttta atagacttta taaagtttgt 1861 taaaagactt ttaatagact ttttaaagac ttttaacaga ctttataaag tctattaaga 1921 aatctattaa agtctatttt taaaagtcta ttaaaaaaaa agtctactat aatcccagca 1981 ctttgggagg ccaacgcagg aggatcactt gagcccagga gttcaagacc agcctgggca 2041 acatagtgag atcctgacta tatatatata tatatattta tttatttatt tatttattta 2101 tttaagtcta ataagaagtc tatttggggc caggcctggt ggctcatgcc tgtaatccca 2161 gcactttggg aggctgaggc aggtggacca cttgaggtca ggaattcaag accagcctga 2221 ccaacacggt gaaacaccat ctctactaaa aacaaaaaat tagccgggca tggtggtgca 2281 cacctgtaat cccaactatt ccagaggctg aggcaggaga attgcttgaa cctgggaggc 2341 agaggtagca gtgagccaag atcgcatcac tgcactccag cctgggctac agagcaagac 2401 tgtctcagga aaaagaaaaa atagtctatt taaagaagaa aaaaaagagg cctggccaat 2461 atttaatagg agaacacaag aactcacctc atatccttcc tgctggctct gggttccgcc 2521 tgcagcccct gcctcacctg ctccctccag gtaagcaggg tctccgagag cccaagatca 2581 tgtgggttcc agggtcttct gccagcacca gagggcaaga caaggcaact agagggacat 2641 ccccatgaga ggccatgacc atggagcaaa acgagggcaa ggggagagcc ctcggggaga 2701 ggggcatggg aaagggagag aaggacatct cagatcagcc tttaccgtgg cctccagggc 2761 tagagagccc tcgggtgatg gaacaggccc agccaacacc tttcatttgt ctatgaatca 2821 agaactgccc atcgtgtaca aattaaatac aaagtgctaa ggggactagt ggagaagtat 2881 gttagttggg gccaaaaaca gcattcctcg gcagtgcggg gtttcagctg acctcaaaag 2941 gtggcaaagg atgtgacact ggcccagagt cgggtgggaa gggacaatgt gcagctgagc 3001 ttctctggag gaaaaaagcc acgggaaaac agggcctcta gttaacacat gggttgtgtt 3061 cccaacgctt gtgcttcgga aatgtgatgt gtaaatgcat tttccaaaaa caaaagcaag 3121 aaatgaaaag cgctcatgat ggtcaggttt cctcagtggg tcactccacg atacacccaa 3181 agtggagctg ctgcacctca gttacacctc acaccctgtg ccgccgactt tccaggtgaa 3241 atcctcgggg cctcccttgc aggcagcctg ggccccctgg gaagaggctg ggccaggcag 3301 aggtctgaga caggagtgga ttaaccctct ctgctacctg tctgtctgca caggagaacg 3361 agttttctcc aggtttaccc ccagggcttc tgatttaggg agcaaaaggc aactacctat 3421 gaaaatatga aaacaaggat ctctcagagt ccaacccact catgcatcca ccttataaat 3481 caagtgtctg tgcctcaggc actgcttgca ggaagtgaaa agcacagctg agacagggag 3541 gaatcctgaa gcggggctcc cagctcaacc cagagccttg aggaaggggg tgcaaggtgg 3601 caaaggcagt gcttctgtag ggaaatttcg cggtggcggc agccttccag ggaggcccac 3661 atcacctagg aggacaagtt agggtctgga gaaactaagg ctgggagaca gctccagcca 3721 gcatctgtag caacagcgca acaggcaaga gtaacagtct cccagagact ccgcacacag 3781 cacatgggaa gacagagctg tggccaccac gtctcccagc cctgcaggag gctcacagct 3841 acaagcacag gattttacag ctgcttgggg aatggggtta tgaggtgaag accctgaccc 3901 accctccctg agaaaggaaa aggcatcttc ctaagatgaa accctccctg aggtcccctc 3961 ctagtagcct tgggtggaca agagaggtga atggggcaca aagaaggcta ggcaggactg 4021 ggcacctcta cctcaccccc aaagccatca gtctgcagcc tagtcacacc tgaatcactc 4081 tacattgcgt aaaactttaa atgggctggt gtcgatagcc tgtatttaac aagaagagca 4141 gctaacattt ctcatgtatt tcccatatgg cagacattgt tacacacact ttatatttac 4201 tgtttaattg atttctctcc acaaccctag gagctaagca ctgttgtcat tattttcatt 4261 ttaaaactaa gaacatgaag gcccagagag tttaagcagc gtgcccaagg ccacacagca 4321 agtcctagtg gcatgagtca ctgggacttg actcagatag tttgactcta gagcctacct 4381 ttgaatttct acactaaatt tcaaaatctg tctacctaaa aggtatttcg ttgtgtcaga 4441 aatgtagttt tgctgttaat acaggtgtct tcttctccag gacacaagaa gcacctgggg 4501 gcatgtgcag gggcccagcc tggcctctgt gactcacgca cccctggctg agataataca 4561 caaaaacaag ggtgttcccc tgagtaagga aggctgcagg actgaaggac atttacagag 4621 gagtgaggag agggcagaaa taaatggatg gatgcacagg cagcggcccg acggcgctgg 4681 ggactatgca tgggccccag ctgccccagg acagcctcca gcttggggca gggcaagggg 4741 aggaagctca gtccatggga aaattccatg gccctaacct gagggaagcc catctctgcc 4801 cataagacaa ctaagttcat ctcctctatt gcattccaga gccgtggagc gagagatgcc 4861 ggccctgggc tgggccgtgg ctgccatcct gatgctgcag acggccatgg cggagccctc 4921 cccggggact ctgcccagga aggcaggggt gttttcagac ctaagcaacc aagagctgaa 4981 ggcagtgcac agcttcctct ggtccaagaa ggagctgagg ctgcagccct ccagtaccac 5041 caccatggcc aagaacaccg tgtttctcat cgagatgctg ctgcccaaga agtaccatgt 5101 gctgaggttt ctggataaag gtgaaaggca tcctgtgcgg gaagcccgtg ccgtcatctt 5161 ctttggtgac caggagcatc ccaatgtcac cgagtttgct gtggggcccc tgccagggcc 5221 ctgctacatg cgagcactgt cccccaggcc tgggtaccag tcctcctggg catcgaggcc 5281 catctccaca gcagagtatg ccctcctcta ccacaccctg caggaagcca ccaagcccct 5341 gcatcagttc ttcctcaata ccacaggctt ctcattccaa gactgccatg acagatgcct 5401 ggccttcacc gatgtggccc cccggggtgt ggcttctggc cagcgccgca gttggcttat 5461 catacagcgc tatgtagaag gctactttct gcaccccact gggctggagc tcctcgtgga 5521 tcatgggagc acagatgctg ggcactgggc cgtggagcag gtgtggtaca acgggaagtt 5581 ctatgggagc ccagaggaac tggctcggaa gtatgcagat ggagaggtgg acgtggtggt 5641 cctggaggac ccgctgcctg ggggcaaggg gcatgacagc acagaggagc cgcccctctt 5701 ctcctcccac aagccccgcg gggacttccc cagccccatc catgtgagcg gcccccgctt 5761 ggtccagccc cacggccctc gcttcaggct ggagggcaac gctgtgctct acggcggctg 5821 gagctttgcc ttccggctgc gctcctcctc cgggctgcag gtcctgaacg tgcacttcgg 5881 cggagagcgc attgcctatg aggtcagcgt gcaagaggca gtggcgctgt atggaggaca 5941 cacacctgca ggcatgcaga ccaagtacct cgatgtcggc tggggcctgg gcagcgtcac 6001 tcatgagtta gcccccggca tcgactgccc ggagaccgcc accttcctgg acactttcca 6061 ctactatgat gccgatgacc cggtccatta tccccgagcc ctctgcctct ttgaaatgcc 6121 cacaggggtg ccccttcggc ggcactttaa ttccaacttt aaaggtggct tcaacttcta 6181 tgcggggctg aagggccagg tgctggtgct gcggacaact tcaactgtct acaattatga 6241 ttacatttgg gactttatct tctaccccaa cggggtgatg gaggccaaga tgcatgccac 6301 tggctacgtc cacgccacct tctacacccc cgaggggctg cgccacggca ctcgcctgca 6361 cacccacctg attggcaaca tacacactca cttggtgcac taccgcgtag acctggatgt 6421 ggcaggtagg actcaaagcg agactctccc gttcaaacat ctgcatccag ccaataactt 6481 aaactcccag gagacggcac tataactccc tggtggtgga aagttaggag catttgccaa 6541 gcctgcttct gtaaaaccta aagctagaaa tttgtgtgtc cctgaaaaat ggtgaaagcg 6601 aacagtgccg agggttgccc tggatgcaac agtgtggacc ctgtcctgac cctggggctg 6661 tgcatggggc aagggagggg acggtgccta tgagggtaag aaatgtcact gtctagcgct 6721 ttgagatgga gtgtagtatt gtctgggaat attcagggtg tctcctggat gatatcacca 6781 taaaagaatg gcatgggtag aataactaat gctgccagac ccaacaaggc caccaggacc 6841 acacgggcgg ctcctacccc tcagcccagt cacctctctg gacagagcct cccatgcctg 6901 gagaaaaatg gtgccctgct ctaggattgc agccacagca gatgggcatg agcacagctc 6961 ttgagaggaa cttcccagag tggtaatgga atcaccacag ccgcccaggg catcccccaa 7021 catcccggtt attcaagaca gttggctgtt ggatgtggtg gaggatggag atcctggggt 7081 agaatgagga ggtttcagtt ctgacagctt gattctcgtt ctccttctcc ctgcatacct 7141 ccaggcacca agaacagctt ccagacactg cagatgaagc tagaaaacat caccaacccc 7201 tggagcccaa gacaccgcgt ggtccagcca actctggagc agacgcagta ctcctgggag 7261 cgccaggcgg ccttccgctt caaaaggaag ctgcccaagt acctgctctt taccagcccc 7321 caggagaacc cctggggcca caagcgcagc taccgcctgc agatccactc catggccgac 7381 caggtgctgc ccccaggctg gcaggaggag caggccatca cctgggcaag gtgaggaaga 7441 cccagggggc ctgggggagg gtcagtggct tccctcagtg tgtgtgtctg tgtctgtctg 7501 tgtttgtgtc tatggggttc ctagtctatg tggatataca catatacgta tgtgtatatc 7561 tgtgtgtaca attgaccctg aacaatatgg ggggtagggg tgccaacccc ccaaagcagt 7621 aaagaagcca agtgtaacta tgactccccc acaacgtaac tacgaatagc ctactgttaa 7681 ccggaagcct taccactaac agaaacattc cgtgaacaca tattttgtag gttctgtgtg 7741 tcagatactg tgttcttaca ataaagtaag ctagagaaaa gaaaatgtta ttaataaaat 7801 cctggccggg cacggtggct cacgcctgta atcccagcac tttgggaagc tgaggcagac 7861 agatcacgag gtcaggagat caagaccatc ctggctaaca cggtgaaacc tcatctctac 7921 taaaaacacc aaaaaattag ctgggcatgg tggcaggcac ctgtagtccc agctacttgg 7981 gaggctgagg caggagaatg gcgtgaaccc gggaggcgga gcttgcagtg agccgagatc 8041 acaccactgc actccagtct gggcaacaga gcaagactag ttctcaaaaa aaaaaagaaa 8101 aaatcctaag gaaaagaaaa tatatctaca atccattaag tgggagtggc tcatcccaaa 8161 ggtctttatc ctcgtctcct tcactttaag tgggctgagg aagaggagga ggaggggctg 8221 gtcttgctgt ctcacggtgg cagaggcgga agaaactcca aatgaaagtg gacttgttgc 8281 tgggcgcagg agctcacgcc tgtaatccca gcactttggg aggccaaggt gggcagatca 8341 cctgaggtca ggagttcgag accagcctgg ccaacacagc gaaaccctgt ctctactaaa 8401 gatacaaaag ttagccgggt gtggccgtgg gcgcctgtaa tcccagctac tcgggaggct 8461 gaggcaggag aatcacttga acctgggagg cagaggttgc agtgagccaa gatcgcatca 8521 ctgcactcca gcctgggtga cagagcaaaa ctccatcaaa aaaaaagaaa agaaaagaaa 8581 gaaggaagga aagagagaga aagaggaccc atgcagctca cacctgtgtt gtgcaagggt 8641 tgcctgctgt tctgggcctg tgtctctgtg catttgggga agggggcggg gaggactcct 8701 gtgggtcacc tgaacccggt taacagcagc ccgtcctgct gactcccagg acagatgatc 8761 tgtcatcttg gggaaggcaa tcatcttcct ctattctgac cctgaggctg ttccctgggc 8821 aggactgagg gggcccagcc cagggccctg agccaagctg cttcgcctgt gcctggcagg 8881 taccccctgg cagtgaccaa gtaccgggag tcggagctgt gcagcagcag catctaccac 8941 cagaacgacc cctggcaccc gcccgtggtc tttgagcagt ttcttcacaa caacgagaac 9001 attgaaaatg aggtactgcc ctgtccccag ccctgcccgg tgctggccct gcctccttcc 9061 agctcagccc aggaccatcc tcatcaccat cagggagtcc caaccaccct ttgcccagat 9121 ctgtccccag tcgcaggagc tgtgccttgc tgtgtggacg gcaagttcag aggtcacaac 9181 agagctgctc atctctttaa aaaggggctg gagaggaatt cagcaagttt ccaggcagaa 9241 ctgaaaatga ccaaaggcta gagtggcctc cagtggtcag tactcagccc tgcccactga 9301 agcccaccct gtctcctgca ggacctggtg gcctgggtga cggtgggctt cctgcacatc 9361 ccccactcag aggacattcc caacacagcc acacctggga actccgtggg cttcctgctc 9421 cggccattca acttcttccc agaggacccc tccctggcat ccagagacac tgtgatcgtg 9481 tggcctcggg acaacggccc caactacgtc cagcgctgga tccctgagga cagggactgc 9541 tcgatgcctc ccccttttag ctacaatggg acctatagac ctgtgtgacc agcccccagt 9601 tcctccccca gttcctccca ggaagcccag gagcctcact ggggcagaca ataaactctc 9661 agagcctcgc tctgtgtgct gcttcttgcg gggagcacag ggccatgtgt gtaggaaaca 9721 cacgaacaga cgtgcacaca cacacagacg tgcacacaca cacagacatg cacacacaca 9781 cagacgtgca cacacacaga cgtgcatgca ctcacatgga catgcacaca catggcatgt 9841 actttattca cactggtcta ctgcagtcca gaaaagccac cattactaac aaaaaggaag 9901 ctt //