LOCUS HSENO2 10905 bp DNA PRI 25-JUN-1997 DEFINITION Human ENO2 gene for neuron specific (gamma) enolase. ACCESSION X51956 NID g31164 KEYWORDS enolase; neuron-specific enolase. SOURCE human. ORGANISM Homo sapiens Eukaryotae; mitochondrial eukaryotes; Metazoa; Chordata; Vertebrata; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 10905) AUTHORS Feo,S. TITLE Direct Submission JOURNAL Submitted (21-FEB-1990) Feo S., Istituto de Biologia dello sviluppo, del consiglio nazionale delle ricerche, via archirafi 20, 90123 Palermo, Italy REFERENCE 2 (bases 1 to 10905) AUTHORS Oliva,D., Cali,L., Feo,S. and Giallongo,A. TITLE Complete structure of the human gene encoding neuron-specific enolase JOURNAL Genomics 10 (1), 157-165 (1991) MEDLINE 91257823 COMMENT For overlapping sequences see and . FEATURES Location/Qualifiers source 1..10905 /organism="Homo sapiens" /db_xref="taxon:9606" /tissue_type="hematopoietic" /cell_type="PBL" /clone_lib="EMBL3" /clone="lambda G3" /chromosome="12" /map="12p" repeat_unit 205..508 /note="ALU-like element" mRNA join(1100..1309,2450..2546,3044..3139,3297..3355, 3662..3731,4202..4335,4561..4783,6188..6385,8198..8399, 8673..8781,8961..9019,9348..10312) /gene="ENO2" /note="human gamma enolase" gene 1100..10312 /gene="ENO2" exon 1100..1309 /gene="ENO2" /number=1 intron 1310..2449 /gene="ENO2" /number=1 exon 2450..2546 /gene="ENO2" /number=2 CDS join(2462..2546,3044..3139,3297..3355,3662..3731, 4202..4335,4561..4783,6188..6385,8198..8399,8673..8781, 8961..9019,9348..9417) /gene="ENO2" /codon_start=1 /product="human gamma enolase" /db_xref="PID:g31165" /db_xref="SWISS-PROT:P09104" /translation="MSIEKIWAREILDSRGNPTVEVDLYTAKGLFRAAVPSGASTGIY EALELRDGDKQRYLGKGVLKAVDHINSTIAPALISSGLSVVEQEKLDNLMLELDGTEN KSKFGANAILGVSLAVCKAGAAERELPLYRHIAQLAGNSDLILPVPAFNVINGGSHAG NKLAMQEFMILPVGAESFRDAMRLGAEVYHTLKGVIKDKYGKDATNVGDEGGFAPNIL ENSEALELVKEAIDKAGYTEKIVIGMDVAASEFYRDGKYDLDFKSPTDPSRYITGDQL GALYQDFVRDYPVVSIEDPFDQDDWAAWSKFTANVGIQIVGDDLTVTNPKRIERAVEE KACNCLLLKVNQIGSVTEAIQACKLAQENGWGVMVSHRSGETEDTFIADLVVGLCTGQ IKTGAPCRSERLAKYNQLMRIEEELGDEARFAGHNFRNPSVL" intron 2547..3043 /gene="ENO2" /number=2 exon 3044..3139 /gene="ENO2" /number=3 intron 3140..3296 /gene="ENO2" /number=3 exon 3297..3355 /gene="ENO2" /number=4 intron 3356..3661 /gene="ENO2" /number=4 exon 3662..3731 /gene="ENO2" /number=5 intron 3732..4201 /gene="ENO2" /number=5 exon 4202..4335 /gene="ENO2" /number=6 intron 4336..4560 /gene="ENO2" /number=6 exon 4561..4783 /gene="ENO2" /number=7 intron 4784..6187 /gene="ENO2" /number=7 repeat_unit 4977..5260 /gene="ENO2" /note="ALU-like element" repeat_unit 5323..5625 /gene="ENO2" /note="ALU-like element" exon 6188..6385 /gene="ENO2" /number=8 intron 6386..8197 /gene="ENO2" /number=8 exon 8198..8399 /gene="ENO2" /number=9 intron 8400..8672 /gene="ENO2" /number=9 exon 8673..8781 /gene="ENO2" /number=10 intron 8782..8960 /gene="ENO2" /number=10 exon 8961..9019 /gene="ENO2" /number=11 intron 9020..9347 /gene="ENO2" /number=11 exon 9348..10312 /gene="ENO2" /number=12 polyA_signal 10294..10299 /gene="ENO2" polyA_site 10312 /gene="ENO2" BASE COUNT 2285 a 2856 c 3103 g 2661 t ORIGIN 1 ctgcagggga aagttggtgg tgtatgcagc tggacctagg agagaagcag gagaggaaga 61 tccagcacaa aaaatctgaa gctaaaaaca ggacacagag atgggggaag aaaagagggc 121 agagtgaggc aaaaagagac tgaagagatg agggtggccg ccaggcactt tagatagggg 181 agaggcttta tttacctctg tttgtttttt tttttttttt tttttttttt tttttgcgag 241 gtagtcttgc ttagtctcca ggctggagtg cagtggcaca atctcagctc actgcaactt 301 ccacctcctg ggttcaagca attctcctgc ctcagcctcc cgagtagctg ggactacagg 361 cgcatgcaac cgcgcctggc taatttttgt atttttagta gaaacggggt ttcaccacgt 421 tagccaggat ggtctggatc tcctgacctc gtgatctgcc cgcctccgcc ttccaaagtg 481 ctggattaca ggggtgagcc acagcgcctg gtccctattt acttctgtct tctacctcca 541 ggagatcaaa gacgctggcc ttcagacctg atcagactcc caggggcagc caccacatgt 601 atgacagaga acagaggatg cctgtttttc cccaaagctg gaaattcatc acaacctgag 661 gcccaggatc tgctctgtgc cggtcctctg ggcagtgtgg ggtgcagaat ggggtgccta 721 ggcctgagcg ttgcctggag cctaggccgg gggccgccct cgggcaggcg tgggtgagag 781 ccaagaccgc gtgggccgcg gggtgctggt aggagtggtt ggagagactt gcgaaggcgg 841 ctggggtgtt cggatttcca ataaagaaac agagtgatgc tcctgtgtct gaccgggttt 901 gtgagacatt gaggctgtct tgggcttcac tggcagtgtg ggccttcgta cccgggctac 961 aggggtgcgg ctctgcctgt tactgtcgag tgggtcgggc cgtgggtatg agcgcttgtg 1021 tgcgctgggg ccaggtcgtg ggtgccccca cccttccccc atcctcctcc cttccccact 1081 ccaccctcgt cggtccccca cccgcgctcg tacgtgcgcc tccgccggca gctcctgact 1141 catcgggggc tccgggtcac atgcgcccgc gcggccctat aggcgcctcc tccgcccgcc 1201 gcccgggagc cgcagccgcc gccgccactg ccactcccgc tctctcagcg ccgccgtcgc 1261 caccgccacc gccaccgcca ctaccaccgt ctgagtctgc agtcccgagg tgaagccccc 1321 gccaggccca gagcccctgt ggccccctcc cttcgccgcg gcgcccctgc ctcctttacc 1381 cggtgccgct gcgcacctct ccgcatctct ggcccggtgc agctgcgcac ctgctccgcc 1441 gcccgcgccc agggcgcctt ccctccctgg ccttccccgc ccgctgcctt cgctttctgg 1501 ccctctgcgc gcctatctct aactgcgcct ctccaccctt gcctgcctct ctcccggtgc 1561 tcgccctcat ctacgtctat tgttctaagt tggacgtctc cggcgtgcat tttatcctag 1621 agcgtccctt ttggtttgca tttgggaaat gtcttctctc accgttcctc acctccccca 1681 gacttccctt gactcccctc tctcctgctc ttccccacgg cgcccctctc cgttcgcgct 1741 tcctcccctc tgctgcacgg gggagagatg gaagaagtgg ggatctgtcg aggcgcagag 1801 gggaggacag gcccagctcg cctccactcc ccaccggctc ttatcctctt cacttcccgc 1861 tgcaaccccc agggactgca gggcctttct caggaccctc ttccccgaca cctgtattgc 1921 atgcgccttt cgcgggaaga ggagggatac acgtttggga gagagtggga ccttggggaa 1981 ggggcagtgt tcaggcagct ggggtgttaa gttggggagg tatgggggct ctggaagaga 2041 ggcccaggca gcccatcctc ttcttggctc ccaggagaaa tgcaagcctg gcagccattc 2101 cgctctgagg agatctggga acccaccggc tggccaagct gcaaagaggc gcgggaacat 2161 gtcgtgccct ccctcctcac tgcagtgttc tccatctcat catttgatct tacccgcccg 2221 ggactgcagt gacctcccct tcctcactgc attgaccttc tcctcttcca ggggggaggg 2281 ggaatccctt ctacagccct agactgcagc cagcgcctcc ctacccaccc cccacccact 2341 gcagtaacct ctttcccatc cctcccagcc tcccgccccg cccattgatc tcaggctcca 2401 cccctctaag cctcttatct ttctccttcc ttcccttcca cccgaggaga tcccagccat 2461 catgtccata gagaagatct gggcccggga gatcctggac tcccgcggga accccacagt 2521 ggaggtggat ctctatactg ccaaaggtaa tgggtgtggc atgggccttc ctacagccct 2581 agcttttcca cggccaggct gggttcggcc aggggttcgg aggccttttt tgatacccag 2641 gggtatgggg tgctgggcca ggctcacaag cctgggttgt ggcggttgga tcctccttgt 2701 ccgggagcca gggtaggtgg gtctgtgttc gagtttagcg tgtgagcatg tcctgcctcc 2761 gtgtgtctgc ctgtgcactt gcatgtgtgc agacgtgtgc tgcaagcaat tttctttctg 2821 cgggctccca cttgtgcatg tggggcctca gatgggtgga tgaggaggcc acttcttgtg 2881 catctgcctc agtgtgtgtg tggggtgggg gtggggggat gttagggagc agtgtgggga 2941 gagagctaga tgtggtaggc aggcagttta gagccagaag gctgaaggac tccctggccc 3001 ctgtgtcctc ttcactccct ctcattccat gttcctcctt taggtctttt ccgggctgca 3061 gtgcccagtg gagcctctac gggcatctat gaggccctgg agctgaggga tggagacaaa 3121 cagcgttact taggcaaagg tgaggtccct tctcttttcc agactctccc ccacctcagc 3181 cttatgcccc tacctcacac cagtccccag tcctcctcta gcatggcttc ccctcctccc 3241 attgatccct tccgcccctc ctggcccgac ccagtccagc ctcttccttt ccccaggtgt 3301 cctgaaggca gtggaccaca tcaactccac catcgcgcca gccctcatca gctcagtgag 3361 gcctgctctt tgctggggat agcagggcca gagttctgga aggaatcccg gagcagggca 3421 ggaggaaggg aagaaagaag gcccactctt aggaatcatg gttacaaggg ggaagggtgg 3481 ggaacagctt ccttaatgca ccctgctccc atgggagttc aggtccccta atccaggtag 3541 gcccctgtca cagggacctg gttggaccct ggccaaatgt gagcttgggt gtgaatgagg 3601 ggaccctctg ccttaggctc agcctccagc ctggccctgg gtgatggagc tctgccctca 3661 gggtctctct gtggtggagc aagagaaact ggacaacctg atgctggagt tggatgggac 3721 tgagaacaaa tgtgagccgg gccggagaaa gtgggaagcg tcagggtggg gaggcgtgga 3781 gcagatagag agctgaaggg ccagtgctgt agtggcttcc tcaggaatga ctgtcagggg 3841 cattctcctc tcaaagccag agcaagggga gatgagttta gctgcagagg gaaggaccga 3901 cagtaggcag aaggaagacc ttctttgcag catacagagg agggggatgg cctgagagag 3961 tctgtggtct cagggatatt tagaaagagg tgtggctctc tgccgtttcc aatctcctcc 4021 tccccaccca ttcctctccc tgctgttttc aagagagcat ggatgaggtg ttgctggggc 4081 aggggtgggg agggaggagg gggtctcctt tactggctcc ttttggagac tacagatgga 4141 ggcaggagct agaaaggaga aggggacatt tggctcagca ccttcctcta taatctccta 4201 gccaagtttg gggccaatgc catcctgggt gtgtctctgg ccgtgtgtaa ggcaggggca 4261 gctgagcggg aactgcccct gtatcgccac attgctcagc tggccgggaa ctcagacctc 4321 atcctgcctg tgccggtgag caataagcca cggtgcggct ctcccagggg cgggtggggg 4381 agggagcatg caactcatga ggaatgatgg gaggaaagtg aattgaggga ggtaaagagg 4441 aaggatgggg acgtgagact tagtccggaa agctggggga agtttgggat cttgggttaa 4501 cactcctggg gcgggcaggg aggggctctt tgacccttct gtctttctgt ggctccccag 4561 gccttcaacg tgatcaatgg tggctctcat gctggcaaca agctggccat gcaggagttc 4621 atgatcctcc cagtgggagc tgagagcttt cgggatgcca tgcgactagg tgcagaggtc 4681 taccatacac tcaagggagt catcaaggac aaatacggca aggatgccac caatgtgggg 4741 gatgaaggtg gctttgcccc caatatcctg gagaacagtg aaggtgaggc caggagcccc 4801 actcccagcg tgctaagtct taccctattg tgggacatca gaaagggtga cacagttcac 4861 caagtcctga gtaggcgtgg agggtcctag gactctgcaa actccaaaag gtaccagttc 4921 ttagagtgga ttgcagagag cctgccaaat tcacatgcag acctaggggg acagtatttt 4981 tttttttttt tgagacggag tcttgctctg tcacccaggc tggagtgcag tggctcgatc 5041 tcagctcact gcaacgtccg cctcccgggt tcacgccatt ctcctgcctc agcctcccga 5101 gtagctggga ctacaggcgc ccgccaccac tcccggctaa ttttttgtat tttttagtag 5161 agacagggtt tcactgtggt ctcgaactcc tgaccttgtg atcggcccgc ctcggcctcc 5221 caaagtgctg ggattacaag cgtgagccac cacgcctggc caggggacag tcttttacct 5281 gcctagccag atgtgttagc atctgttaag ttgccactgg aaggccgggc gcggtggctc 5341 acacctgtaa tcccagcact ttgggaggct gaggcgggtg gatcacctga ggtcaggagt 5401 ttgagaccag cctggccaac aaggtgaaac cccgtctcta ctaaaaatac aaaaattagc 5461 cgggcatggt ggcgtgtgcc tgtaatcaca gatactagcg gggctgaggc aggaggatcg 5521 cttgtacccg ggaggcggag gttgtggtga gccgagatca tgccactgca ctccagcctg 5581 ggcaacagag cgagctccgt ctcaaaaaaa aaaaaaaaaa aaaaagttgt cactggagcc 5641 cttgggaata ctgggagatg gtctggatga cctgttggat tcatcccatc ccattcgaaa 5701 tctgtcctgt ccccgtccca acctcctagg cctctagaat ccctaatttt tctgtgcctt 5761 gggggaaact gtatagggaa tggaaagaat ataggtagtg gttaagagtt aaggttctgg 5821 ggccaaataa cctggattta tttgaacctt gacttgtgga gttactgctg gtgaactttc 5881 ttacttctct ctggaaataa taacagaatc tagctcatgg tagtgtgagg cttaaatgaa 5941 atatatataa aatgcttaga tgacatgata ccaatgaaag tatagtaagt attattaaga 6001 gaattccatt cctctgtgtt cctagaagat ggcctctcct ccagacctgg gataacccca 6061 acagcatccc cgccacactt ccctcaggaa cagacctcca cctctgccct gaatgtcttt 6121 tctttccctc ctcctccttg cccatccctc ctgcttgtac tataatctca ctgtattctg 6181 tccccagcct tggagctggt gaaggaagcc atcgacaagg ctggctacac ggaaaagatc 6241 gttattggca tggatgttgc tgcctcagag ttttatcgtg atggcaaata tgacttggac 6301 ttcaagtctc ccactgatcc ttcccgatac atcactgggg accagctggg ggcactctac 6361 caggactttg tcagggacta tcctggtgag aggaagtggt gtgaggggga ggtctggggg 6421 caggcaggga cgtgtcccag caactctgga ccttatgggg tgctgactca ggcaccaggt 6481 gggggtgtcc taagaagaac ctgagaacca gggagagggt gcaggagcca cctgcaaaga 6541 ctgggctttg tatgtagtgt aaaaaatgca ggtacccgtg accaatctgt tctgtctcag 6601 atcctgatta aagtcatggg ttctgaaaac tactggggtc atggggaagg ctctggaagg 6661 aaccagggat gatatgagtg tgactggatc tagcagagaa ctagaacatt tcagtatctt 6721 tgattgatga aattgtggat gctgaatgga gctgggactg atgtgtgagt agaaagaagg 6781 ctgaggggga ctgaattagc ttctgcaagt ctgcccaggg cctttatctc aggatggagg 6841 cagttggtcg ccatcttcct gacacagagc gaaagaaaat caacataatt gcagaattaa 6901 ggatttggat tagcaatgag gaagggcttg ctggcagtga gaacaggaaa atgcaaagct 6961 aggttgtgaa cccttgttac tggaagattt tttttggggg gggggtgggg ttgttttttt 7021 tgttttgttt tttttttttg agacagagtt tgactcttct tgcccaggct ggagtgcaat 7081 ggcgccatct cggctcacca caacctccac tcccggattc aagcgattct tctgcctcag 7141 cctcccgaat agctgggatt acagcatgtg ccaccatgcc tggctaattt tgtattttta 7201 gtagagacag gggtttctcc atgttggtca ggctggtctc caactcctga cctcaggtaa 7261 tctatccacc ttggtctccc aaagtgctgg gattacagcg tgagccacca cgcctggctg 7321 gtttgctttt aattaacttt tttttttttt tttttttttt gtagagacag ggtttaccat 7381 gttgctcatg gctggtctca aactactggg ctcaagtgat ctgcatgcct cggcctccca 7441 aagtgctggg attacaggca tgagccactg tgcccagcct atggaagtgg cgtgagatct 7501 ctgctcactg cacgattctc ttagcctccc aagtagctgg gattacaggc gtgcaccacc 7561 atgcctgcta atttttgtat ttttagtaga gatggggttt tactatgtta gccagggaac 7621 tcctatcctc aagtgatccg ttcacctcag tatcccaaag tgctgggatt acaggcatga 7681 gccactgtgc ctggcctctc catgtaaggt tttatgaaat aagaatcagg agccaggcgt 7741 ggtgctcatg cctgtaatcc cattactttg ggaagccgag gcaggaggac tgcttgaatc 7801 caggagttcg agactggcct ggcaatacag tgagacctca tctctacaaa aattttaaaa 7861 attagctgag tgtggtgcca cacacctaaa gtccctgcta ctcaggaggc tgaggtggca 7921 ggatcacttg attggggagg tggaggttgc agtgagctga gattgtgcca ctgcactcca 7981 gcctggatga cagaatgagg ctctgtcaaa aaaaaaaaaa aagttaagaa tcagttaggg 8041 caggcttaca ctggggggat ttgtcttagc aaggatgagc aggtgtagtt aaccaagggc 8101 ctgtccattt cagggaataa aggggcatgt tcctgcctga tgtagagacc cagggaagat 8161 gaacacctcc cccctcccca ccatgctctc tctgcagtgg tctccattga ggacccattt 8221 gaccaggatg attgggctgc ctggtccaag ttcacagcca atgtagggat ccagattgtg 8281 ggtgatgacc tgacagtgac caacccaaaa cgtattgagc gggcagtgga agaaaaggcc 8341 tgcaactgtc tgctgctcaa ggtcaaccag atcggctcgg tcactgaagc catccaagcg 8401 tgagtgactt ctggccctct cctgtgtggt cctcgtttct ataagactcc ttttgcaagt 8461 gctccagcct aattctaccc aggggtgcca aagagagcgg ggaacctgga atcatcctca 8521 cagttctctc acctctgccc ctccacccct gattctctgc tcccctccca gatagctttc 8581 ccctagatgt ttcctgacat agaccaaggt tggggctggg aagagagtgc ccagtgtgag 8641 agctggagaa tcagtgctgt gtgtggatac aggtgcaagc tggcccagga gaatggctgg 8701 ggggtcatgg tgagtcatcg ctcaggagag actgaggaca cattcattgc tgacctggtg 8761 gtggggctgt gcacaggcca ggtgagtgag gcagcctggt gagtgaagag aactctctgt 8821 gggattggta tttctagctc acccacctgg tctctccttc caggtgtttg agggtgtcag 8881 gggagtttca ggagagcaga agtttccttt caggggtgag agggcagtca ctgagctgca 8941 aatcctttga aatgtttcag atcaagactg gtgccccgtg ccgttctgaa cgtctggcta 9001 aatacaacca gctcatgagg tgagggtccc tggggtggga gcccctggcc cagatggcta 9061 aaggccccat ttgcctgcca gaccatctgt agcaccaagg gcctggataa cagtccattt 9121 cctggataac agtccaacag ataatattgg tttttgcttc ctgggtttat tgatggcctg 9181 attgacaaat cccagagatc acatgggaaa gccagggaat gctaagcctt ggggcaggac 9241 acaaaagcag gtggtgtggg ggtggttgga gtctggggga cccctagaga gagaagcagg 9301 atcctcctgc atccctgacc acttcctttg tggttcatct ctctcagaat tgaggaagag 9361 ctgggggatg aagctcgctt tgccggacat aacttccgta atcccagtgt gctgtgattc 9421 ctctgcttgc ctggagacgt ggaacctctg tctcatcctc ctggaacctt gctgtcctga 9481 tctgtgatag ttcaccccct gagatcccct gagccccagg gtgcccagaa cttccctgat 9541 tgacctgctc cgctgctcct tggcttacct gacctcttgc tgtctctgct cgccctcctt 9601 tctgtgccct actcattggg gttccgcact ttccacttct tcctttctct ttctctcttc 9661 cctcagaaac tagaaatgtg aatgaggatt attataaaag ggggtccgtg gaagaatgat 9721 cagcatctgt gatgggagcg tcagggttgg tgtgctgagg tgttagagag ggaccatgtg 9781 tcacttgtgc tttgctcttg tcccacgtgt cttccacttt gcatatgagc cgtgaactgt 9841 gcatagtgct gggatggagg ggagtgttgg gcatgtgatc acgcctggct aataaggctt 9901 tagtgtattt atttatttat ttattttatt tgtttttcat tcatcccatt aatcatttcc 9961 ccataactca atggcctaaa actggcctga cttgggggaa cgatgtgtct gtatttcatg 10021 tggctgtaga tcccaagatg actggggtgg gaggtcttgc tagaatggga agggtcatag 10081 aaagggcctt gacatcagtt cctttgtgtg tactcactga agcctgcgtt ggtccagagc 10141 ggaggctgtg tgcctggggg agttttcctc tatacatctc tccccaaccc taggttccct 10201 gttcttcctc cagctgcacc agagcaacct ctcactcccc atgccacgtt ccacagttgc 10261 caccacctct gtggcattga aatgagcacc tccattaaag tctgaatcag tgcactgttg 10321 tgtctaagga gtcttactct agtccctatg aggggagaga agatggagca cctggaagct 10381 ggtgaaactg gatagcagag ctgggggggc acaaaaagag gaagacaaac tgaacaaata 10441 tggccgagat gatggcactg cctaccccat tctggctagg tggggtgcat gtggcccctg 10501 ctttcttagc agaaggcttg gctcccagac gcaggtgaat taaggggttc aagagcccct 10561 aaaagcataa aatattttgt gtgtgtgtgt gtgtgcacgc gcattttggg ggaaaggggg 10621 tctaaggtgt tttcatatcc aaagggcttg tggactggag cagctcctgt actgggcctc 10681 tgccaacaaa accctggctg gttctcgaat ggaacaggac ttcatggcca tcacccactg 10741 caagatgggg aaatgggaag gaagaatggt tccgggggta gtatacggaa ggacctaagg 10801 aaacagagtc ctcaataaac tgaagattca ggaacaaaag tgcttaacag aaccctggct 10861 gggtcagact aacagtaggt ttccaatatg tggctagaga cgtac //