LOCUS HSFOLA 6045 bp DNA PRI 31-OCT-1996 DEFINITION H.sapiens gene for folate receptor. ACCESSION X69516 NID g288876 KEYWORDS folate; folate-binding; gene family; membrane glycoprotein; transport. SOURCE human. ORGANISM Homo sapiens Eukaryotae; mitochondrial eukaryotes; Metazoa; Chordata; Vertebrata; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 6045) AUTHORS Elwood,P.C. TITLE Direct Submission JOURNAL Submitted (12-NOV-1992) P.C. Elwood, National Institute of Health, Bldg 10 Room 12N 226, 9000 Rockville Pike, Bethesda, MD 20892, USA REFERENCE 2 (bases 1 to 6045) AUTHORS Page,S.T., Owen,W.C., Price,K. and Elwood,P.C. TITLE Expression of the human placental folate receptor transcript is regulated in human tissues. Organization and full nucleotide sequence of the gene JOURNAL J. Mol. Biol. 229 (4), 1175-1183 (1993) MEDLINE 93188012 REMARK Erratum:[J Mol Biol 1994 May 13;238(4):639] COMMENT Related sequence: J02876. FEATURES Location/Qualifiers source 1..6045 /organism="Homo sapiens" /db_xref="taxon:9606" /clone_lib="human lymphocyte EMBL3" GC_signal 89..99 GC_signal 94..104 TATA_signal 197..204 CAAT_signal 296..304 TATA_signal 385..392 misc_feature 495..499 /note="Ets motif (Pu box)" misc_feature 553..558 /note="Ets motif (Pu box)" misc_feature 559..565 /note="Ets motif (Pu box)" exon 611..737 /gene="placental folate receptor" /number=1 mRNA join(611..737,2383..2556,4687..4875,4993..5128,5287..5758) /gene="placental folate receptor" gene 611..5758 /gene="placental folate receptor" intron 738..2382 /gene="placental folate receptor" /number=1 GC_signal 802..902 /gene="placental folate receptor" exon 2383..2556 /gene="placental folate receptor" /number=2 CDS join(2407..2556,4687..4875,4993..5128,5287..5579) /gene="placental folate receptor" /codon_start=1 /product="folate receptor" /db_xref="PID:e279925" /db_xref="PID:g1655592" /translation="MVWKWMPLLLLLVCVATMCSAQDRTDLLNVCMDAKHHKTKPGPE DKLHDQCSPWKKNACCTASTSQELHKDTSRLYNFNWDHCGKMEPACKRHFIQDTCLYE CSPNLGPWIQQVNQSWRKERFLDVPLCKEDCQRWWEDCHTSHTCKSNWHRGWDWTSGV NKCPAGALCRTFESYFPTPAALCEGLWSHSYKVSNYSRGSGRCIQMWFDSAQGNPNEE VARFYAAAMHVNAGEMLHGTGGLLLSLALMLQLWLLG" intron 2557..4686 /gene="placental folate receptor" /number=2 exon 4687..4875 /gene="placental folate receptor" /number=3 intron 4876..4992 /gene="placental folate receptor" /number=3 exon 4993..5128 /gene="placental folate receptor" /number=4 intron 5129..5286 /gene="placental folate receptor" /number=4 exon 5287..5758 /gene="placental folate receptor" /number=5 BASE COUNT 1507 a 1429 c 1515 g 1594 t ORIGIN 1 tttacatgtg tccaggaggt ctcgaacctc tgacctcagt gatctgtctg cctcagcctc 61 ccaaagtgct gggattactg acgtgagcca ccatgcccag cctatacctc aacttctacc 121 tatgtccacc tggctgccca taaattaacc caatagctgt cacttaagcc tactcagtat 181 gtgccaggct tttccctata caattgtgaa caattttcta gtgagcaaac tgaagctcag 241 taaggtccag tgacttttcc caaggttgtg caagagatgg agctctcatt gggtcccatt 301 ggcctgaccc taaagcctgg gttcttttcc accagaccta atctccatcg agctggcctt 361 atcctaagaa ccacttgggg tatctataaa atccagatgc cccctggtga tgagcaattc 421 tctagatttt gatgaaagtt gaatgtgtgg atgctggaat gagtaaatta acaagtaagg 481 agatgaatgc aagcaggaat gactaaatgg acagactcag ggagccttga agagggtggg 541 gtctggaagg gaaggaagag aggaaggaga atagctaagt agggagattt cactcagtgc 601 ttaccagagc gcgttgtcta ccctgtaccg aagacagagg ctgtggggac agcctagggg 661 cctggatcta ttgcctactt agagagaggc caactcagac acagccgtgt atgctcccag 721 cagcaacgga ggttcaggca agatgcccga aggagggaag ggtgacaagg gcagtgggga 781 gacttggaga gtttgtgcag aggggaggaa cacacctttc tttctgtatt gtattgtatt 841 gtattgtatt ttttgagaca gagtctcgct ctgtcaccca ggctggagtg cagtggcacg 901 atcttggctc actgcaacct ctgcctcctg ggttcaagtg attctcctgc ctcagcctcc 961 tgagtagctg ggattacagg tgcccaccac ctcgcctggc taatttttgt atttttagta 1021 gagacggggt ttcatcatgt tggtcaggct ggtctcgaac tcttgacctc aggatccacc 1081 cacctcggcc tcccaaagtg ctgggattac aggcgtgagc cactgtgccc ggccacatct 1141 ttctttagaa agatcatgct ggctcctgtg gggaaggcaa cttgaagggg aagaaattgg 1201 aagagggaag acttgacact aaacatagag ccatggtcag taagtttttg gagggacctt 1261 taccagagag ggagaggaag cagtatccat tatccactct ttagtgacag agcccaaagg 1321 aacagctctg taatggctgg gggtgggggc aagggcagca atgaacagag gaggcgaggg 1381 ctgctcctgt tgttgagtgc cttccaggac actaagtgct ggtctggctg ctccaacatg 1441 ggaaactttc atgttgtctc tcagatctaa gggtctctct gcatttttaa aaaaattatt 1501 ttgaattttt taaacttcta tcgtttttca ggtggttttg gttgcataga taagttcttt 1561 agtggtgatt tctgaatttt agtgcaccag tcaccggagc agtgtacact gtactcagta 1621 tatagtcttt tattcctcac cccctcctca ccttgcccca ccttgcccca cccccagtct 1681 atatcattct catctgcatt tgttttttga gaggtagggt gaggtctgct gcattagccc 1741 agagacagct gaggaggctg gaaaggaaaa tggctttcag agaataggga aggaaaaagt 1801 ctgaggaagc aaaactactt aaaaaacact gctctttcca tttccgtatc atttaaccaa 1861 acaccatcct gtgggttctg tcacttgatc ctcatgctga tctgagaact cggcagagct 1921 gggtcactgc cttccccaag gctaacctgg tttctaagct ggcacaagac cccaggtgat 1981 ctatcatcta accacagagc ccttgctgga cagagggtga agacattatg tgtccctggc 2041 tctgttcagg gaagcagagg atagacctga aggaatttaa ttacttgtca tagataaagc 2101 ctagagaaaa ggtgagggcg caaagtatct cctccaaatt gggaagactc ccccagggct 2161 cactcactaa cgccagttct cctgagcctt taaagcctgg gggtgaggga gccctcctgg 2221 tcaaccctct ctaccctagc ctcagggagc ttcagggccc cagcattgaa ggaacagggt 2281 ctgacctcat ttgccaccgt agggatgggg agactgaggc aggaggtgaa tggctcccag 2341 cttggagccc tttcccctca ggacttggtt tccctaccct agctccgcct gcagggacag 2401 aaagacatgg tctggaaatg gatgccactt ctgctgcttc tggtctgtgt agccaccatg 2461 tgcagtgccc aggacaggac tgatctcctc aatgtctgta tggatgccaa gcaccacaag 2521 acaaagccag gtcctgagga caagctgcat gaccaagtac ggctggagtg tgcctctgct 2581 aaggaggggg cttgttctaa cagggaggag aaagtcagga tggtgggaga gggattgagg 2641 ggtcagatac ctccacatcc tgaagttttc ctgtgggaga agatgaaggt ggagtaggaa 2701 gagtggctga ggtgatttta ggggggccct ccccggaggt ggataccatg ttgacaatga 2761 tattgagtcg tcattcgatg ggcacctgtc agttgtcatg tgttttttgt acaaaatttc 2821 atattcccag gggttcttgg atgtaggtag atgatattct ccacattaca caagtaagtg 2881 aaaatgaggc tcacagaagc acatgggccc acacaggagc tggacatgaa tggcccctgt 2941 ggagggtagg aataggagtg ggttaggctc ctcctttggt gggtgacaga ctagggagtc 3001 gctggctttt cccaccctca ctaagtgcca tttccatgga gtgccaaggg agaagaggag 3061 gaggcccttc tggctgtaat ttgaggcaca ggggctggac attcacacag tctatataca 3121 tgtatgccag gggattgcag ccttattaga ctcaatgtct cccttttatg acagattttt 3181 ttttagattc tcttttctat cctgcaatga aattcaaaga acctatttgt atgcataatt 3241 tttgcaaata tcaacataat gctctgtaat ataaaggaga aacacacaga agtaacttgt 3301 aataaaataa tatatatttc aatatgtcag ttctctggta tgactacatt agaaggcatt 3361 aggaaatagc acatgcttgc ttttgtcata aaatcattat aagtggggag ctacaaatga 3421 agattgatac aggtatattc tattggtgac ttaaacacta taagatacta taatataagc 3481 aatgttgctg ttgatgtcat acttttctaa aatagtgaat aattctagta gaataaacca 3541 catagtacag ccttctattt catggtattt gcagtcctgg aaaacccagt ctagattaaa 3601 atcttgtgaa aacatgatgt gcctatatgt aagatagaga tacatttaaa aagtagggct 3661 tttgcttact tttttttttt tttttgagaa ggagtctcac tctgttgccc aggctggagt 3721 gcaatggtgt gatctcagct cacggcaacc tccgctccgg ggttctggtg attctcctgc 3781 ctcagcctcc caagtagctg gggcacccgc caccatgcct ggctaatttt tttgtatttt 3841 taccagagac gaggtttcac catgttggcc agggtggtct caaactcctg acctcaggtg 3901 gtagacctgc ctcggcctcc caaagtgctg gggttacagc tacgagccac cacgcccagc 3961 ctggcttttg cttacttttt ccagcaaata ttttcatggg cctactatgt gtctggcact 4021 gcctagccac tgggacacag atcttactac atgccaagaa gaataaatat attcaaactc 4081 cattacacca tggctcgctc cctctcttcc tttgctcaaa atgtcaccaa tgtggcattt 4141 cctaacctat ttaaaatttc agcaattcca cattaccatt tcctgctcat atcatttaac 4201 ttttcccata tcatttatca tatcctgaca taccatatat atatattttt taagtttctt 4261 actgtctgtc tcctctgacc agaatgaaaa ttccatgaat acatatttct gtctgttttg 4321 ttctcttctg tattcccagc atctataacc gtgactggca taaagtaggt gctcaataat 4381 ttttaaatga gtaagtgaaa ggacttttta tgaagtgtta catacctcat aaatgataac 4441 tattattccc aagacagggt ttcccctggg ctcccacagt cccctgatca cacggttgta 4501 attgtgtttc ctccaagaaa ggggttcctg gaggcctagg agagagggac catcatctgg 4561 gaacctgagt gttctcagga caacctgcct agggcagagg agtaagaacc aaatggggga 4621 gagacacgag gtggcaggag gaggagggta tggggaggca cttagtcctg tgtcttcccc 4681 acccagtgca gtccctggaa gaagaatgcc tgctgcacag ccagcaccag ccaggagctg 4741 cacaaggaca cctcccgcct gtacaacttt aactgggacc actgcggcaa gatggagccc 4801 gcctgcaagc gccacttcat ccaggacacc tgtctctatg agtgctcacc caacctgggg 4861 ccctggatcc agcaggtagg gtgtctcccc cccacccacc ccagcagact gccatccccc 4921 tcagtcactt caaggcgatg gctgccagca tccctggctg agaggagccc tgcctcccca 4981 cctcccaccc aggtgaatca gagctggcgc aaagaacgct tcctggatgt gcccttatgc 5041 aaagaggact gtcagcgctg gtgggaggat tgtcacacct cccacacgtg caagagcaac 5101 tggcacagag gatgggactg gacctcaggt gagggtgatt gagttggggt taggaaaaag 5161 gagattgagg tagggtttgg aaaatcctca aggatttggg gtggggtgaa gatttctggg 5221 ggtggccaga aatgagcttt gggcccaggg gctgaaagtc tgtgtccacc atgcctctcc 5281 ctgcaggagt taacaagtgc ccagctgggg ctctctgccg cacctttgag tcctacttcc 5341 ccactccagc tgccctttgt gaaggcctct ggagtcactc atacaaggtc agcaactaca 5401 gccgagggag cggccgctgc atccagatgt ggtttgattc agcccagggc aaccccaacg 5461 aggaagtggc gaggttctat gctgcagcca tgcatgtgaa tgcaggtgag atgcttcatg 5521 ggactggggg tctcctgctc agtctggccc tgatgctgca actctggctc cttggctgag 5581 ttcagtcctc ccagactacc tgccctcagc ttggataacc aggctgggct cagctcagct 5641 cccacaaatg acagcccctt aagcatgctt ctattagtca cctaaccctc tgtcacccag 5701 tctgttgctg ctccatggtg gggccaagag tcacttctaa taaacagact gttttctaat 5761 aattccatgt ctgtggaatt gttttggttg tgagtttgtg ggtgggtggg agacagattc 5821 tacggcttct ggattccttc aaattagagc aactagacct gtgtttgaat cccagctctg 5881 ctactttgtg aaaatgaaac agttgcttca ctgctctaaa cctttgtttc cttctggata 5941 aaaagaggat aatagtcctg ccctcaggct tgtgaaatat acaggagctg ttgcctagaa 6001 agcccgtgag cccagtgtct gcacattaat agtcttcagg gatcc //