LOCUS HSGLA 12436 bp DNA PRI 25-JUN-1997 DEFINITION Human GLA gene for alpha-D-galactosidase A (EC 3.2.1.22). ACCESSION X14448 NID g31755 KEYWORDS alpha-D-galactosidase A; Alu repetitive sequence; galactosidase; GLA gene; glycoprotein; hydrolase. SOURCE human. ORGANISM Homo sapiens Eukaryotae; mitochondrial eukaryotes; Metazoa; Chordata; Vertebrata; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 12436) AUTHORS Bishop,D.F. TITLE Direct Submission JOURNAL Submitted (25-FEB-1989) Bishop D.F., Mount Sinai School of Medicine, Division of Medical and Molecular Genetics, Box 1203, 100th St and Fifth Avenue, New York, NY 10029, U S A REFERENCE 2 (bases 1 to 12436) AUTHORS Kornreich,R., Desnick,R.J. and Bishop,D.F. TITLE Nucleotide sequence of the human alpha-galactosidase A gene JOURNAL Nucleic Acids Res. 17 (8), 3301-3302 (1989) MEDLINE 89263745 COMMENT library=lambda EMBL3; clone=L-W2, L-B5 and L-B18; Data kindly reviewed (16-June-1989) by Bishop D.F. FEATURES Location/Qualifiers source 1..12436 /organism="Homo sapiens" /db_xref="taxon:9606" /dev_stage="adult" /cell_type="lymphoblast" /chromosome="X" /map="q21.33" repeat_unit 848..857 /note="direct repeat 1" /rpt_type=DIRECT repeat_unit 864..873 /note="direct repeat 1" /rpt_type=DIRECT repeat_unit 881..890 /note="direct repeat 1" /rpt_type=DIRECT repeat_unit 897..906 /note="direct repeat 1" /rpt_type=DIRECT TATA_signal 1089..1094 prim_transcript 1120..11266 exon 1120..1373 /number=1 mRNA join(1120..1373,5094..5268,7269..7446,8321..8412, 10131..10292,10510..10707,10978..11266) CDS join(1180..1373,5094..5268,7269..7446,8321..8412, 10131..10292,10510..10707,10978..11268) /EC_number="3.2.1.22" /codon_start=1 /product="alpha-D-galactosidase A" /db_xref="PID:g31756" /db_xref="SWISS-PROT:P06280" /translation="MQLRNPELHLGCALALRFLALVSWDIPGARALDNGLARTPTMGW LHWERFMCNLDCQEEPDSCISEKLFMEMAELMVSEGWKDAGYEYLCIDDCWMAPQRDS EGRLQADPQRFPHGIRQLANYVHSKGLKLGIYADVGNKTCAGFPGSFGYYDIDAQTFA DWGVDLLKFDGCYCDSLENLADGYKHMSLALNRTGRSIVYSCEWPLYMWPFQKPNYTE IRQYCNHWRNFADIDDSWKSIKSILDWTSFNQERIVDVAGPGGWNDPDMLVIGNFGLS WNQQVTQMALWAIMAAPLFMSNDLRHISPQAKALLQDKDVIAINQDPLGKQGYQLRQG DNFEVWERPLSGLAWAVAMINRQEIGGPRSYTIAVASLGKGVACNPACFITQLLPVKR KLGFYEWTSRLRSHINPTGTVLLQLENTMQMSLKDLL" sig_peptide 1180..1272 mat_peptide join(1273..1373,5094..5268,7269..7446,8321..8412, 10131..10292,10510..10707,10978..11265) /EC_number="3.2.1.22" /product="alpha-D-galactosidase A" intron 1374..5093 /number=1 repeat_region 2851..3150 /note="Alu repetitive sequence" repeat_region 3155..3443 /note="Alu repetitive sequence" repeat_region 3828..4125 /note="Alu repetitive sequence" misc_feature 4211..4512 /note="Alu repetitive sequence" exon 5094..5268 /number=2 intron 5269..7268 /number=2 repeat_region 5351..5644 /note="Alu repetitive sequence" repeat_region 5759..6060 /note="Alu repetitive sequence" repeat_region 6306..6595 /note="Alu repetitive sequence" exon 7269..7446 /number=3 misc_feature 7317..7322 /note="pot. N-linked glycosoylation site" intron 7447..8320 /number=3 misc_feature 7945..8229 /note="Alu repetitive sequence" exon 8321..8412 /number=4 misc_feature 8350..8355 /note="pot. N-linked glycosylation site" intron 8413..10130 /number=4 repeat_region 9508..9793 /note="Alu repetitive sequence" exon 10131..10292 /number=5 misc_feature 10137..10142 /note="pot. N-linked glycosylation site" intron 10293..10509 /number=5 exon 10510..10707 /number=6 intron 10708..10977 /number=6 exon 10978..11266 /number=7 misc_feature 11203..11208 /note="pot. N-linked glycosylation site" misc_feature 11211..11215 /note="snRNP binding site" polyA_signal 11250..11255 polyA_site 11266 /note="polyA site" misc_feature 11330..11620 /note="pot. N-linked glycosylation site" misc_feature 12101..12398 /note="pot. N-linked glycosylation site" BASE COUNT 3308 a 2864 c 2649 g 3615 t ORIGIN 1 cccttctgta ggggcagaga ggttctactt cattactgcg tctcctggga aggccatcag 61 gactgctggc taaagtggga accaggactc tttgtgagtt aagaatttgt gtatttatat 121 gtgtgttata cacatttttt aaaaaactgt aacgacatca ggttgagcag tcgtctccgg 181 gtggtgaatt atgtgtattt ttaaatttta tactatattg ttatttttca aatgttcgaa 241 attgaatatg tagattgttg ttatcagcag aaaaataaac attattcaaa tactctattc 301 agtaaagtaa tttattgggc gcctttgtca agcacgcatt tgcctagatg tgactctaca 361 gataaaattc acttggggcc tccccttaca gacaatcagg cagtggagac tgagtgcctg 421 aatggataga ccagcactca gaccactatt ttcagtatct gtttttctta actcagggcc 481 gtggttttca aacgtttttc gccttacggt cacccttagg gtcccccgag accggcccag 541 acagacagat atacaaaaac acatacacag tcatgagcgt ccaccatttc cccaccaggc 601 gcagcacagg cggcttcccg gcactgagat gggggggagg agggagagag cgcgaggggg 661 gaggggaaag cagagaacga aagaggcgga ggcggccccc gaaccccgct ctggtcttca 721 tcatcaccac ccctgggtcc ccagttccca cccacacacc aacctctaac gataccgggt 781 aattttcctc cttcttccct caaacggcta tagcgagacg gtagacgacg accagaacta 841 cttctgctca cgtaagcgag taatcacgtg agcgcctacg tcatgtgaga tctcggtcac 901 gtgagcaact ctcggcttaa actcgggatc actaaggtgc cgcacttcct tctggtatgg 961 aaatagggcg ggtcaatatc aagaaaggaa gagggtgatt ggttagcgga acgtcttacg 1021 tgactgatta ttggtctacc tctggggata accgtcccag ttgccagaga aacaataacg 1081 tcattattta ataagtcatc ggtgattggt ccgcccctga ggttaatctt aaaagcccag 1141 gttacccgcg gaaatttatg ctgtccggtc accgtgacaa tgcagctgag gaacccagaa 1201 ctacatctgg gctgcgcgct tgcgcttcgc ttcctggccc tcgtttcctg ggacatccct 1261 ggggctagag cactggacaa tggattggca aggacgccta ccatgggctg gctgcactgg 1321 gagcgcttca tgtgcaacct tgactgccag gaagagccag attcctgcat caggtatcag 1381 atattgggta ctcccttccc tttgcttttc catgtgtttg ggtgtgtttg gggaactgga 1441 gagtctcaac gggaacagtt gagcccgagg gagagctccc ccacccgact ctgctgctgc 1501 ttttttatcc ccagcaaact gtcccgaatc aggactagcc ctaaactttc tctgtgtgac 1561 ctttcctggg atgggagtcc ggccagcggc ccctgtttct ttctctctct ctctctctct 1621 cgttctcctt ctctttctct ttctcttctt tcctctctct ttctctctct ccctgcccgg 1681 ttctcttttt tcactgctcc ttgcagagca gggccacccc ataggcagtg tgcccaaagt 1741 agccctgccc ggttctattc agacccttct tgtgaacttc tgctcttcct ctgccgggtg 1801 ctaaccgtta gaacatctag ggtgggtagg aggaatgggg aactaagatt cgtgccattt 1861 tttctccttt tggggtcgtg gatttctcgg cagtatctcg agggagttag agagaccata 1921 aggtcgctga gatctctccc acctcgccca tgagcgtggc atcaggctgg aaggttgaca 1981 tggaggaact ttatacattt acacctttgc gtgagggttg aggctggatt agataggtat 2041 tgaacatatc tgaccctcac aatccttatc tgtaaattgg gattacaacc ttttaatttc 2101 agggagctga caaaaaaaat ctgaaaaata gttcttatct cacacaggtg agttttcaag 2161 gagataacct atttaaagta catagcacag cgcttgacca ttcaactgcg cttacagagc 2221 aaatgttcaa tgggaaaatg aatgtaaatc tacaaatctg aatgaatatg tgtatttttc 2281 tggagagagg atatttacct ttcttcaaat tctcaaaggg ctctgtgatt taaaaaaggt 2341 taggaatcac tgatagatgt tggtaaaagg tggcagtcac agtacatttc tgtgtccata 2401 agttattcct atgaatatct ttatagataa agtcaggatg ttggtcagac atcacagaag 2461 aaattggcct tgtaagtttc atgtgaccct gtggtacagt atgtgtggca attttgccca 2521 tcacggattt ttttttattg gtatttgcat ctgattataa aactaatgca tgatcattgc 2581 aaaaaatgta gataaagaag agcaaaatga aaataaagat ttccccccac cgttccacca 2641 cccagaaata atcatggttt aaatgttaat atacaacctt acaattgttt tctatataaa 2701 tgaaaacata gatttcttta tttcattatt ttccataaaa aatggatcat gtttatgtca 2761 tgtttggcta atggcaagac cctggcaccc agtctgggct caaattctgc ctcattgtta 2821 cttagccctg tgacattggg taaattacac tttttttttt tttttttttt tgagacgggg 2881 tctcgctctg tcgcccaggc tggagtgcag tggcacgatc tcggctcact gcaagtccgc 2941 ctcctgggtt cacgccattc ttctgcctca gcctcccgag tagctgggac tacaggcgcc 3001 tgccaccacg cctggctctt tttttttttt tttttttttt tagtacagac ggggtttcac 3061 catgttagcc agggtggtct caatctcctg acctcgtgat tcgcccgcct cagcctccca 3121 aagtgctggt gtgagccacc gtgcccagcc ttactttttt ttttgagagg gggtctcact 3181 ctgtcaccca ggttggagtg cagtggcgcg atctctgctc agtgcaaact ccacctcccg 3241 ggtttaagca gttctcctgt cgtagtctcc tgagtagctg ggattacagg cacaccacca 3301 cggccagcta atttttgtat tttcagtaga gacgggtttc accatgttgc ccaagctggt 3361 ctcgaactcc tggcctcaag tgatctgccc gccttggcct cccagagtgc tgggattaca 3421 ggtgtgagcc accgcacccg gcctcttttt tcttttttag tctatcatac cttgcaaata 3481 cagtggttct tcctatgtgt tggttttgat atttatgtaa tcaaacacat cagtttttcc 3541 tttctgattt ctgactttgg ggtcatgctg agaaagtcct ttcctacctg aagataatac 3601 agtatatacg tttcttacta gtatttttgt ggatttttaa aatatttaaa tctttagtcc 3661 atctgaactt gttcttctat cagaaatgcc acatttaata aataataagt cccatggtat 3721 cagatggctg gaaggacctc tttcgaaact ttgtttaatt ccattaatct gtgtattctt 3781 attctaatgc taatagttcc acactagctt cctttatctt ttttttcttt tttttttttt 3841 ttttgagctg gagtttcgct cttgttgccc aggctggagt acaatgtcac gatctcggtt 3901 caccgcaacc tccgcctccc aggttcaagc aattctcctg cctcatcctc gcgagtagct 3961 ggaattacag gcatgcgcca ccacgcctag ctattttgta tttttagtag agatggggtt 4021 tctccatgtt ggtcaggctg gtctcaaact cccagcctca ggtgatctgc ctgcctcggc 4081 ctcccaaaat gctgttatta caggcgtgag ccaccacgcc cagccttcat cttttaatga 4141 atgtacatgt atgtaatctt ttaggtgaac tttttgtaat gttgtgccaa gttccttaaa 4201 aagccctttt ggaagctggg caggtggcca cgcctgtaat cccagcattt tgggagtctg 4261 aggcaggtgg atcacttgag gccaggagtt caagactagc ctagccaaaa tgcaaaaccc 4321 tgtctctact aaagatacaa aaattagccg gatgcgatgg cacatgcctg taatctcagc 4381 tactcgggag gctgaggtag aagaatcgct tgaaccgggg aggcagaggt tgcagtgagc 4441 aagatggcgc cactgcactc cagcctgggt gacagaggga gactccatct caaaaaaaaa 4501 aaaaaaaaaa aagataaaaa ggaaacctaa gtactcttgg gctttgttaa ggattttgtt 4561 aaatatacaa aggattgcag ggaaaattaa cttattttta atattgagta tgcttatcca 4621 agagcaaaat aatatttctc catttattca aatcatttag gagcatcata gttttaacat 4681 atgggccttg cacgtatctt aaatttatct ctaggcattt taggttgttc agttgttctt 4741 gtgaatggga tctttttctc caaataggat tattgttgat atctgttgat tatgttaact 4801 ttgtagtttc tgactttact gaactgtctt cttagatcta atactctttt caatttcatc 4861 atatatttct cattcctatt ttgtttgggg tttttagggc gggaatatta acgggataag 4921 agagacaaaa gaaaatctgg aaaaacaatt cattttacct tacattgctt gtgattacta 4981 ccacactatt actgggttgg aaaaaattgt gaaatcccaa ggtgcctaat aaatgggagg 5041 tacctaagtg ttcatttaat gaattgtaat gattattgga atttctcttt cagtgagaag 5101 ctcttcatgg agatggcaga gctcatggtc tcagaaggct ggaaggatgc aggttatgag 5161 tacctctgca ttgatgactg ttggatggct ccccaaagag attcagaagg cagacttcag 5221 gcagaccctc agcgctttcc tcatgggatt cgccagctag ctaattatgt gagtttatag 5281 ataatgttct tgttcattca gaggactgta agcacttctg tacagaagct tgtttagaaa 5341 cagccctcat ggccgggcgt ggtggctcac gctgtaatcc caacactttg ggaggccgag 5401 gcgggtggat cacctgaggt caagagttca agaccagcct ggccaacatg gtgaaacccc 5461 aactctatta aaagtacaaa aaattagctg ggcatggtgg tgaacgcctg taaccccagc 5521 tacttgggag gctgaggcag gagaatcgct tgaacccagg aggtggaagt ttcagtgagc 5581 tgagatcacg ccattgcact ctagcctggg caacaaaaga gaaactccat ctcaaaaaaa 5641 aaaacaagga aaaaaagaaa cagccctcat gacacttaga aagtagaata gctggctgtt 5701 atctgaacat tgaattgtaa ggcttatcag gtggactttg cattccatca gcagacaatt 5761 tttttttttt tttttttttg agatggagtc tcattctgtc tcccaggctg gagggcagtg 5821 gtgcgatctc ggctcactgc aagctccacc tcctgggttc atgccattct cctgcctcag 5881 cctcccaagt agctgggacc acaggcaccc gccaccatgc ccagttaatt ttttgtattt 5941 ttagtagaga cggggtttca ccatgttagc caagatggtc tcgatctcct gacctcgtga 6001 tccgcccacc tcggcctccc aaagtgctgg gattacaggc atgagccacc gcgcctagcc 6061 tacaaatgtt ttgtaatagc tcttgaggcc catcttggag ttctcctttt gctaaaacca 6121 ctgaactctc taggaggaaa aaggaacttg gttcttgaca tatgtgtgca tgtatttcca 6181 tataaccttt aggaagctat tgcaatggta ctataaacta gaattttaga agatagaagg 6241 aaaatattct ggagatcatt gaagagaaat ggagtccaac actagttaaa gatgatgaag 6301 acagattttt ttttttgacg gagtctcgct ctgtcgccca ggctggagtg cagtggcaca 6361 atctcagctc actgcaaccc tccacctctt gggttcaagt gattctcctg cctcagcctc 6421 ccaagtagct gggactacag gcgcacacca ccacgcccgg ctaatttttg tatttttagt 6481 agagacaagg tttcaccata ttcgccaggc tggtctcgaa ctcctgacct tgtaatccgc 6541 ccaccttggc ctcccaaagt gctgggatta caggcatgag ccaccacgcc cggccgatga 6601 agacagattt tattcagtac taccacagta gaggaaagag ccaagttcaa ttccaaatac 6661 aacaaagaca ggtggagatt tatagccaat gagcagattg agggggtcag tggatggaat 6721 atttaagaag acatcaaggg tagggagctt cttgctaaag cttcatgtac ttaaacaaga 6781 agggtggggg atgagggaaa ttgatcagat atcaatggtg gcagtattga cttagcagga 6841 ttcttgctaa gaggtcttgc taggacagac ataggaagcc aaggtggagg tctagtcgaa 6901 aagaaggctc atcagagaag tctaactaaa gtttggtcaa gaagagtctt tgtcaaggta 6961 aatctatcat ttccctcaaa aggtaatttt caggatccca tcaggaagat tagcatggct 7021 gctagctttc tcctcagttc tgggctatag ctcacatgcc tagtttgaac tagctcagca 7081 gaactggggg atttattctt tgtcttccaa caaactcatc tggatgattt tgggggtttg 7141 tggggaaaag cccccaatac ctggtgaagt aaccttgtct cttcccccag cctggaatgg 7201 ttctctcttt ctgctacctc acgattgtgc ttctacaatg gtgactcttt tcctccctct 7261 catttcaggt tcacagcaaa ggactgaagc tagggattta tgcagatgtt ggaaataaaa 7321 cctgcgcagg cttccctggg agttttggat actacgacat tgatgcccag acctttgctg 7381 actggggagt agatctgcta aaatttgatg gttgttactg tgacagtttg gaaaatttgg 7441 cagatggtaa tgtttcattc cagagattta gccacaaagg aaagaacttt gaggccatgg 7501 tagctgagcc aaagaaccaa tcttcagaat tttaaatacc ctgtcacaat actggaaata 7561 attattctcc atgtgccaga gctcccatct cttctctttc agttcattaa ttaattaatt 7621 aattcatgta aaatccatgc atacctaacc atagctaata ttgtgcactt ataattcaag 7681 agggctctaa gagttaatta gtaattgtaa ctctctataa catcatttag gggagtccag 7741 gttgtcaatc ggtcacagag aaagaagcat cttcattcct gcctttcctc aatatacaca 7801 ccatctctgc actacttcct cagaacaatc ccagcagtct gggaggtact ttacacaatt 7861 taagcacaga gcaactgcct gtccctgctg ctagtttaaa catgaacctt ccaggtagcc 7921 tcttcttaaa atatacagcc ccagctgggc atgatggctc atgcctgtaa tcctagcact 7981 ttgggaggct gaggcgggtg gattacttga ggtcaggagt tcgagaccac cctggccaac 8041 atggtgaaac cccatctcta gtaaaaatac aaaaattagc tgactttggt ggcacatgcc 8101 tgtaatccca gctacttggg aagctgagac agaagagtca cttgaacctg ggaaacagag 8161 gttgcagtga gccaagatcg caccactgca ctccaccctg gatgacagac tgaaccccat 8221 ctcaaaaaat taaaataaaa taaaataaaa taactatata tatagcccca gctggaaatt 8281 catttctttc ccttatttta cccattgttt tctcatacag gttataagca catgtccttg 8341 gccctgaata ggactggcag aagcattgtg tactcctgtg agtggcctct ttatatgtgg 8401 ccctttcaaa aggtgagata gtgagcccag aatccaatag aactgtactg atagatagaa 8461 cttgacaaca aaggaaacca aggtctcctt caaagtccaa cgttacttac tatcatccta 8521 ccatctctcc caggttccaa ccacttctca ccatccccac tgctgtaatt atagcctaag 8581 ctaccatcac ctggaaagtc atccttgtgt cttccccttt atttcaccat tcatgtcctg 8641 tctatcaaca gtccttccac cagtatctct aaaatatctc ctgaatcagc ccacttcctt 8701 ccatcttcac tacatgcacc ctggccttcc aagctactat cggctctcaa ccagactgct 8761 gggaccacct gatctctctg cttccactct gtctcaaccc ccatctattt tccaagcagc 8821 actagagtta tcatattaaa atgtaaatat cagttttttt tttaaagaaa aaaaccctga 8881 gacttaacag agttataaaa aatataaatg tcatcatcag ttccctgctt aaaaccctta 8941 actcgcttcc aattgcactt ggaatgaaac caaactgcac tgatccagcc cttgcctgcc 9001 tccccaaagt ccaaggggtc atggctcttt ccctggctac actggttttc tttctgtccc 9061 tcaacactgc aagcctattg ctgccccagg gcctttacac ttgctttttt tctgcctaga 9121 acagttcttc cccaaagatt tttaaagggc cgggctcctt aacattgaag tcgcagacca 9181 aacgccacat atgcagacag ttcttctcta actactttaa aatagccctc tgtccattca 9241 ttcttcatca cattaacctg tttaattttc ttctcagagc tccacactat ttggaagtat 9301 ttgttgactt gttaccatgt ctccccacta gagtgtaagt ttcatgaggg cagggacctt 9361 gtctgacttt gactgtatct ctcgcatatg gttaagtgtt aaatagttat ttatggaatg 9421 aatccctatt attccctcat tatctctgca aaatagtctt ttttctcaac atcttaaacc 9481 tgatatccca cctgcctatc tacaaacttt ttttttgcga cagagtctca ctgtcaccca 9541 ggctagagtg cagtggcgcc atctcggctc actgcaacct ccgcctcccg ggtttaagcg 9601 attctcttgc ctcagcctcc cagtagctgg gattataggc gtgcgctacc acatctggct 9661 aatttttgta tttttagtag agatggtttc accatgttgg ccaggcttgt ctcgaactcc 9721 tgacctcaga tgatccacct gcctcggcct cccaaagtgc tgggattaca ggcatgagcc 9781 accgtgccca gcctctacaa actttttatt ccattaacaa actatatgct gggatttaag 9841 ttttcttaat acttgatgga gtcctatgta attttcgagc ttttaatttt actaagacca 9901 ttttagttct gattatagaa gtaaattaac tttaagggat ttcaagttat atggcctact 9961 tctgaagcaa acttcttaca gtgaaaattc attataaggg tttagacctc cttatggaga 10021 cgttcaatct gtaaactcaa gagaaggcta caagtgcctc ctttaaactg ttttcatctc 10081 acaaggatgt tagtagaaag taaacagaag agtcatatct gttttcacag cccaattata 10141 cagaaatccg acagtactgc aatcactggc gaaattttgc tgacattgat gattcctgga 10201 aaagtataaa gagtatcttg gactggacat cttttaacca ggagagaatt gttgatgttg 10261 ctggaccagg gggttggaat gacccagata tggtaaaaac ttgagccctc cttgttcaag 10321 accctgcggt aggcttgttt cctattttga cattcaaggt aaatacaggt aaagttcctg 10381 ggaggaggct ttatgtgaga gtacttagag caggatgctg tggaaagtgg tttctccata 10441 tgggtcatct aggtaacttt aagaatgttt cctcctctct tgtttgaatt atttcattct 10501 ttttctcagt tagtgattgg caactttggc ctcagctgga atcagcaagt aactcagatg 10561 gccctctggg ctatcatggc tgctccttta ttcatgtcta atgacctccg acacatcagc 10621 cctcaagcca aagctctcct tcaggataag gacgtaattg ccatcaatca ggaccccttg 10681 ggcaagcaag ggtaccagct tagacaggta aataagagta tatattttaa gatggcttta 10741 tatacccaat accaactttg tcttgggcct aaatctattt ttttcccttg ctcttgatgt 10801 tactatcagt aataaagctt cttgctagaa acattacttt atttccaaaa taatgctaca 10861 ggatcatttt aatttttcct acaagtgctt gatagttctg acattaagaa tgaatgccaa 10921 actaacaggg ccacttatca ctagttgcta agcaaccaca ctttcttggt ttttcaggga 10981 gacaactttg aagtgtggga acgacctctc tcaggcttag cctgggctgt agctatgata 11041 aaccggcagg agattggtgg acctcgctct tataccatcg cagttgcttc cctgggtaaa 11101 ggagtggcct gtaatcctgc ctgcttcatc acacagctcc tccctgtgaa aaggaagcta 11161 gggttctatg aatggacttc aaggttaaga agtcacataa atcccacagg cactgttttg 11221 cttcagctag aaaatacaat gcagatgtca ttaaaagact tactttaaaa tgtttatttt 11281 attgccaact actacttcct gtccaccttt ttctccattc actttaaaag ctcaaggcta 11341 ggtggctcat gcctgtaatc ccagcacttt gggaggctga ggcgggcaga tcacctgagg 11401 tcgggacttt gagacccgcc tggacaacat ggtgaaaccc catttctaat aaaaatataa 11461 aaattagcca ggtgtggtgg cgcacctgtg gtcccagcta ctctgggggc tgaggcatga 11521 gaatcgcttg aacccgggag tggaggttgc attgagctga gatcatgcca cctcactcca 11581 gcctgggcaa caaagattcc atctcaaaaa aaaaaaaaaa gccaggcaca gtggctcatg 11641 cctggaatcc cagcactttt ggaagctgag gcaggcagat cacttgaggt taggatttca 11701 agaccagcct ggctaacata gtaaagccct gtctctacta aaaatacaaa aattagccag 11761 gtatggtggc gagcttctgt agccccagct actcaggaga ctgaggcagg agaatcactt 11821 gaacccggga agtggggggg tgcagtgacc caagatcacg ccactgcatt ccagcctggg 11881 caacagagca agactccatc tcaaaaaaaa aagttctatt tccttgaata aaattttccg 11941 aagtttaaac tttaggaata aaactattaa acccgtattt actcatccag atacccaccc 12001 cccttgttga gattctctcc caattatcaa aatgtgtagc atatttaact accaagagct 12061 aaacatcatt aagactgaaa tgtattaaga aggatgtata ggccaggcac ggtgtctcac 12121 gcctgtaatc ccaacacttt gggaggccaa gtcgggcgga tcacgaggtc aggagatgga 12181 gaccatcctg gccaacatgg tgaaaccccc tctctactaa aaatacaaaa attagccagg 12241 caggtggcag gcacctgtaa tcccagctac tccagaggct gaggcaggac aatcacttga 12301 acctgggagg cagaggctgc agtgagctga ggttgtacca attgcactcc agcctaggta 12361 acgagcaaca ctccatctca aaaaaagaaa aaaaaaaaga tgtataattt ggaactgtta 12421 agaggcattt taaaga //