LOCUS       HSGLTH1      1020 bp    DNA             PRI       26-JAN-1995
DEFINITION  Human theta 1-globin gene.
ACCESSION   X06482
NID         g31775
KEYWORDS    globin; theta-1-globin; theta-globin.
SOURCE      human.
  ORGANISM  Homo sapiens
            Eukaryotae; mitochondrial eukaryotes; Metazoa; Chordata;
            Vertebrata; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1020)
  AUTHORS   Hsu,S.L., Marks,J., Shaw,J.P., Tam,M., Higgs,D.R., Shen,C.C. and
            Shen,C.K.
  TITLE     Structure and expression of the human theta 1 globin gene
  JOURNAL   Nature 331 (6151), 94-96 (1988)
  MEDLINE   88122547
COMMENT     Data kindly reviewed (20-Jan-1989) by Shen C.K.J.
FEATURES             Location/Qualifiers
     source          1..1020
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /clone="cosmid Calpha3'Bg"
     promoter        23..27
                     /note="CAAT-Box"
     promoter        57..61
                     /note="TATA-Box"
     precursor_RNA   128..972
                     /note="put. transcript (K562 cells); maj."
     mRNA            128..375
                     /note="put. Exon 1"
     misc_feature    177..182
                     /note="GGGCGG-Box"
     misc_feature    190
                     /note="alternate pot. transcription initiation site; min."
     misc_feature    242
                     /note="alt. pot. transcription initiation site; min."
     CDS             join(281..375,460..664,774..902)
                     /codon_start=1
                     /product="theta 1-globin"
                     /db_xref="PID:g31776"
                     /db_xref="SWISS-PROT:P09105"
                     /translation="MALSAEDRALVRALWKKLGSNVGVYTTEALERTFLAFPATKTYF
                     SHLDLSPGSSQVRAHGQKVADALSLAVERLDDLPHALSALSHLHACQLRVDPASFQLL
                     GHCLLVTLARHYPGDFSPALQASLDKFLSHVISALVSEYR"
     intron          376..459
                     /note="Intron I"
     mRNA            460..664
                     /note="Exon 2"
     intron          665..773
                     /note="Intron II"
     mRNA            774..972
                     /note="Exon 3"
     misc_feature    952..957
                     /note="put. polyA signal"
     polyA_site      972
                     /note="put. polyA site"
BASE COUNT      146 a    362 c    357 g    155 t
ORIGIN      
        1 ccactgcact caccgcaccc ggccaatttt tgtgttttta gtagagacta aataccatat
       61 agtgaacacc taagacgggg ggccttggat ccagggcgat tcagagggcc ccggtcggag
      121 ctgtcggaga ttgagcgcgc gcggtcccgg gatctccgac gaggccctgg acccccgggc
      181 ggcgaagctg cggcgcggcg ccccctggag gccgcgggac ccctggccgg tccgcgcagg
      241 cgcagcgggg tcgcagggcg cggcgggttc cagcgcgggg atggcgctgt ccgcggagga
      301 ccgggcgctg gtgcgcgccc tgtggaagaa gctgggcagc aacgtcggcg tctacacgac
      361 agaggccctg gaaaggtgcg gcaggctggg cgcccccgcc cccaggggcc ctccctcccc
      421 aagccccccg gacgcgcctc acccacgttc ctctcgcagg accttcctgg ctttccccgc
      481 cacgaagacc tacttctccc acctggacct gagccccggc tcctcacaag tcagagccca
      541 cggccagaag gtggcggacg cgctgagcct cgccgtggag cgcctggacg acctacccca
      601 cgcgctgtcc gcgctgagcc acctgcacgc gtgccagctg cgagtggacc cggccagctt
      661 ccaggtgagc ggctgccgtg ctgggcccct gtccccggga gggccccggc ggggtgggtg
      721 cggggggcgt gcggggcggg tgcaggcgag tgagccttga gcgctcgccg cagctcctgg
      781 gccactgcct gctggtaacc ctcgcccggc actaccccgg agacttcagc cccgcgctgc
      841 aggcgtcgct ggacaagttc ctgagccacg ttatctcggc gctggtttcc gagtaccgct
      901 gaactgtggg tgggtggccg cgggatcccc aggcgacctt ccccgtgttt gagtaaagcc
      961 tctcccagga gcagccttct tgccgtgctc tctcgaggtc aggacgcgag aggaaggcgc
//