LOCUS HSHLADMBG 6933 bp DNA PRI 25-JUN-1997 DEFINITION H.sapiens HLA-DMB gene. ACCESSION X76776 NID g512471 KEYWORDS HLA-DMB gene. SOURCE human. ORGANISM Homo sapiens Eukaryotae; mitochondrial eukaryotes; Metazoa; Chordata; Vertebrata; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 6933) AUTHORS Radley,E., Alderton,R.P., Kelly,A., Trowsdale,J. and Beck,S. TITLE Genomic organization of HLA-DMA and HLA-DMB. Comparison of the gene organization of all six class II families in the human major histocompatibility complex JOURNAL J. Biol. Chem. 269 (29), 18834-18838 (1994) MEDLINE 94308138 REFERENCE 2 (bases 1 to 6933) AUTHORS Beck,S. TITLE Direct Submission JOURNAL Submitted (16-DEC-1993) S. Beck, Imperial Cancer Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, UK FEATURES Location/Qualifiers source 1..6933 /organism="Homo sapiens" /db_xref="taxon:9606" /clone="cosmid HA14" /chromosome="6" /map="p21.3" promoter 19..28 /note="NFkB" promoter 73..82 /note="J-box" promoter 119..128 /note="J-box" promoter 134..147 /note="Sp1" promoter 313..322 /note="J-box" promoter 439..448 /note="J-box" promoter 440..458 /note="X-box" promoter 478..487 /note="Y-box" CAAT_signal 513..517 promoter 574..588 /note="Sp1" promoter 582..591 /note="NFkB" promoter 740..749 /note="J-box" gene 756..6592 /gene="HLA-DMB" CDS join(756..810,2598..2879,4107..4391,5911..6027,6186..6221, 6576..6592) /gene="HLA-DMB" /codon_start=1 /db_xref="PID:g512472" /db_xref="SWISS-PROT:P28068" /translation="MITFLPLLLGLSLGCTGAGGFVAHVESTCLLDDAGTPKDFTYCI SFNKDLLTCWDPEENKMAPCEFGVLNSLANVLSQHLNQKDTLMQRLRNGLQNCATHTQ PFWGSLTNRTRPPSVQVAKTTPFNTREPVMLACYVWGFYPAEVTITWRKNGKLVMPHS SAHKTAQPNGDWTYQTLSHLALTPSYGDTYTCVVEHIGAPEPILRDWTPGLSPMQTLK VSVSAVTLGLGLIIFSLGVISWRRAGHSSYTPLPGSNYSEGWHIS" exon 756..810 /gene="HLA-DMB" /number=1 /evidence=experimental intron 811..2597 /gene="HLA-DMB" /number=1 promoter 829..838 /gene="HLA-DMB" /note="NFkB" repeat_region 1564..1814 /rpt_family="MER21" repeat_region complement(1899..2025) /rpt_family="MER21" exon 2598..2879 /gene="HLA-DMB" /number=2 /evidence=experimental intron 2880..4106 /gene="HLA-DMB" /number=2 exon 4107..4391 /gene="HLA-DMB" /number=3 /evidence=experimental intron 4392..5910 /gene="HLA-DMB" /number=3 exon 5911..6027 /gene="HLA-DMB" /number=4 /evidence=experimental intron 6028..6185 /gene="HLA-DMB" /number=4 exon 6186..6221 /gene="HLA-DMB" /number=5 /evidence=experimental intron 6222..6575 /gene="HLA-DMB" /number=5 exon 6576..6915 /number=6 /evidence=experimental polyA_signal 6910..6915 BASE COUNT 1858 a 1423 c 1717 g 1935 t ORIGIN 1 acaatggagg cccatggagg gattttccag gcccctattc ctgatctcca tggtggcgct 61 gcttccctta ttctgcagtc ttgctttgag accagacaat tctgtactct gtctgtgcct 121 tcttccttct cagcagccct gcctctgcca cctgccccag aagggctctg ggtcctctca 181 tctcaggaca gacaagggtt tttgtaatta tcttcttggg taacctccct gtaaggaata 241 ggagaggtta tctggtcctg gtcttttggg agagcattga gaagaaaaag ttaaaccagt 301 gggcagccca ggctgcatac atcctgggaa tattgcgatt attctctcca gtaatctacg 361 gaaatctact ggttgttctg cagaaaaaga attaagagag acaaggagac ctgttgtcta 421 agactaaggc aggatgacgt ttacctagta actgatgatg ctaggctgag gcactcagtg 481 atttgtctct acatttgtcc ctgcctacct agccaatctg tccctgtttg ggacactgga 541 ctcccgtgag ctggaaggaa cagatttaat atctaggggc tgggtatccc cacatcactc 601 atttgggggg tcaagggacc cgggcaatat agtattctgc tcagtgtctg gagatcatct 661 acccaggctg gggcttctgg gacaggcgag gacccacgga ccctggaaga gctggtccag 721 gggactgaac tcccggcatc tttacagagc agagcatgat cacattcctg ccgctgctgc 781 tggggctcag cctgggctgc acaggagcag gtaaggacac ttcttctggg gactctccct 841 tcccctgctc ctgtttcagg gtaagggtgt tccgttttgt aattgcattt gacaccccag 901 atagtttgtc tccctggtat acattcctat agcactttgt actttgtagc aattttaatg 961 taattaatct gtataattat ctgtgcagtg tatattccct gctggaatat aggcaaggac 1021 aatgttcatc ttatttattg ctgcctcctc agctcctagc acagtgcctt gcatgcagca 1081 agtgcttcat aaatatgtgc gaagtgaata tttaatattt ccagcacaat acaaggctga 1141 ctctttctct tgaccctttt tctctctcaa taatttgcct tactgaaggt ctgtgttctg 1201 ggcaaattgt catgtttaaa catgcaaata atctcggggg gctactccta tccctgtgct 1261 tagtcttgca taaagaggag actggatcta aaaacttatc tactacttct actgactccc 1321 tcaaatcaga ctttcagaaa cttcagtgta tgagcttggt cagtagatgt tccctgagca 1381 ggaaatctgt gccagactag ctggatgtca ccaaggctta ggttctgagc tgaatatagg 1441 aaaaatcaac tttttttctt ctatatgctc acactcaaca cttctttgac caactgtgtg 1501 aggttttttt ttttttttta ctcataccaa ccaattctcc tatattagct ggatatccta 1561 taattcaatt ccattgtgac attaactaga gttaacatag acaccaaagg ttaaagactc 1621 agtcccataa gactgcctcc atttcagaca ccaatcacaa gtagtaggtt cccaaattac 1681 ccacatcttc tgtccaactt gcctacaaat cagaggttcc catgaccccc tccttggggt 1741 tggtaatttg ctaaagtggc ttatggaact caggaaaagt ttacttatta ttgtagattt 1801 tttacaaagg atattttaat tgataataat aattataaat attcatgggg tggataatga 1861 tgttttagta catgtaatgt acagtgatca gatcagatca tcatctcatt tatcatttct 1921 ttgtgttgga aacattccat atccttcttc tagcgatttg aaatgatata aagtattatt 1981 gttaatgaca gtcatcccac agtggtatag aacactagat cataattttg catcctttaa 2041 caaaggatat tttaaagcat acaaaggaac atccagatga agagatacca gatctggaag 2101 ggtcccaatc acaggagctc tgtccccaca gaattggggt acttcacctc ctggcatgtg 2161 gatgtgttta ccaactgaga agttctctga actccatagt tccgggattt ttatggaggc 2221 ttcatcatgt aggcatgact gattattaac tcaatctcca gccccttccc cttcagggag 2281 tatgggggat gggactaaaa gttccagact tctaatcatg acttggtctt tctggtgacc 2341 agcccctcct gcaggagccc accaagagta cctcattaga acaaaagaca ctcctgttat 2401 ctaggaaatt ctaagcgatt aggcactcta tgtcaggaac cagggtcaaa gacaaagctc 2461 tgtgcagagc tcctaaatat acgtctgtat gttttatata tttattattt gtgtatattt 2521 attatttata tatttattta tttattgcca ggccagtaga agacattgac ctgttctccc 2581 ttccctggct cctctaggtg gcttcgtggc ccatgtggaa agcacctgtc tgttggatga 2641 tgctgggact ccaaaggatt tcacatactg catctccttc aacaaggatc tgctgacctg 2701 ctgggatcca gaggagaata agatggcccc ttgcgaattt ggggtgctga atagcttggc 2761 gaatgtcctc tcacagcacc tcaaccaaaa agacaccctg atgcagcgct tgcgcaatgg 2821 gcttcagaat tgtgccacac acacccagcc cttctgggga tcactgacca acaggacacg 2881 tgaggagaga ggggtgcaga ggggctacca ggaagtgcag ttaggagggc aggccaggga 2941 ggatcccaca gtggcccagg ggtttgagat ttgagcagca aataagagaa aatgtgtgga 3001 tctgaaatgt agaaagacgg aggattgaac ctcaagggga acaaggtggc tgacgtgagt 3061 ggaacaggag taaagaaggg gaggtgaggc ttgaaccgcg aggtgccatg tggggagctt 3121 atgcagaggc tggggcatct caggatgcat acccaagatg ttcttgcctt gttatcccag 3181 attttgatgt tccagatctg atgtgggccc aggcatggga atatttggaa tcccagggga 3241 ttctgacaca tgctttttct cacccttaaa ctcttgcatt gacaatggct tgaagtttgt 3301 gaaagtaaac ttgaagatct ccacagtaca gaacagtgtg tctcaagggt ggtttctgaa 3361 ccacctttct cagaattgcc tggaggaggt gcttgttaaa gatgcaagcc ccttagtacc 3421 actccagatc tgttgaaaga aagtatctgg ggatacagcc taggaaatct gcattttaac 3481 ataattcctt ggatttttat ttaagattgt gtttgaaaaa tgtcaagata gaggcaagca 3541 agaggatcac ctaggagagt aaattagtaa aagatggcag tattagcaat ctctttagtt 3601 tgactacatt cattccaaat ttaagagtga gtcctaagtt aggcttgttt ccttgaacta 3661 tgtgaggaga aaaagcttta actagcaaaa gaacgtatta aacaagattt ggagaaaaat 3721 tccttttcca ccttaaaaaa acccaatgta caactctgga ttactcttag cttccttatt 3781 tcaaatactt tccagtttat gtacttgaaa taaatacaac aacttctaga acagcttgca 3841 gttcagatct ggcttttact aattgtaatc aaacataatt ctggaggagg aaagaaagaa 3901 aggggcaatg aaggaatggg agagaagaaa gagtaatgca ggaatacatt ctaacggttc 3961 cccttcaagg ggcagcatgg cagagggggc tggggtggaa agtgggttgc aaaatctacg 4021 aagagttgcg atagggaaga aaccaggttg aggaagcagc cagaatgtca ccctccttcc 4081 taaacatgtt tttttctcct atgcagggcc accatctgtg caagtagcca aaaccactcc 4141 ttttaacacg agggagcctg tgatgctggc ctgctatgtg tggggcttct atccagcaga 4201 agtgactatc acgtggagga agaacgggaa gcttgtcatg cctcacagca gtgcgcacaa 4261 gactgcccag cccaatggag actggacata ccagaccctc tcccatttag ccttaacccc 4321 ctcttacggg gacacttaca cctgtgtggt agagcacatt ggggctcctg agcccatcct 4381 tcgggactgg agtaagtgta tggcagatgg atggaattag ggtcaaagca gagaaaatga 4441 gatgtggatc gatacatggt acatggtaga cagcgaagtg ctgaaaatgg ggactgagtc 4501 tggaggaact tacggggggc ttaggaccag aatggggaaa tgggataaag aaatggaaat 4561 atttaggttg gtgcaaaagt aattgcagtt tttgccatta ctttcagtgg caaaaaccgc 4621 aattactttt gcaccagttt aatatttagt ctgtgctatt gctgctctgg tggtgtggtt 4681 gatgttgctg cgtctatgtt tgagggtgag aggggagcgt gcttgctttg aaatgaggat 4741 gtaaatttgg caatcatatt ttcagaaccc caaattgtaa tacactattc tagcctcctt 4801 agatttcaac tattctggtg ccagaagcag atgggagctg aaggaatgat gaaggttgaa 4861 gaaggggggc ttttcttggt gtggggcagt actgcatttg gcctgctcta ccaagcatac 4921 gggagtagta aagccacggc tggcagacca tttggcatgc atgctcaggg gccagtggat 4981 aaagaattac ttacagttca aacactgttt gaactcagtg tcgggagtag ttaaaggtat 5041 cgtgagaagt tgcacacagc tttggggact cttggaaaag aaagaggaag aaatgaggaa 5101 gaggaagggt gtctacaaag ggccagagaa caggatctca gatcagctgc tgtaaccagg 5161 tttccccttg tgggaagtgt tgtttcttgc tgggcagttg ggaagggaat ggagaacaga 5221 gaagagagtg gaaatcacat gctcacttga actttcctgg ggaacgtctc ctcacagcgt 5281 gcacaagagc ctccctttag aaatggagtg ttcattttat catgggaaaa gaatctgagt 5341 gggacatgat tcagaacagg accggcccaa ggaagtgcag gggctgtgga gtgggatgga 5401 gacaagctct gaaaggacac atgggagatc tagatgtaga aggtacacaa gtagtaggat 5461 aactcacagg atggatccac tggaggttaa gacatgtggt aagacagtgt aataggaagc 5521 tgctcagttg gagaaagtaa ggaagcaaac attgttaccg tgggggcaat ggagaggaca 5581 gtgaggagcc ctttatcctg ataagggtgg ctttgaggta aaggaaggaa agaggatgcc 5641 ttgagaggcc ccactgtatt agagaggacc tggaagccag gatgctaatt ctggggagat 5701 ggattcccca ggcttactct aggagtagag gtccatggga cgagggtttg atttgagaaa 5761 gatcattttc ttgggagtgg gtggtgtgag ctagaccctt ggagctggga taaaggacct 5821 tttaacccac tgagaggtgg ctgcaataaa tggaattgcc ctgggggtga gcaacagaaa 5881 ctgggtcaag taagtttcta ttttttgcag cacctgggct gtcccccatg cagaccctga 5941 aggtttctgt gtctgcagtg actctgggcc tgggcctcat catcttctct cttggtgtga 6001 tcagctggcg gagagctggc cactctagtg agtgactcgc tgaactccca tccccactct 6061 tggtcccact ctctgcttac tttctgtttg tgattaactc tctccttcct actgcatttg 6121 ctatgaatac tgctagatat tttcatccac aaagactggt ataatcaagt atcttcctct 6181 cttaggttac actcctcttc ctgggtccaa ttattcagaa ggtaacatct ctgttggtct 6241 gtttccctac ttgccctttg gtaggggtgc gggttagagg ggtcagtgtt gggttcaact 6301 aatcttgatt attatatggg tgagcttcca tgaggatcta ggcaagggca tgatttaagc 6361 tgccattgct aggattaaga gcaggaagga gcatcctcct cttctaccaa gtgggatgtc 6421 tgtggagagg aggctgaagg tgcttccttt gtattagttg ttggtgccct ggagttttca 6481 gtatcactgt attaaggcat gggatggtta cagtgacaaa cgatgggggc aagttgggtt 6541 gaagcctcat tatctccctt ttatttattc tgtaggatgg cacatttcct agaggcagaa 6601 tcctacaact tccactccaa gtgagaagga gattcaaact caatgatgct accatgcctc 6661 tccaacatct tcaaccccct gacattatct tggatcctat ggtttctcca tccaattctt 6721 tgaatttccc agtctcccct atgtaaaact tagcaacttg ggggacctca ttcctgggac 6781 tatgctgtaa ccaaattatt gtccaaggct atatttctgg gatgaatata atctgaggaa 6841 gggagttaaa gaccctcctg gggctctcag tgtgccatag aggacagcaa ctggtgattg 6901 tttcagagaa ataaactttg gtggaaatat tgt //