LOCUS HSHSC70 5408 bp DNA PRI 09-MAY-1995 DEFINITION Human hsc70 gene for 71 kd heat shock cognate protein. ACCESSION Y00371 NID g32466 KEYWORDS heat shock cognate protein; hsc70 gene. SOURCE human. ORGANISM Homo sapiens Eukaryotae; mitochondrial eukaryotes; Metazoa; Chordata; Vertebrata; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 5408) AUTHORS Dworniczak,B. and Mirault,M.E. TITLE Structure and expression of a human gene coding for a 71 kd heat shock 'cognate' protein JOURNAL Nucleic Acids Res. 15 (13), 5181-5197 (1987) MEDLINE 87259994 REFERENCE 2 (bases 1 to 5408) AUTHORS Rensing,S.A. and Maier,U.G. TITLE Phylogenetic analysis of the stress-70 protein family JOURNAL J. Mol. Evol. 39 (1), 80-86 (1994) MEDLINE 94343547 FEATURES Location/Qualifiers source 1..5408 /organism="Homo sapiens" /db_xref="taxon:9606" /clone="phage521" /clone_lib="human liver DNA in lambda L47.1" misc_feature 4..17 /note="heat shock consensus element" misc_feature 109..113 /note="regulatory sequence" misc_feature 178..191 /note="heat shock consensus element" TATA_signal 199..203 mRNA join(227..304,1035..1244,1567..1772,2097..2249,2337..2892, 3104..3306,3535..3733,3881..4113,4445..>4630) exon 227..304 /number=1 prim_transcript 227..>4630 intron 305..1034 /number=1 exon 1035..1244 /number=2 CDS join(1040..1244,1567..1772,2097..2249,2337..2892, 3104..3306,3535..3733,3881..4113,4445..4630) /codon_start=1 /product="71 Kd heat shock cognate protein" /db_xref="PID:g32467" /db_xref="SWISS-PROT:P11142" /translation="MSKGPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAF TDTERLIGDAAKNQVAMNPTNTVFDAKRLIGRRFDDAVVQSDMKHWPFMVVNDAGRPK VQVEYKGETKSFYPEEVSSMVLTKMKEIAEAYLGKTVTNAVVTVPAYFNDSQRQATKD AGTIAGLNVLRIINEPTAAAIAYGLDKKVGAERNVLIFDLGGGTFDVSILTIEDGIFE VKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDISENKRAVRRLRTACERAKRTLSS STQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAKLDKSQIHDI VLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQDLL LLDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMT KDNNLLGKFELTGIPPAPRGVPQIEVTFDIDANGILNVSAVDKSTGKENKITITNDKG RLSKEDIERMVQEAEKYKAEDEKQRDKVSSKNSLESYAFNMKATVEDEKLQGKINDED KQKILDKCNEIINWLDKNQTAEKEEFEHQQKELEKVCNPIITKLYQSAGGMPGGMPGG FPGGGAPPSGGASSGPTIEEVD" intron 1245..1566 /number=2 exon 1567..1772 /number=3 intron 1773..2096 /number=3 exon 2097..2249 /number=4 intron 2250..2336 /number=4 exon 2337..2892 /number=5 intron 2893..3103 /number=5 exon 3104..3306 /number=6 intron 3307..3534 /number=6 exon 3535..3733 /number=7 intron 3734..3880 /number=7 exon 3881..4113 /number=8 intron 4114..4444 /number=8 exon 4445..>4630 /number=9 polyA_signal 4843..4848 BASE COUNT 1411 a 1079 c 1420 g 1498 t ORIGIN 1 gagcttgaaa gttccagaac gctgcggtga gtgcgttatc gtgaggcggc gcggtggggt 61 gggtgcggaa gggggcgagg cgaggagtgg agccgcgttg tgattgtgat tgggtcttgt 121 aagggcagcc ggactctatt ggccgggaac ctaatgcagg aagcaggcgg accccttctg 181 gaaggttcta agatagggta taagaggcag ggtggcgggc ggaaaccggt gctcagttga 241 actgcgctgc agctcttggt tttttgtggc ttccttcgtt attggagcca ggcctacacc 301 ccaggtaaaa cctctgctca agagttgggt tgtgggtctg ggagcgtgca gcctccacac 361 aggcctgttg ggcttgctga ggcttggggg ttctgagaat ctcgtcgagg cgagtgtgcg 421 gctccttcta ccggcttaaa gggcctcagt tttcggtggg atggcagcgg tatttggttg 481 cagccggcag acggaaatgt agggagtggg ccgcatggcc ccaggggagg ctgggagacg 541 cccggccgcg tggcggggga gggttgctgc atcggtttgc ctggcgcgcg gggaagtgga 601 gccagcgttt tctttcaccc agttccctgc ttagtccagt cccaccgtgg ttcttcagag 661 ctgttcttgg cgtgcttcca gtatgggggt acattccgga gtagttaaaa gcccgttgac 721 tcccgggggg cactggcacc tggcgaggga ggggaacaga cagtgctcag ttcggggtaa 781 gaccacgtgt tgagcaacgc cccacgccgt ctgggtcgat gggtccttca tctagggcgt 841 gctgtgctgc ggttggcacg gcaacctgga ctgcagcact agttctggac ctcgcgcgtg 901 cttagacagg aggtgatggg cactattacc tcttggcagt ggccatacgt ttttcctggt 961 taagtgttct gttaagggat gagggaaata ttttgattaa ttgaattttt aaaccagatt 1021 tttctttttt tcagcaacca tgtccaaggg acctgcagtt ggtattgatc ttggcaccac 1081 ctactcttgt gtgggtgttt tccagcacgg aaaagtcgag ataattgcca atgatcaggg 1141 aaaccgaacc actccaagct atgtcgcctt tacggacact gaacggttga tcggtgatgc 1201 cgcaaagaat caagttgcaa tgaaccccac caacacagtt tttggtgagt tcctaatttt 1261 aaatgacaga acaaatataa acagggctag gaagcacaaa agtttatgaa acgtgaggag 1321 ggaacttttt gattttagaa aaactgagct gagagacttg ttatcaagtc tgttataaaa 1381 caggttgtag aaacctttca ggctgaaatc tggataacgt aggaggttga agtttgaacc 1441 tttgctaggt atatggtagt tgaattcacc tacctatgaa ctgttaggta tttgagtaat 1501 catggacttg agttttatct gaagagctat gaaattgaaa gtgttttcat ttgacacctt 1561 ttacagatgc caaacgtctg attggacgca gatttgatga tgctgttgtc cagtctgata 1621 tgaaacattg gccctttatg gtggtgaatg atgctggcag gcccaaggtc caagtagaat 1681 acaagggaga gaccaaaagc ttctatccag aggaggtgtc ttctatggtt ctgacaaaga 1741 tgaaggaaat tgcagaagcc taccttggga aggtgaggtt ggtttttcag tatggggtgc 1801 attccggagt agttaaaagc ccgatgactc ccgggggcac tggcacctgg cgagggaggg 1861 gaacagatgg ggctcagctc agggttaaga ccacgtgccc aacagtgccc taggctctct 1921 aggtagatgg gtctgtcaac accagaaacc agtgaatctt gacaattaca cagtaattta 1981 cattttggtg gggggggtgc tccagctgtt gtttcaccag cattaatcca tttgctggag 2041 tttgcatata tgtaagtata atagttacca atctgtggtc ttttccttat tcctagactg 2101 ttaccaatgc tgtggtcaca gtgccagctt actttaatga ctctcagcgt caggctacca 2161 aagatgctgg aactattgct ggtctcaatg tacttagaat tattaatgag ccaactgctg 2221 ctgctattgc ttacggctta gacaaaaagg tatgtaccat ttgtgatgca agttcggatt 2281 attttaagat taatttgatc catcgtaaat ttaaatgaga ttgtttttaa cggcaggttg 2341 gagcagaaag aaacgtgctc atctttgacc tgggaggtgg cacttttgat gtgtcaatcc 2401 tcactattga ggatggaatc tttgaggtca agtctacagc tggagacacc cacttgggtg 2461 gagaagattt tgacaaccga atggtcaacc attttattgc tgagtttaag cgcaagcata 2521 agaaggacat cagtgagaac aagagagctg taagacgcct ccgtactgct tgtgaacgtg 2581 ctaagcgtac cctctcttcc agcacccagg ccagtattga gatcgattct ctctatgaag 2641 gaatcgactt ctatacctcc attacccgtg cccgatttga agaactgaat gctgacctgt 2701 tccgtggcac cctggaccca gtagagaaag cccttcgaga tgccaaacta gacaagtcac 2761 agattcatga tattgtcctg gttggtggtt ctactcgtat ccccaagatt cagaagcttc 2821 tccaagactt cttcaatgga aaagaactga ataagagcat caaccctgat gaagctgttg 2881 cttatggtgc aggtaacaat ggtatctcaa ttaaccctaa aggcaggcag gcccaaggtg 2941 actcgctgtg atgagtgatt gttaaacatt cgtagtttcc accaaaagct tggctaatga 3001 tggcaacacc ttccttggat gtctgagcga gtgatagtta aaacaggagc tatgtactgg 3061 gttttctttt aacttctttt aacgttaact ttttgtttgc tagctgtcca ggcagccatc 3121 ttgtctggag acaagtctga gaatgttcaa gatttgctgc tcttggatgt cactcctctt 3181 tcccttggta ttgaaactgc tggtggagtc atgactgtcc tcatcaagcg taataccacc 3241 attcctacca agcagacaca gaccttcact acctattctg acaaccagcc tggtgtgctt 3301 attcaggtat gtttctgtac ttctcttgtt tggcttactg ataacagata aagggaagtc 3361 ttgactgact cgctatgatg atggattcca aaaccattcg tagtttccac cagaaagtct 3421 tatgttggcc agttccttcc ttggatgttt gagcgaccat tcttccttag caggacccta 3481 gcactgtcac agacctggag tccattgtag taatttgttt tatttcctac caaggtttat 3541 gaaggcgagc gtgccatgac aaaggataac aacctgcttg gcaagtttga actcacaggc 3601 atacctcctg caccccgagg tgttcctcag attgaagtca cttttgacat tgatgccaat 3661 ggtatactca atgtctctgc tgtggacaag agtacgggaa aagagaacaa gattactatc 3721 actaatgaca agggtaagga ggcactgtca tctggtcttg acagggataa tggtatttca 3781 attgagttac tggtgaataa gggcgtctag ctaagagaaa ctagagttac acatacacag 3841 gtaatttaag gcttttactt agagttaatt tctttcctag gccgtttgag caaggaagac 3901 attgaacgta tggtccagga agctgagaag tacaaagctg aagatgagaa gcagagggac 3961 aaggtgtcat ccaagaattc acttgagtcc tatgccttca acatgaaagc aactgttgaa 4021 gatgagaaac ttcaaggcaa gattaacgat gaggacaaac agaagattct ggacaagtgt 4081 aatgaaatta tcaactggct tgataagaat caggtttgtg tttttttttt tttttttcct 4141 cccccacgca atggagggga aggggatggt aaaccaagct tgagctggat ttcagtgtag 4201 ggtcacaatg atgaatggtc caaaacattc gcggtttcca ccagaattca aggtgttggc 4261 aactaccttc cttggatgtc tgagtgaccc aagatgttaa ggaagaataa ggccctattt 4321 taatgttggt atgggccctc ttgtaagagt ttgctccaga cttttagtat cagattgcgt 4381 cagggagaaa gaagggttat taacattaaa agaacttgca gtaattcctt tttctcttcc 4441 tcagactgct gagaaggaag aatttgaaca tcaacagaaa gagctggaga aagtttgcaa 4501 ccccatcatc accaagctgt accagagtgc aggaggcatg ccaggaggaa tgcctggggg 4561 atttcctggt ggtggagctc ctccctctgg tggtgcttcc tcagggccca ccattgaaga 4621 ggttgattaa gccaaccaag tgtagatgta gcattgttcc acacatttaa aacatttgaa 4681 ggacctaaat tcgtagcaaa ttctgtggca gttttaaaaa gttaagctgc tatagtaagt 4741 tactgggcat tctcaatact tgaatatgga acatatgcac aggggaagga aataacattg 4801 cactttatac actgtattgt aagtggaaaa tgcaatgtct taaataaaac tatttaaaat 4861 tggcaccata caattgcttt gagtctttaa ataatctccc aggccagcgg tgggagaagt 4921 aggcttaggt gattatgtga ctcttacttt ctccttcctc ttaagcttga gttaacaagg 4981 gctgggtggc aagttgccct tcagagcatg tggatggtac attttggaat tcagagcttt 5041 gagaagggga gcataagaaa ttggatctgg atcaaactaa ccttagtcct taggctggag 5101 aggcagaagc tgacttaatg gtgttttcta aacttattct gtgtgtaagc ctgcctagga 5161 gcagaggctt tcctggaggg ttgtgctaga tgagtaagaa tttagataca gaatcaaata 5221 atgggcagtg aatattaagc tacatggcag aggtatctga atgtcaatcc cttatatgag 5281 ccactgccct gtgggcttcc atttcttctg agttaagatt attcagaagg tcggggattg 5341 gagctaagct gccacctggt taattaaggt cccaacagtg agttgtgata gcctagggga 5401 gcaggctg //