LOCUS HSINT2 11608 bp DNA PRI 25-JUN-1997 DEFINITION Human int-2 proto-oncogene. ACCESSION X14445 NID g33937 KEYWORDS growth factor; int-2 gene; proto-oncogene. SOURCE human. ORGANISM Homo sapiens Eukaryotae; mitochondrial eukaryotes; Metazoa; Chordata; Vertebrata; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 11608) AUTHORS Dickson,C. TITLE Direct Submission JOURNAL Submitted (27-FEB-1989) Dickson C., Imperial Cancer Research Fund, P O Box 123, Lincolns Inn Fields, London, WC2A 3PX, ENGLAND REFERENCE 2 (bases 1 to 11608) AUTHORS Brookes,S., Smith,R., Casey,G., Dickson,C. and Peters,G. TITLE Sequence organization of the human int-2 gene and its expression in teratocarcinoma cells JOURNAL Oncogene 4 (4), 429-436 (1989) MEDLINE 89239468 COMMENT tissue=placenta; library=cosmid; clone=C1; Data kindly reviewed (04-Jul-1989) by Smith R. FEATURES Location/Qualifiers source 1..11608 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="11" /map="q13" misc_feature 445 /note="pot. transcription start site" misc_feature 479 /note="pot. alt. transcription start site" misc_feature 507 /note="pot. alt. transcription start site" misc_feature 527 /note="pot. alt. transcription start site" CDS join(936..1155,3445..3548,9197..9592) /codon_start=1 /product="int-2 preprotein" /db_xref="PID:g312409" /db_xref="SWISS-PROT:P11487" /translation="MGLIWLLLLSLLEPGWPAAGPGARLRRDAGGRGGVYEHLGGAPR RRKLYCATKYHLQLHPSGRVNGSLENSAYSILEITAVEVGIVAIRGLFSGRYLAMNKR GRLYASEHYSAECEFVERIHELGYNTYASRLYRTVSSTPGARRQPSAERLWYVSVNGK GRPRRGFKTRRTQKSSLFLPRVLDHRDHEMVRQLQSGLPRPPGKGVQPRRRRQKQSPD NLEPSHVQASRLGSQLEASAH" sig_peptide 936..986 exon <936..1155 /number=1 mat_peptide join(987..1155,3445..3548,9197..9589) /product="int-2 protein" intron 1152..3444 /number=1 exon 3445..3548 /number=2 intron 3549..9196 /number=2 exon 9197..9929 /number=3 polyA_signal 9911..9916 /note="pot. polyA signal" polyA_site 9929 /note="polyA site" BASE COUNT 2166 a 3822 c 3181 g 2439 t ORIGIN 1 ggatcctccg aggcctgcca gacgagagct aaccccacca ctccgggtgc ccagttggtg 61 tgcgcaaaag gagatagcat ctccagaccc ggcctgcccc gcgccttgca aggctgagga 121 cagcgccact gctcctgcag gaagcgccgg gcgcagacac aaacccggag ctccccacgc 181 gtgcccgcgc cccggagcct ccccgccgcc gccctccgcg gtccccttca ttatgcgccg 241 cctttaatgg gcgtttgtca gctcgacttc cccgcaagtt gttttcacgg acatcagtca 301 tcggcggcgg ccccattgtg cagggggatt gatggggagc gggagggggt gacagggcct 361 ggggcggcct cctcaaggcc tcggtctata attttcggag gcataattgg tctgggggag 421 ggggcggggg aggggcgggt aggggacctt tcagagccag gagggctttc gggggcgtgg 481 ggcgcgctgc ggagcggagc cgcggctcga cggcggtgcg ctggcggcga gtgtatgcag 541 acggcgcccg gcccgaaccc cgagccccgc ggggctcccc acccgccggc ctcccgcccc 601 tcccgcgcct ccgcctgggg accacgtcgg ccttttgttg gcgaaccgtc ctttctttca 661 gcgctttgcg cagcaacgga aatttcattg ctcctgggtg gaaattaaag ggactcgcgt 721 tccctctctc cctctccctc tcccactctc cctctctttc tctctctcgc ccacccttcc 781 cccttcttcc cccacctttc ccgcgaagcc ggagtcagca tctccaggcg cgggatcccg 841 ctccgagcac ctcgcagctg tccggctgcc gccccttcca tgggcgccgc gctcgcctgc 901 agccgccgcc gccgcggggc gggcgcgatg ccacgatggg cctaatctgg ctgctactgc 961 tcagcctgct ggagcccggc tggcccgcag cgggccctgg ggcgcggttg cggcgcgatg 1021 cgggcggccg tggcggcgtc tacgagcacc ttggcggggc gccccggcgc cgcaagctct 1081 actgcgccac gaagtaccac ctccagctgc acccgagcgg ccgcgtcaac ggcagcctgg 1141 agaacagcgc ctacagtgag tgccggacgc tgcggggccc cgggggaagc ggcgccggga 1201 ggggtcgggc ccgggagaag gcgcgctgcg gggccccgcg ggggaggcgg cgccggggag 1261 gggtctggcc cgggagaagg catggtgcgc ccggggtgtc cgggaaaaga ccgtctgcct 1321 cccgctgcca gaaggggaat gccagggtgc cctcctcaac ctacacgtcc gggagaagag 1381 cgcgcgctgg ggttcgagca gaactcgggg gcatgggcgt tcacgtccga agagggcgcc 1441 ggcggctgtc agagtccgtc cccggtccgg cccgctggtc tgaggggacg cgagctaggc 1501 gaccccgggg ctccaggctc tgctgctttg ggcagctctg acaagtttaa gccctttgaa 1561 tgtgtcggag aaaaggagcc ggacaaggca tttatcatct tctttattat tttgacgact 1621 tctcctcctc ctgccgaccc ctggacgccc cgccgtcccc tccgccctcc ccgctcgcgg 1681 ctgcccaggt ggccgccccc gctgctgcct ctgcgcggag gactcttgcc ctgcggagct 1741 cggttccctg gccgcggccg ccaccgacag ttttccccgc gctggaatct gcacctcccc 1801 cgcctccgcc ctggccgcac agcgacagga gggtggaggc cctcgccgtc gggacgtgcg 1861 gatcacgagc gcggaacggt gtccgcccgg gcctgggggt gcagacacac acactccggc 1921 ccccgcacgc aggacccgcg gcccgggctg cgctcaccgc gggagtctgc cggactacac 1981 ggttgggctc ctctggtcac agggacctga ggcccgcgcc gagccctttg aggagcagga 2041 tagcggagct cagggcccgg gaggaccgcg tggggagcgt gggagggcag tcaagaccac 2101 agctgtcctc gggtgctccg cgcggcgctc ggctccggcc ccgggcgcag gaagcggttc 2161 cgccgcttga aggtggcggc ggcggcctca gcaaaccgcg gcttcctcca ggaaagccgc 2221 agccctgaga gggcgtcctg gggacatgcg cctccggagc cgcacggtgg gcaccagctg 2281 tcaccagggg gtccgagtgc gcggaattcg tctcactaag acactccggt tctctccaaa 2341 gccaggctcc ccctcggagt ctcacagcat ccaaacttct tggtgttggc tgctcacggg 2401 gaggggaggg cgcgcgcccg cagccgcccc tgtcctgcgt cgagactcgt gcttcgctgg 2461 tccccggtca ggcaccgccg atgccgccca gcctgcgcac tgggaaggcg ggaggctcgc 2521 agcctgcacc acagcacccc tgggctggag caaaagcccg gtggtgaccg cgtctgtgct 2581 cggaccgcgt gccaggaggg cgctcctgag aggcatgcct tggagagggt gcaggcagtc 2641 gccccaatcc cctcgcagcc tctattggga gacaatgacc ccaacccgtc ctttgatgta 2701 gtcccccgcc cccagccccc accacagcac tcgtgtatcc agaaggaaag gcgggagggg 2761 agatttaaac tttcttatcc ctggggagtg ggtgagaccc gtccagcttc cctctgcggg 2821 ctccagggtc taaactggct tcctgccctt ccaggtcccc cggcgagtac aatgatctcc 2881 cgccaggtct attgccagca tgatttgggt ggcaggcacc ctggctgtgt tattgccagt 2941 ggtttatatt atcagcctgg ctcatcaggg cccagctttc ccgctggcag gcacaggcat 3001 tggggaccgt gcagtcccag agctcagact cccatggctg ccgccagggc ttgatttccc 3061 gctcaagcac atgtgcaggg gcctgacagt cacccagcca tagtggtccc cacttgcttg 3121 tctgtcggat gatgatggca gctggcaagg tgttgtgagg ctcgaatgaa agccagggtg 3181 caggcagcgt cagcaggtgg gaatgttaat ttcattgtta ccctcccaag tttgaatgaa 3241 gagaagcctt ccctgatgtt cccttctcta cctcctgtcc ggtgacttct cccttcctga 3301 acttccactc actccccgac ctgtggggtg tgtgctaccc tccccagccc tgagcccggg 3361 gtgtggcttt gggcagggcc agctgggcct cagccgcccc ctccgtgggg gcggcgggag 3421 tgaggcacct ctcatttctt ctaggtattt tggagataac ggcagtggag gtgggcattg 3481 tggccatcag gggtctcttc tccgggcggt acctggccat gaacaagagg ggacgactct 3541 atgcttcggt gagtccaggc tgtcacgtgg gtgggcgctg acggagtagc ggtctggcct 3601 gcacatcaag ccaggggacg ggggatgtgg gcagtagaat gctttgccaa gggtacatgg 3661 gatccaagct aggaccagac cctggcccag ggctccacgc ccagtgatct ttggctgtgt 3721 ctgttagagg ctgctccgcg agtgacctgg agcctggccc tgggggacct gggatctgga 3781 gaatgccagg ttagcaaagg tttcccccat ccttgtcatc actaccaccc tcccttgaga 3841 gtagctgaga gcagggaagt gattgttctc caaatttcca ccaaaataaa tggacccaag 3901 acaacctggg agtgttcctt ggggcagcca gagctctcct gggagcatgg agaggagggc 3961 gctggcccag ctccaccggc tctctccaag ggtggaaagg cgagagctga agcctaggag 4021 gggaaggggg atggcgccca tgtcccgggc acacaggagc cttggagccc tggcttggga 4081 cccagtctat ctactgcctg ggcctccgtg taaccaaaaa gggtctcctt attctgtggg 4141 tatggcagcg cccctcttca taaggggtag gggtggggaa tacacagagt aaaatacatg 4201 tcacagggaa atttgctacc tccaactagt cattacatgc aatttggctg atacttcctt 4261 gggcaatgag aggttttcca tccatgagta gcctggctga cgcggcccaa ggacaatctc 4321 cctgcagtga gctctctgct cagtcctgct cacagaggac acatcccgca gctccctctc 4381 gcagaagctg atgatttcat cacagatttt tagccgtttt gctaaaggaa ggtccagaaa 4441 gccgggatgc gccccttcat tttctctggt ccagaggcta ctccctcctt cctcccatcc 4501 actcacccat ccacccatcc acccattcac ccatccactc atccacccat ccacccatcc 4561 atccatccac tcatccaccc atccacccat ccatccatcc acctatccat ccatccatcc 4621 acccatccac ccatccttcc atttacccat ccaccatcca cctatccatc catccatcca 4681 cccatccacc catccaccca tttacccatc cacccatcca cccatccacc tatccatcca 4741 tccatccatc cacctatcca cccatccact catccactca cccatccacc tatccaccca 4801 cccactcacc catccatcca cccacccact cacccatcca tccatacacc tatccatctg 4861 acattcagtc cattcatcag tcagtgtcct ggaagctgtg tctgggagca ggggccctca 4921 tggtgccagc ttctgccata ggggagccag gatttggaga gacagaataa agcatgacat 4981 gagggggtcc cagtggttca gagcccacct ggggcttccg tgcctgagaa ctcacagcct 5041 ggctttgaga agggtggaca gaggctccta gccccaccag ggatgcttag ccaagcagtc 5101 tggctggagg gtgtggaact ttccagagtg cccagtggag aagttcccat tgccctgcag 5161 acaacctggg aggcatagta gcctggatgc caactccgtc acctgccacc tgccacctga 5221 taccacagtc ctgcgtgtgg ccagcttgcc taggagtgct gtcccaccac ggggctccct 5281 ggactttgcc ggcagcatgc ttgccctcag gccagctcat ctcactgtgg gccagtgagc 5341 actgcaccct gacactcctg gtctggccct gacctccctt ctgaggtata gaccaccctc 5401 ccccaacatc ctgctgactc agacactcca accgaactca gcagctcccc gactccccat 5461 cttaatcatt gccccaccag ccactcactc tcacccagag tggactggga gtcatggtag 5521 acccctcctg ctattcagtc catccctagt cctcagacca cgcccctgca tctcttcagc 5581 ccacacacct cacctccctc tgcctcatcc ccgagagcac gccttaaaag gcaggctcat 5641 cacttcccac ctggatcact gctccagcct ctcctacctc cagtccatct gtttgtcaag 5701 ccatccatcc atcttccttc cttctttccc cttcctttat tctcttcacc catctgtcca 5761 tacacctctc cttccttcct tctttccttt ctctcatcct tctttccatc catccttcca 5821 accgttcatc tgtccatctg cccattcaca tgtccatccg tccatgctcc ctccttcctt 5881 ccatcctttc acccatccac ccatccaccc atccacccat ccaccaatcc atccagcaat 5941 ccacccatcc atccagccat ccacccatcc atccgtccac ctatccatcc atccacccat 6001 ccatccaacc agccatccac ccatccatcc atccatccat ccatccatcc atccacccac 6061 ccacccatcc acccatccat ccatccagcc aaccagccat ccacccatcc acccatccac 6121 ccatccatcc atccatccat ccatccatcc atccatccat ccacccatcc acccatccat 6181 ccatccagcc atccacccat ccatccatcc acctatccat ccatccacct atccatccat 6241 ccacccatcc atccatccag ccatccaccc atccatccat ccacccatcc acccatccat 6301 ccatccatcc atcaatccat ccatccatcc acccatccat ccatccatcc acccacccat 6361 ctgacattca gtccttcgtt caccagtcag tgtcctgggc acttaccatg tgttgcactc 6421 tgctagtgca tgttaaaggg gcttcctaaa aaagcaaatc agcccagttc atggcttctg 6481 aggactccca tgatgcgcag gcatccccca ggcaccttag ctccacccac agagcagcag 6541 cccaggtgcc atctgctccc aggggggccg tcatccagag gttgagcctc ctccagcttc 6601 cggaagcccc ctcaactctc caagccatct gtactgctca ggccacacct tcactgcctg 6661 gaacgccctc ctccagaaaa tgcccatgag aaagtgcccg ccccgccctt acagctccct 6721 ttagaagtca cctcctcaac aaagcagctt cggagtcggc ttcctcccca cccttcatgg 6781 ggtggaagcg gccctggggg aggggcctgt ggaaccaggt ctggtggggc ggcagtgtca 6841 ggacacacat tggaaagtgt tgtcacagcg agtcccaact gcagtagctc tggagtctat 6901 ggccccggcc cctgagccaa caccttctgc cctggtcatc ttggccaccc caggtgccct 6961 accacgtgtc agcaattgat ctacactgcc cccaatctcc cacctcggga gagcctgagc 7021 cccctgccac ctgaggctca caggcacctg tccttcagtg acccacccct caagtggccc 7081 cccaaagaga aagcctattt cctggcctct ctggccctga gaggactcac ctgctgcagg 7141 atcgagggac ctgggagaag cttgggtcct gccctgagct tctcacagtc tgccatggga 7201 gccagacact aacatgttgt acccagtgtg tggggtgggg aagtcggccc tgagcccacc 7261 cgctcattcc cagatagtcg ctgagcccca ggctatgtgg gggtcaggca cagatcagac 7321 actgttctat cccctgtaat gtagggcctg gcaccacccc tgggcctcag tttccccatc 7381 tataaacatg gagaccggtc ttggatagta acatccagac tgtggcccag ggggcactgg 7441 gcctccaaga gggctggaga gcaggggggc ttggggttat ggggagaggc agcccctacc 7501 accaggtcaa gccttccacc cttccctgct ctgggctttc atgtcgctga aaaacaggat 7561 ggggtgcttg aagcatcttg ttccctgagg tcctgcgagg tcagatgctg ctcggtccag 7621 tctgggagcc tctggaggcc atttccactc tccctctctc ccacgggaca ccacacccca 7681 gatggggaca gaccatgagg gcctccgact cctcctgcgg ccagtcccca ggaggaaaga 7741 gagatcctac tgtctgcctt gcacctgctg cttccacctc ccaccaccct ttctggtttg 7801 gagggagcag ctcctgtcag tcatcccctg agggaggtgg ccctaggcat taccacttgc 7861 ctgtagctgg gactgaagcc tagtgggtct gcataaggca tacccacctc ttccctacgc 7921 cacagactaa gaagacccca tgaggcagcc cttgagggaa actcccacgg ccaggccttg 7981 gggatgttgg tgtaagctcc ttcagttcag agcttcactg tgcctttgag agggcagggt 8041 cccttctgcc cttcccccac tgcaccctgg gcctgacaag ggtcccatta atctctgatg 8101 acaaagaggt gtcctctctg tcctgcttgt ggtgggacac cccagcttct gctctcatcc 8161 taagaacagc agtatctgtg gcactgattg atcacgtgcc tcatgccagg ccccagcccc 8221 tgctctgtgt tgtaacctct tcaacctgca aggcgagatc ctccagctta agagagtgtt 8281 gctcaggggt caatgacccc agctggggcc cctgagcgca gcgtttaatg gagagtctgg 8341 gctcatcaaa cctggctgtg tccccttccc ttcctgcttt ttgtgttctt tcttcttttt 8401 acttttctgc aatttctttt tttttctttt cttttttttt ttttttgagt cagagttttg 8461 ctcttgtcgc ccagactgga gtgcagtggc acaatctctg ctcactgcaa cctctgcctc 8521 ccgggttcaa gtgattctcc tgcctaagcc tcccaagtag ctgggattgt gggcgcacgc 8581 caccacaccc ggctaatttt tttgtatttt tagtagagac ggggttttgc catgttgccc 8641 aggctggtct cgaactcctg acctcaggtg attcacctgc ctcggcctcc caaactgctg 8701 ggattacagg catgagccac cgtgcccagc ctctgcaatt tctttaaaag agatctgggt 8761 gttgtcatct tcctttgtcc aaatgcccag tccttgctga cctccacact gccagcagac 8821 tgccagggca cctgggttgg ccggcctggt ctctgctcca cagacaaccc tacacatccc 8881 tttgctgtgt cagcgccctc agatggggga cagaggctgg tggaacccag agagtaggag 8941 ctgggagttg tctggcacag ctttgagtga aggtgacctt taggcagaag gccaagttca 9001 ccaggcacac aggggaggaa ggacatgctg ggcagagggc agggcctagg caaaggtgtg 9061 actggctgag agtgcgctgg ggtttggcac tggaccgaac agcctcacag gaggggaggg 9121 aggcatcagg caaccctggg ccctgacgct gccgcagtct ccccggggca ctgaccatga 9181 tatctcatcc ccgcaggagc actacagcgc cgagtgcgag tttgtggagc ggatccacga 9241 gctgggctat aatacgtatg cctcccggct gtaccggacg gtgtctagta cgcctggggc 9301 ccgccggcag cccagcgccg agagactgtg gtacgtgtct gtgaacggca agggccggcc 9361 ccgcaggggc ttcaagaccc gccgcacaca gaagtcctcc ctgttcctgc cccgcgtgct 9421 ggaccacagg gaccacgaga tggtgcggca gctacagagt gggctgccca gaccccctgg 9481 taagggggtc cagccccgac ggcggcggca gaagcagagc ccggataacc tggagccctc 9541 tcacgttcag gcttcgagac tgggctccca gctggaggcc agtgcgcact agctgggcct 9601 ggtggccacc gccagagctc ctggcgacat cttggcgtgg cagcctcttg actctgactc 9661 tcctccttga gcccttgccc ctgcgtcccg cgtctgggtt ctcagctatt tccagagcca 9721 gctcaaatca gggtccagtg ggaactgaag agggcccaag tcggagctcg gagggggctg 9781 cctgcaatgc agggcatttg tgggtctgtg tggcaggaag ccggcaggga agggcctgag 9841 tgccagccct ggcagactga ggagcctccc aggagcagcg gggcagtgtg gggctttgtg 9901 tcatcacaac attaaagtat tttattctac tctgtcgttt ggtagaccgt gatgcaggct 9961 gaggagcgct tgccgccttt actggaacgt gcttgcttcc agcacagcag aatccgcgct 10021 ggcatcagcc tgcgtcagct gctgctttaa gaggaagacg gcattcccag aaatcgggct 10081 aaaggtgcat ttcagttccc tggttttaga aagttacgtt tttttggatg gttggaaaca 10141 agcaaaggca tgtttgtgca tgtgtgtgca tcgtgtgtgt gtgcgtggag agaaggatcg 10201 tgtatttctg aaagcgtgag tgtgcatgtg ggtatgtgtg atcttgtgtt agtggtacct 10261 gtgtgaggac atgtatgtgt gtgtgtgttt ctgggtgtgt ctgaatgtgt gatgtgtgtg 10321 tgtctgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtggaga gagagagaga gagtttactt 10381 tctttgaaaa ctctaaaaag cctctccctc tggaagctgt gtgcttctcc agggaccctt 10441 tagagcaact gtgtcaggtc aggcagcaca gaaacttcct ttatccttac aacctgctct 10501 tggggcccgt gcaccctgtc tttacctaga aggtgaggct cagagaagca attactcagt 10561 ggccggcccc tgccttggac taggtgcctc ctcacacctg ttccccaaca atggcatggg 10621 tggaatcacc tgggccggcc caggtgagag ccagcatggg cagtgtacta acctctcctg 10681 gcacttggca ggatgggcag ggtccaggtg aggaggctct cctgagcctg ggactgtgag 10741 gaccatcgct ctctgttccc atgccctccc aggggtcaga gagcccagac tcagagagcc 10801 cagggtcaga gaacttaggg tcagagaggc cagagtcaga gagctgagac tcagagagcc 10861 cagggtcaga gtgtccaggg ccagagagct tgtggtcaca gagcccagac tcagagagcc 10921 cagactcaga gccacctgat tggttagtgc agactcgcca aacccacagg gaggctgggc 10981 tcctccctgg cacgtgtgca acacaagtga aaatctcggt gcctccttca gcccccagcg 11041 catgtcagat ttcccggaat ggctcccctg cagctgcgaa cattcctggc agtcaacagg 11101 agcagcacgc agctgagctc tgctgtgggt tttgttgttt ctctagagtg agatggggca 11161 ggggctgcca tcactccctc cttgcagatg atgaccctga gtcctggcaa ggggaacttg 11221 cccggggctg tgtcaacaca ggggaagcag cagtactcag tgctgcagga tcaacagatg 11281 gtccctgatg aaggcgtagg agacactggg ggctcttgtt taacatgtaa aacagctttg 11341 acaagagaat gtggattttt cgcagctgat ggctgtgcca tggtcacctt cttccccaca 11401 ccagagtcca agggacttca ttttgtgtgt gtgtttgggg ggtcatgggc tgaattatgt 11461 ctcctcccca gagttcatct gttgaagtcc taacccctag taactcagca tgtgacctta 11521 tttggaatag ggtcattaca gatgcaactg gtgaagatga ggtaacatag gagtagaatg 11581 acccctgaat ccattgtgac caggatcc //