LOCUS HSPROPG 8222 bp DNA PRI 30-JUN-1993 DEFINITION H.sapiens gene for properdin. ACCESSION X70872 S46256 NID g35679 KEYWORDS activator; complement; properdin. SOURCE human. ORGANISM Homo sapiens Eukaryotae; mitochondrial eukaryotes; Metazoa; Chordata; Vertebrata; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 8222) AUTHORS Nolan,K.F. TITLE Direct Submission JOURNAL Submitted (15-DEC-1992) K.F. Nolan, MRC Immunochemistry Unit, Dept of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK REFERENCE 2 (bases 1 to 8222) AUTHORS Nolan,K.F., Kaluz,S., Higgins,J.M., Goundis,D. and Reid,K.B. TITLE Characterization of the human properdin gene JOURNAL Biochem. J. 287 (Pt 1), 291-297 (1992) MEDLINE 93038568 COMMENT X70872 and X57748 are related sequences (genomic vs. cDNA). FEATURES Location/Qualifiers source 1..8222 /organism="Homo sapiens" /db_xref="taxon:9606" /cell_line="GM1416B (PLUS ?)" /clone_lib="COS4X PLUS ?" /clone="COS4XP, G3" /chromosome="X" /map="Xp11.23-Xp11.3" repeat_unit complement(26..86) /rpt_family="ALU-like" repeat_unit 491..777 /rpt_family="ALU-like" repeat_unit 1053..1343 /rpt_family="ALU-like" exon 1745..1921 /number=1 mRNA join(1745..1921,2141..2281,2376..2526,3774..3949, 4410..4580,4719..4910,5105..5278,5532..5723,5882..5993, 7610..>7824) /note="alternative" mRNA join(1749..1921,2141..2281,2376..2526,3774..3949, 4410..4580,4719..4910,5105..5278,5532..5723,5882..5993, 7610..>7824) /note="alternative" intron 1922..2140 /number=1 exon 2141..2281 /number=2 CDS join(2206..2281,2376..2526,3774..3949,4410..4580, 4719..4910,5105..5278,5532..5723,5882..5993,7610..7775) /codon_start=1 /product="properdin" /db_xref="PID:g35680" /db_xref="SWISS-PROT:P27918" /translation="MITEGAQAPRLLLPPLLLLLTLPATGSDPVLCFTQYEESSGKCK GLLGGGVSVEDCCLNTAFAYQKRSGGLCQPCRSPRWSLWSTWAPCSVTCSEGSQLRYR RCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRR RACNHPAPKCGGHCPGQAQESEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKE TRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLG QTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKS ISCQEIPGQQSRGRTCRGRKFDGHRCAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCM PPCGPNPTRARQRLCTPLLPKYPPTVSMVEGQGEKNVTFWGRPLPRCEELQGQKLVVE EKRPCLHVPACKDPEEEEL" intron 2282..2375 /number=2 exon 2376..2526 /number=3 mat_peptide join(2381..2526,3774..3949,4410..4580,4719..4910, 5105..5278,5532..5723,5882..5993,7610..7772) /product="properdin" intron 2527..3773 /number=3 exon 3774..3949 /number=4 intron 3950..4409 /number=4 exon 4410..4580 /number=5 intron 4581..4718 /number=5 exon 4719..4910 /number=6 intron 4911..5104 /number=6 exon 5105..5278 /number=7 intron 5279..5531 /number=7 exon 5532..5723 /number=8 intron 5724..5881 /number=8 exon 5882..5993 /number=9 intron 5994..7609 /number=9 repeat_unit 7329..7485 /rpt_family="ALU-like" exon 7610..>7824 /number=10 polyA_signal 7819..7824 BASE COUNT 1920 a 2184 c 2246 g 1872 t ORIGIN 1 gtcgacaagc ttatcgatac agctggatcc acctgcctca atctcccaaa gtgttgggat 61 tacaggcgtg agcaccatgc ctggccagtt tcaggtctct tggagagtgt tttcacagga 121 taacacagca atgattgtct tgaagtcgta gaatcttaat aagactcctt tgttcaaagc 181 acattttcaa ggatagcctt atgttatcag agaacagagt atgtctgtaa tggatacaga 241 tattaacaca tactttactg cccataaaac aagtgttcct gaagaacttc tgttttaaca 301 gctgaccaaa ttattacatt tgaatttgca gaattcctct gcctccctga gagcagagga 361 aattaggcat tgccttccta tctttcttgt gcttcttttt gttattaaaa gcaaaataaa 421 aattttaaag tgggccctgg agtttcatta gggtttataa aaaaaaaata aaaaaataaa 481 aaaaaaagaa gggctggtgt gatggctcat gcctgtaatc ccagcacttt gggaggctga 541 ggttgggaga aaatattgaa gccaggagtt tgagaccagc ctgggcaaca caacgagacc 601 ccatctatac agaaaataaa aacattagtt gtgtggtggt gtgtgcctgt agtcccagct 661 acttggggac gctaaggtgg gaaaatcact tgagcccagg agtttgaggc tgcaatgagc 721 tatgatcaga ccactgcact ccagcccagg tgacagcaag actctgtctc tttaaaacaa 781 aacaaacaaa aaaacaggtt tggaagctac tgggctagag agtgacaggg atgccagaca 841 agggtatggg gaaggcctct gtgaggaggg gcaacatttg ttatccatct tctcgagggc 901 caggattttt gtctgtccta ttctctgctc taatgctaag aaccgcatct ggcatccagt 961 aggtgctcaa taaatgttga ataaatttat caaacacaga gcacctacta tatgccaggc 1021 actgttctaa agactttcca aaagcttaac tcctggccgg gcacggtgac tcacgcctgt 1081 aatcctagca ctttgggagg ccaaggcagg tggataacct gaggtcagga gttcgagacc 1141 agcctgccca acatggtgaa accctgtctc cactaaaaat acaaaaatta gctggacatg 1201 gtggtacacg gctgtaatcc cagctactca ggaggctgag gcaggagaat tggttgaaat 1261 cgggaggcag aggttgcagt gagccgagat cgtgacactg cacgccagcc tgggcgacgg 1321 agtgagactc catctcgaca aaacaaacaa aagcttaact cgcaatcttt gcaacacacc 1381 ctacctatgt tgtaggtgct gtctgtgagc acattttaca gaggggaaac aggctccaga 1441 aggggggtgt tatctgcctg agggttctct gatggaatat ggcccagctt attccctcct 1501 aatcacccca gaccctggtg ttgtccccag ctgggcccat ggaacaatgg atagacccca 1561 ttcccctcct gaatccctcc ccaggctcct gccacttccc tttctcactt cccttgtgct 1621 gacctccccg accacaagct gaccacaggg aacctctcag gaaaggaggg ccgaggttaa 1681 gggagggtgg aaggtggagc aactgactcg atgctccctc cacccccacg agcaggaaca 1741 tactgagcac cgcacactca cttcaccctg gttcaacacc cccacgaggt tgaccccgtc 1801 attatgttag agattatgca ttttccacat agggaaactg aggctcaggg gtgttaagtg 1861 actcacccaa ggtcacacgg ctaggaagtt gctgcacgct cctatgctcc atttcctctg 1921 ggtgagaatt tgtcctagga gcttctattg aacactgtga ggttgctggg aggagcgcga 1981 ggtgctgggg atatagtaac aaacagaaca agaccaagag taagacagga aatggggagg 2041 ggagagtaga gaaggaggca gaggggacag ggtggggtca aagcaggatg ccctcccagt 2101 tcctcctgcc tctaggttcc tctttccctg ctgattccag gagcctatca acccagataa 2161 agcgggacct cctctctggt agaggtgcag ggggcagtac tcaacatgat cacagaggga 2221 gcgcaggccc ctcgattgtt gctgccgccg ctgctcctgc tgctcaccct gccagccaca 2281 ggtgaggggg tgagggccca gctggcccca ggggtgtcca ggcccaccac atccctgacc 2341 gagccccacc cacccatccc ctggccctgt tacaggctca gaccccgtgc tctgcttcac 2401 ccagtatgaa gaatcctccg gcaagtgcaa gggcctcctg gggggtggtg tcagcgtgga 2461 agactgctgt ctcaacactg cctttgccta ccagaaacgt agtggtgggc tctgtcagcc 2521 ttgcaggtta gggggagcct ggggtggggg atggggggga gggaaggact gtctgtgggg 2581 gtcacccaaa actgggcact ttctttctct gggacttcca agggtggccc tgaggccctg 2641 atcgtgacca tacctcaggg tttctcaacc ttgttactat tgacatttgg ggctggaaat 2701 tcttggctgg gggaggggat tgcttacctg tgtattgtgg gatgttttgt aacaccccta 2761 gccttccact agatgccagt agcaattctc cccaccagct gtgacaacca aacatgtcag 2821 cagacattgc caaatgtccc ctgggggtca aaatcacccc tgattgagaa ccactgacat 2881 agctcacaca tattgagcac ctcctgcaca ctggaagcat tgcaggtggg gtgcagcttg 2941 gtatttccct aattttgatg acagctcatg tttattgagt gcttactgta tatggacaca 3001 ctgtgggggc gggaaagttt ggggaattca aagggcagct ctaggcccct aattatgatg 3061 acacttcaca ttcattgagc actccctgta taccagctgc atggcagggt tgggagatga 3121 gcttgaggat ttctgagggt agctctagtc tcctgatcat gatttccagc ttgcatggat 3181 tgagccctta ccgtatgcca gacctgtttt ctacttgttt actatatatc ccagatacac 3241 cgtgggcatg gggagcttgg ggatttttga gggcagctct gggccccaag tcatgtcaac 3301 agttcatcac atctatttgg catgaacagc atacctaggg ctatgcagtg ggttggggat 3361 agatctgggg ttatttctga ggaggcctct gaggtcatag ggatgatggc tcaggtttat 3421 taagcacttt ctatttacct actaccgtgt agtgtggtga tctggtgggt ttctgacagc 3481 agcccttggt ttctagtcct tacctttgct tactgcggac ctggtgttgg ccatgccagc 3541 cttccaatgg taactccaga tgcctgattg tgaaggtaaa tgacattatc aagcacttat 3601 tgtatatcca ctgcttccca tcagtatccc aatatcccta aaaggtaagg acttatcaat 3661 ccatcgcaca cgcacttgcc tagcaaccct tcgtgtctgc ccacactctg gagtcccaca 3721 tgccattctt gttagctcat gccaggatgg gatgtgtgtg ctcttctcca caggtcccca 3781 cgatggtccc tgtggtccac atgggccccc tgttcggtga cgtgctctga gggctcccag 3841 ctgcggtacc ggcgctgtgt gggctggaat gggcagtgct ctggaaaggt ggcacctggg 3901 accctggagt ggcagctcca ggcctgtgag gaccagcagt gctgtcctgg tgaggaggat 3961 gagcaaggcg ggcaagcact ccctgtcacc cagcactggt gggaacgatc ggtacagagg 4021 tcctcagagt gggcccgtcc ccagtgtttg taaggaccta aggaggagag tggtgggagg 4081 tgaggtcaga gaggtgagga gggtccattg cctgggggcc acagagagga cgttggcttt 4141 tcatctgagt aatttggact gtgggcagag gaggaacgtg atctgactgg ggttgggagg 4201 agaacagact gtgcacggtg agggtgagag gggaagcgga ggcacccatg tgaaggttgc 4261 tgcggcaggc ccggtgagcg gggatggtgg gcccagaatg gtggcagagg atataaggac 4321 aggattagct catgtggggc actcaaggaa gcaaagagcc ctgaatgaca ccccacctcc 4381 atcccattac cctctcttct ctcccacaga gatgggcggc tggtctggct gggggccctg 4441 ggagccttgc tctgtcacct gctccaaagg gacccggacc cgcaggcgag cctgtaatca 4501 ccctgctccc aagtgtgggg gccactgccc aggacaggca caggaatcag aggcctgtga 4561 cacccagcag gtctgcccca gtgagtgagg gaagccacag gatgctgatg ggtgcaccca 4621 gcgtgggtct gcggggttac agcagggaac tgccaggctg agaggacttt agcatgcatg 4681 accacacctg catccctcca cctcccaccc caccacagca cacggggcct gggccacctg 4741 gggcccctgg accccctgct cagcctcctg ccacggtgga ccccacgaac ctaaggagac 4801 acgaagccgc aagtgttctg cacctgagcc ctcccagaaa cctcctggga agccctgccc 4861 ggggctagcc tacgagcagc ggaggtgcac cggcctgcca ccctgcccag gtacaccagg 4921 atgaggctgc tgatgttgct ggtggggctc ttgattgagg gcagagatgc tctgccattt 4981 ctagagttcc taggccatgt gaccatgcag cccttcattt ggggacagtc tgcttcaagg 5041 gtctaggggc tgagaggaag gattgaggag gcctttctcc tcactccctt tcctcctcca 5101 acagtggctg ggggctgggg gccttggggc cctgtgagcc cctgccctgt gacctgtggc 5161 ctgggccaga ccatggaaca acggacgtgc aatcaccctg tgccccagca tgggggcccc 5221 ttctgtgctg gcgatgccac ccggacccac atctgcaaca cagctgtgcc ctgccctggt 5281 cagcatctca gggttcacga tttgcatgcc taagtccccc ttgcccttct ctgctgccca 5341 gctcctgctg ctgaggcctt gttcctgtct ctgattcctc ctttcctggc cctgatacct 5401 tgtttccacc cctggtcccc cattcacaca tctgatcacc tctactccct cctaccgccc 5461 tcattccttc ctctgaaccc ccttgctgat tccctgcttt ggtccaatcc cctgttgccc 5521 tgtctctgca gtggatgggg agtgggactc gtggggggag tggagcccct gtatccgacg 5581 gaacatgaag tccatcagct gtcaagaaat cccgggccag cagtcacgcg ggaggacctg 5641 caggggccgc aagtttgacg gacatcgatg tgccgggcaa cagcaggata tccggcactg 5701 ctacagcatc cagcactgcc cctgtgagtg tcccacagac tgtgctctga gggtggggtg 5761 gcccatgcag gataaggggt ttccaactct ctgctgtgga cctcacgtct ctgcagcctc 5821 cctctcactt tcccaccaag acctccagtt ctgactctgt gacccctacc cctcattgca 5881 gtgaaaggat catggtcaga gtggagtacc tgggggctgt gcatgccccc ctgtggacct 5941 aatcctaccc gtgcccgcca gcgcctctgc acacccttgc tccccaagta cccgtgagtg 6001 agagggcaaa gtatgcctgg gagggggtca ttatattaca ggcgggagag tcggctaccc 6061 caggaaacca gggtttccac tgctgaatct aaggtatctg ccttgccgag tgccacctcc 6121 cagctgcagg aagtggggag aaactaagaa gatgagaaag aagttcttgg aggataattc 6181 gtagcctctg tgcccctcag tcacttgttc agtcactcat ccacttagtc cttcatgtgt 6241 cattgactcc gaccttcagt tacccatgct tttagctgcc atcactcagg cctccattca 6301 ctgcctgcct cccacagtca ctcatgcctc catccacttt ctcagcatct cactgagcca 6361 aggcactcca aggctttttc agcaacagtt gcagatacac acagcccaga tcctgtggat 6421 cctccaaggg acccagctga gcaagccctg acaggaggca tatgaggaac agctggtgca 6481 tgcaacaggt gctgccacct caacctaggt ccaggaagct gactgggcct cccagggcag 6541 gtaggggttg ggaaaggcat tcctggcatc aagactgtga acggagcctt ggagctaggt 6601 gattagccgc tataagtgtt tccaggtgcc agaggggccc aggtgttaga gagggttaaa 6661 atgttcatcc cttttcttcc ttccacatac atcaagctac tagattaagt gaactattcc 6721 cagctcgtgg aagggctgcc atctgggaag ggatctcccg gctgaggggg ttagagtggg 6781 gcctgaagat tagaggtctt gaatggaggc acaaaggact tgagtgagcg agagactgag 6841 tggaggaaga agcaattgag agaactggga tgggagtgaa tggagggctt tcctagtggg 6901 acaaataacc caggtaaaga cctttctgga cagggactga gcttgaataa agtggaggag 6961 acagagagag agattggctt ggggcaggga tttgggccca acaataaggc cttgaatgtc 7021 aggacaaggc attgggtttt ttcctggagg cagtggaaag agatataaag ggtatatatt 7081 tcggaggtaa aagaaagtag ctcatgccaa caagtaacat tcaccagcat ttattgagca 7141 cttgctgtgt gccaggcact gctctgagca ctttacctga attaactcat ttatcctcat 7201 tcaaccccgt gaggtgagta ttaatattac tattcctacc attctcattt tgcagatgag 7261 ggaaaccgag gcacagagaa gctaaagaaa ttgcccaata tcctatagct aaaaagtagt 7321 gttgggaggc caggcacagt ggctcacgcc tgtaatccca gcaacacttt gggaggctga 7381 ggcaggagca tcacttgagc ccaggagatt gaggctgcag tgagctatga ttgagccact 7441 gcactgcagc ctgggcaaca gagtgagacc ctgcctcaaa aaaaaaaaag gaaaaaaaaa 7501 aaaaaaaaaa gtagccctcg gcatatagca ggcactcaat aagaattgaa tgcattcttg 7561 ccttccctga gattctccct tccgttcctc cccaccccta atgcctcagg cccaccgttt 7621 ccatggtcga aggtcagggc gagaagaacg tgaccttctg ggggagaccg ctgccacggt 7681 gtgaggagct acaagggcag aagctggtgg tggaggagaa acgaccatgt ctacacgtgc 7741 ctgcttgcaa agaccctgag gaagaggaac tctaacactt ctctcctcca ctctgagccc 7801 cctgaccttc caaacctcaa taaactagcc tcttcgagtt cgtctacgat tccttaaagg 7861 aggaaaaaca acctatcccc ttccccaaaa gtagggtgat agcatctcat agggcaaaca 7921 gcacagcacg ggccaagaca cagcagcctg ttgcggaaaa cagtattttc cactgtggtc 7981 gcaggttggc aggagtgaaa gcgagtgtgc agtcccagcc tctccccgcc gctgccataa 8041 cccaatgtct gggccctgcg cagccccctt agagcctcag ggccgcccgg cacgttcctc 8101 tgcagagctc cgcgttacgg gtttcctgat tggctacttg tcctggcagg cacttcttga 8161 ttggccggcg tgcttgttcg ttgtctcccc gtctcctgga cctccctaga ttcccaccag 8221 cg //