LOCUS HSSLIPG 2657 bp DNA PRI 30-MAR-1995 DEFINITION Human SLPI gene for secretory leukocyte protease inhibitor. ACCESSION X04502 NID g36485 KEYWORDS elastase inhibitor; protease inhibitor; secretory leucocyte protease inhibitor; trypsin inhibitor. SOURCE human. ORGANISM Homo sapiens Eukaryotae; mitochondrial eukaryotes; Metazoa; Chordata; Vertebrata; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2657) AUTHORS Stetler,G., Brewer,M.T. and Thompson,R.C. TITLE Isolation and sequence of a human gene encoding a potent inhibitor of leukocyte proteases JOURNAL Nucleic Acids Res. 14 (20), 7883-7896 (1986) MEDLINE 87040761 REFERENCE 2 (bases 1 to 2657) AUTHORS Rogaev,E.I., Keryanov,S.A. and Malyako,Y.K. TITLE Dinucleotide repeat polymorphisms at the P1, HBE1 and MYH7 loci JOURNAL Hum. Mol. Genet. 1 (4), 285 (1992) MEDLINE 93265040 FEATURES Location/Qualifiers source 1..2657 /organism="Homo sapiens" /db_xref="taxon:9606" promoter 181..184 /note="put. CAAT-box" promoter 242..247 /note="put. TATA-box" mRNA 276..375 /note="put. exon 1" precursor_RNA 276..2574 /note="put. primary transcript of SLPI" CDS join(291..375,1092..1250,1668..1817,2397..2401) /codon_start=1 /product="secretory leukocyte protease inhibitor (SLPI)" /db_xref="PID:g758101" /db_xref="SWISS-PROT:P03973" /translation="MKSSGLFPFLVLLALGTLAPWAVEGSGKSFKAGVCPPKKSAQCL RYKKPECQSDWQCPGKKRCCPDTCGIKCLDPVDTPNPTRRKPGKCPVTYGQCLMLNPP NFCEMDGQCKRDLKCCMGMCGKSCVSPVKA" sig_peptide 291..365 /note="signal peptide (AA -25 to -1)" mat_peptide join(366..375,1092..1250,1668..1817,2397..2398) /gene="SLPI" gene 366..2398 /gene="SLPI" intron 376..1091 /gene="SLPI" /note="intron I" mRNA 1092..1250 /gene="SLPI" /note="exon 2" intron 1251..1667 /gene="SLPI" /note="intron II" mRNA 1667..1817 /gene="SLPI" /note="exon 3" intron 1818..2396 /gene="SLPI" /note="intron III" mRNA 2397..2574 /note="exon 4" misc_feature 2549..2554 /note="polyA signal" polyA_site 2574 /note="polyA site" BASE COUNT 545 a 649 c 704 g 759 t ORIGIN 1 agggctctag atggacactg agacggcctc tttaatcaac caacttccca ggccaatctc 61 ttccctttct tttctcgata gttgctgtgt ttggcctcat agccttacct ggcataggaa 121 agataaacaa tctccttggt gtcaggattt ctggtttttg gttagggttt cctgcttatg 181 caatagtagc tgggagaggc ccgaaagaat tctggtgggg ccacacccac tggtgaaaga 241 ataaatagtg aggtttggca ttggccatca gagtcactcc tgccttcacc atgaagtcca 301 gcggcctctt ccccttcctg gtgctgcttg ccctgggaac tctggcacct tgggctgtgg 361 aaggctctgg aaagtgtaag ttggagtcac tgtctaatct gggctgcagg gtcagaggtg 421 gggtctcctt gtggtgtggg tgtgtcccct tctgtaggct ctgatccctc agcttagttt 481 cgggagacct ccctgagggt ggaatacatg tctggctgag ctccaaggtt tgtgtgacag 541 tttgagcttc tggaaatgct tcctctatgc agccatgctg tcagcccagg tcccactctc 601 tctctctctc tctctctctc tctctctcat actccgcctt cttcttcacc ttgctgcgac 661 tctcaaatca ttagtttctg actctgcttc cgttgtgtct ttgcttctgc tattttgtct 721 ctgtgcttct cgcttgggat ttagctctca acttctctca cactggttct atttatcttt 781 gtttacctct ctccatctcc atcactccca gccttcctct ctgcctttgt gtagccttgt 841 tttgctcttg ggtggaggtc ttgactagaa gcctgctgcc cttttcttgg gtgtgaaacg 901 tcccctgtcc atttgtctaa tttaatcaag cccatcaata cacctggaga tcaggcaggc 961 atgacctttg ggctttgtgg acagctactg aggtaagggt ctctccccct caaaagtggt 1021 gctttgttca ggaggcatga tgggtcctca gtacccagcc tcctcctacc tcttgacttt 1081 ctcttcaaaa gccttcaaag ctggagtctg tcctcctaag aaatctgccc agtgccttag 1141 atacaagaaa cctgagtgcc agagtgactg gcagtgtcca gggaagaaga gatgttgtcc 1201 tgacacttgt ggcatcaaat gcctggatcc tgttgacacc ccaaacccaa gtaagcaggt 1261 cggggaactg ggtagagaga tagcctgggg acacagcatt agagggacgg aactgggtga 1321 tgggtcctgc caggcctcct tgtcaatgcc gtagtgagtc acagtgccct aagagaagta 1381 gccagctggt gaagcagcgg gcatttagat agccaggtag ttggaagcct cccacctagt 1441 cagcactggg cggctggcac ctgcataatg gggggcctga agttctagga gagccaggtg 1501 ctatgtttgg gggccgcctt agggagaagg tggtggtgat agaggtgggg aggggatgat 1561 cccccctgct gaagctggac gaggggctca ctctaaaaag tggggatggg aggggttgta 1621 taaagtacaa ggcctctgac cggtagcctc actctcaccc aacccagcaa ggaggaagcc 1681 tgggaagtgc ccagtgactt atggccaatg tttgatgctt aaccccccca atttctgtga 1741 gatggatggc cagtgcaagc gtgacttgaa gtgttgcatg ggcatgtgtg ggaaatcctg 1801 cgtttcccct gtgaaaggta agcaggggac gagggcacac tgagctccct cagccctctc 1861 agcctcaacc ctctggaggc ccaggcatat gggcaggggg actcctgaac cctactccaa 1921 gcacagcctc tgtctgactc ccttgtcctt caagagaact gttctccagg tctcagggcc 1981 aggatttcca taggagtcgc ctgtggcttt gattctattc tagtgtctct gggtgggggt 2041 cctgggcaag tgtctttctg agtctagttt ctttatcggt aaaatgtaca taatgagatg 2101 aaagtgctct gcaaagacct atgtgcacta agaattatta ttcaggtgtt tccatcatgt 2161 tttctgaggt gaaatcacaa aggatcagtg gagtttgagg attatctagt tcaatgcttt 2221 gagtttagag ttttacgtga aaatgagact tgtctcctga cactaagtct ctctcaacta 2281 tagcgctatc ttgctatttt ctctatctca gaaggatcct tgggcaggag gaaggatgtg 2341 gatatatgat ttggctggtt tctatgctga agctctgatc tgattttctc tcacagcttg 2401 attcctgcca tatggaggag gctctggagt cctgctctgt gtggtccagg tcctttccac 2461 cctgagactt ggctccacca ctgatatcct cctttgggga aaggcttggc acacagcagg 2521 ctttcaagaa gtgccagttg atcgaatgaa taaataaacg agcctatttc tctttgcaca 2581 tcctgcttct gtgattcgtt ggggggatga gtggggtggg acgtgtgagg gaagatctag 2641 tatgaggcct ccttcct //