LOCUS HUMPALC 7619 bp DNA PRI 02-MAY-1996 DEFINITION Human serum prealbumin gene, complete cds. ACCESSION M11518 NID g189585 KEYWORDS albumin; serum prealbumin. SOURCE Homo sapiens (clone: lambda-HPA1.) (tissue library: T.Maniatas) foetus liver DNA. ORGANISM Homo sapiens Eukaryotae; mitochondrial eukaryotes; Metazoa; Chordata; Vertebrata; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 7619; 1 to 7619) AUTHORS Sasaki,H., Yoshioka,N., Takagi,Y. and Sakaki,Y. TITLE Structure of the chromosomal gene for human serum prealbumin JOURNAL Gene 37 (1-3), 191-197 (1985) MEDLINE 86031352 COMMENT [Unpublished (1986) Kyushu U., Maidashi, Fukuoka 812, Japan.] revision of [1]. Draft entry and printed copy of corrected sequence in [1] kindly provided by H.Sasaki and Y.Sakaki, 05-MAR-1986. Sequence in [1] has been revised according to corrections noted in [Unpublished (1986) Kyushu U., Maidashi, Fukuoka 812, Japan.]. FEATURES Location/Qualifiers source 1..7619 /organism="Homo sapiens" /db_xref="taxon:9606" /clone="lambda-HPA1." /dev_stage="foetus" /tissue_type="liver" /tissue_lib="T.Maniatas" /map="18q11.2-q12.1" exon 582..676 /gene="TTR" /note="G00-119-471" /number=1 gene 582..7518 /gene="TTR" CDS join(608..676,1601..1731,3824..3959,7272..7379) /gene="TTR" /codon_start=1 /db_xref="GDB:G00-119-471" /product="prealbumin" /db_xref="PID:g386998" /translation="MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVPGSP AINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKAL GISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE" sig_peptide 608..667 /gene="TTR" /note="G00-119-471" mat_peptide join(668..676,1601..1731,3824..3959,7272..7376) /gene="TTR" /note="G00-119-471" /product="prealbumin" intron 677..1600 /gene="TTR" /note="G00-119-471" /number=1 exon 1601..1731 /gene="TTR" /note="G00-119-471" /number=2 intron 1732..3823 /gene="TTR" /note="G00-119-471" /number=2 repeat_region 3279..3286 /note="5' insertion target sequence" /rpt_type=direct repeat_region 3287..3580 /rpt_family="Alu" old_sequence 3297..3299 /gene="TTR" /citation=[1] repeat_region 3581..3588 /note="3' insertion target sequence" /rpt_type=direct old_sequence 3636..3638 /gene="TTR" /citation=[1] exon 3824..3959 /gene="TTR" /note="G00-119-471" /number=3 intron 3960..7271 /gene="TTR" /note="G00-119-471" /number=3 old_sequence 5164..5166 /gene="TTR" /citation=[1] old_sequence 5390..5392 /gene="TTR" /citation=[1] repeat_region complement(5737..5746) /note="3' insertion target sequence" /rpt_type=direct repeat_region complement(5747..6047) /rpt_family="Alu" old_sequence 5780 /gene="TTR" /citation=[1] old_sequence 5907..5909 /gene="TTR" /citation=[1] repeat_region complement(6048..6057) /note="5' insertion target sequence" /rpt_type=direct old_sequence 6206..6208 /gene="TTR" /citation=[1] old_sequence 7185 /gene="TTR" /citation=[1] exon 7272..7518 /gene="TTR" /note="G00-119-471" /number=4 old_sequence 7527..7530 /citation=[1] BASE COUNT 2234 a 1609 c 1544 g 2232 t ORIGIN 1 bp upstream of HindIII site; chromosome 18q11.2-q12.1. 1 aagcttccaa atgacttagt ttggctaaaa tgtaggcttt taaaaatgtg agcactgcca 61 agggtttttc cttgttgacc catggatcca tcaagtgcaa acattttcta atgcactata 121 tttaagcctg tgcagctaga tgtcattcaa catgaaatac attattacaa cttgcatctg 181 tctaaaatct tgcatctaaa atgagagaca aaaaatctat aaaaatggaa aacatgcata 241 gaaatatgtg agggaggaaa aaattacccc caagaatgtt agtgcacgca gtcacacagg 301 gagaagacta tttttgtttt gttttgattg ttttgttttg ttttggttgt tttgttttgg 361 tgacctaact ggtcaaatga cctattaaga atatttcata gaacgaatgt tccgatgctc 421 taatctctct agacaaggtt catatttgta tgggttactt attctctctt tgttgactaa 481 gtcaataatc agaatcagca ggtttgcagt cagattggca gggataagca gcctagctca 541 ggagaagtga gtataaaagc cccaggctgg gagcagccat cacagaagtc cactcattct 601 tggcaggatg gcttctcatc gtctgctcct cctctgcctt gctggactgg tatttgtgtc 661 tgaggctggc cctacggtga gtgtttctgt gacatcccat tcctacattt aagattcacg 721 ctaaatgaag tagaagtgac tccttccagc tttgccaacc agcttttatt actagggcaa 781 gggtacccag catctatttt taatataatt aattcaaact tcaaaaagaa tgaagttcca 841 ctgagcttac tgagctggga cttgaactct gagcattcta cctcattgct ttggtgcatt 901 aggtttgtaa tatctggtac ctctgtttcc tcagatagat gatagaaata aagatatgat 961 attaaggaag ctgttaatac tgaattttca gaaaagtatc cctccataaa atgtatttgg 1021 gggacaaact gcaggagatt atattctggc cctatagtta ttcaaaacgt atttattgat 1081 taatctttaa aaggcttagt gaacaatatt ctagtcagat atctaattct taaatcctct 1141 agaagaatta actaatacta taaaatgggt ctggatgtag ttctgacatt attttataac 1201 aactggtaag agggagttac tatagcaaca actaaaatga tctcaggaaa acctgtttgg 1261 ccctatgtat ggtacattac atcttttcag taattccact caaatggaga cttttaacaa 1321 agcaactgtt ctcaggggac ctattttctc ccttaaaatt cattatacac atccctggtt 1381 gatagcagtg tgtctggagg cagaaaccat tcttgctttg gaaacaatta cgtctgtgtt 1441 atactgagta gggaagctca ttaattgtcg acacttacgt tcctgataat gggatcagtg 1501 tgtaattctt gtttcgctcc agatttctaa taccacaaag aataaatcct ttcactctga 1561 tcaattttgt taacttctca cgtgtcttct ctacacccag ggcaccggtg aatccaagtg 1621 tcctctgatg gtcaaagttc tagatgctgt cccaggcagt cctgccatca atgtggccgt 1681 gcatgtgttc agaaaggctg ctgatgacac ctgggagcca tttgcctctg ggtaagttgc 1741 caaagaaccc tcccacagga cttggtttta tcttcccgtt tgcccctcac ttggtagaga 1801 gaggctcaca tcatctgcta aagaatttac aagtagattg aaaaacgtag gcagaggtca 1861 agtatgccct ctgaaggatg ccctcttttt gttttgctta gctaggaagt gaccaggaac 1921 ctgagcatca tttaggggca gacagtagag aaaagaagga atcagaactc ctctcctcta 1981 gctgtggttt gcaacccttt tgggtcacag aacactttat gtaggtgatg aaaagtaaac 2041 attctatgcc cagaaaaaat gcacagatac acacacatac aaaatcatat atgtgatttt 2101 aggagtttca cagattccct ggtgtccctg ggtaacacca aagctaagtg tccttgtctt 2161 agaattttag gaaaaggtat aatgtgtatt aacccattaa caaaaggaaa ggaattcaga 2221 aatattatta accaggcatc tgtctgtagt taatatggat cacccaaaac ccaaggcttt 2281 tgcctaatga acactttggg gcacctactg tgtgcaaggc tgggggctgt caagctcagt 2341 taaaaaaaaa aagatagaag agatggatcc atgaggcaaa gtacagcccc aggctaatcc 2401 cacgatcacc cgacttcatg tgcaagagtg gcttctcacc ttcattagcc agttcacaat 2461 tttcatggag tttttctacc tgcactagca aaaacttcaa ggaaaataca tattaataaa 2521 tctaagcaaa gtgaccggaa gacagagcaa tcaggagacc ctttgcatcc agcagaagag 2581 gaactgctaa gtatttacat ctccacagag aagaatttct gttgggtttt aattgaaccc 2641 caagaaccac atgattcttc aaccattatt gggaagatca ttttcttagg tctggtttta 2701 actggctttt tatttgggaa ttcatttatg tttatataaa atgccaagca taacatgaaa 2761 agtggttaca ggactattct aagggagaga cagaatggac accaaaaata ttccaatgtt 2821 cttgtgaatc ttttccttgc accaggacaa aaaaaaaaag aagtgaaaag aagaaaggag 2881 gaggggcata atcagagtca gtaaagacaa ctgctatttt tatctatcgt agctgttgca 2941 gtcaaatggg aagcaatttc caacattcaa ctatggagct ggtacttaca tggaaataga 3001 agttgcctag tgtttgttgc tggcaaagag ttatcagaga ggttaaatat ataaaaggga 3061 aaagagtcag atacaggttc ttcttcctac tttaggtttt ccactgtgtg tgcaaatgat 3121 actccctggt ggtgtgcaga tgcctcaaag ctatcctcac accacaaggg agaggagcga 3181 gatcctgctg tcctggagaa gtgcagagtt agaacagctg tggccacttg catccaatca 3241 tcaatcttga atcacaggga ctctttctta agtaaacatt atacctggcc gggcacggtg 3301 gctcacgcct gtaatcccag cactttggga tgccaaagtg ggcatatcat ctgaggtcag 3361 gagttcaaga ccagcctggc caacatggca aaactccgtc tttatgaaaa atacaaaaat 3421 tagccaggca tggtggcagg cgcctgtaat cccagctaat tgggaggctg aggctggaga 3481 atcccttgaa tctaggaggc agaggttgca gtgagctgag atcgtgccat tgcatccagc 3541 ctgggtgaca agagtaaaac tctgtctcaa aaaaaaaaaa ttatacctac attctcttct 3601 tatcagagaa aaaaatctac agtgagcttt tcaaaaagtt tttacaaact ttttgccatt 3661 taatttcagt taggagtttt ccctacttct gacttagttg aggggaaatg ttcataacat 3721 gtttataaca tgtttatgtg tgttagttgg tgggggtgta ttactttgcc atgccatttg 3781 tttcctccat gcgtaactta atccagactt tcacacctta taggaaaacc agtgagtctg 3841 gagagctgca tgggctcaca actgaggagg aatttgtaga agggatatac aaagtggaaa 3901 tagacaccaa atcttactgg aaggcacttg gcatctcccc attccatgag catgcagagg 3961 tgagtataca gaccttcgag ggttgttttg gttttggttt ttgcttttgg cattccagga 4021 aatgcacagt tttactcagt gtaccacaga aatgtcctaa ggaaggtgat gaatgaccaa 4081 aggttccctt tcctattata caagaaaaaa ttcacaacac tctgagaagc aaatttcttt 4141 ttgactttga tgaaaatcca cttagtaaca tgacttgaac ttacatgaaa ctactcatag 4201 tctattcatt ccactttata tgaatattga tgtatctgct gttgaaataa tagtttatga 4261 ggcagccctc cagaccccac gtagagtgta tgtaacaaga gatgcaccat tttatttctc 4321 gaaaacccgt aacattcttc attccaaaac acatctggct tctcggaggt ctggacaagt 4381 gattcttggc aacacatacc tatagagaca ataaaatcaa agtaataatg gcaacacaat 4441 agataacatt taccaagcat acaccatgtg gcagacacaa ttataagtgt tttccatatt 4501 taacctactt aatcctcagg aataagccac tgaggtcagt cctattatta tccccatctt 4561 atagatgaag aaaatgaggc accaggaagt caaataactt gtcaaaggtc acaagactag 4621 gaaatacaca agtagaaatg tttacaatta aggcccaggc tgggtttgcc ctcagttctg 4681 ctatgcctcg cattatgccc caggaaactt tttcccttgt gaaagccaag cttaaaaaaa 4741 gaaaagccac atttgtaacg tgctctgttc ccctgcctat ggtgaggatc ttcaaacagt 4801 tatacatgga cccagtcccc ctgccttctc cttaatttct taagtcattt gaaacagatg 4861 gctgtcatgg aaatagaatc cagacatgtt ggtcagagtt aaagatcaac taattccatc 4921 aaaaatagct cggcatgaaa gggaactatt ctctggctta gtcatggatg agactttcaa 4981 ttgctataaa gtggttcctt tattagacaa tgttaccagg gaaacaacag gggtttgttt 5041 gacttctggg gcccacaagt caacaagaga gccccatcta ccaaggagca tgtccctgac 5101 tacccctcag ccagcagcaa gacatggacc ccagtcaggg caggagcagg gtttcggcgg 5161 cgcccagcac aagacattgc ccctagagtc tcagccccta acctcgagta atagatctgc 5221 ctacctgaga ctgttgtttg cccaagagct gggtctcagc ctgatgggaa ccatataaaa 5281 aggttcactg acatactgcc cacatgttgt tctctttcat tagatcttag cttccttgtc 5341 tgctcttcat tcttgcagta ttcattcaac aaacattaaa aaaaaaaaaa agcattctat 5401 gtgtggaaca ctctgctaga tgctgtggat ttagaaatga aaatacatcc cgacccttgg 5461 aatggaaggg aaaggactga agtaagacag attaagcagg accgtcagcc cagcttgaag 5521 cccagataaa tacggagaac aagagagagc gagtagtgag agatgagtcc caatgcctca 5581 ctttggtgac gggtgcgtgg tgggcttcat gcaccttctt ctgataaatg cctccttcag 5641 aactggtcaa ctctaccttg gccagtgacc caggtggtca tagtagattt accaagggaa 5701 aatggaaact tgtattagga gctcttaggc ctcttcactt catggatttt tttttccttt 5761 ttttttgaga tggagttttg ccctgtcacc caggctggaa tgcagtggtg caatctcagc 5821 tcactgcaac ctccgcctcc caggttcaag caattctcct gcctcagcct cccgagtagc 5881 tgggactaca ggtgtgcgcc accacaccag gctaattttt gtattttttg taaagacagg 5941 ttttcaccac gttggccagg ctggtctgaa ctccagacct caggtgattc acctgtctca 6001 gcctcccaaa gtgctgggat tacaggtgtg agccaccgtg cccggctact tcatggattt 6061 ttgattacag attatgcctc ttacaatttt taagaagaat caagtgggct gaaggtcaat 6121 gtcaccataa gacaaaagac atttttatta gttgattcta gggaattggc cttaagggga 6181 gccctttctt cctaagagat tcttaggtga ttctcacttc ctcttgcccc agtattattt 6241 ttgtttttgg tatggctcac tcagatcctt ttttcctcct atccctaagt aatccgggtt 6301 tctttttccc atatttagaa caaaatgtat ttatgcagag tgtgtccaaa cctcaaccca 6361 aggcctgtat acaaaataaa tcaaattaaa cacatcttta ctgtcttcta cctctttcct 6421 gacctcaata tatcccaact tgcctcactc tgagaaccaa ggctgtccca gcacctgagt 6481 cgcagatatt ctactgattt gacagaactg tgtgactatc tggaacagca ttttgatcca 6541 caatttgccc agttacaaag cttaaatgag ctctagtgca tgcatatata tttcaaaatt 6601 ccaccatgat cttccacact ctgtattgta aatagagccc tgtaatgctt ttacttcgta 6661 tttcattgct tgttatacat aaaaatatac ttttcttctt catgttagaa aatgcaaaga 6721 ataggagggt gggggaatct ctgggcttgg agacaggaga cttgccttcc tactatggtt 6781 ccatcagaat gtagactggg acaatacaat aattcaagtc tggtttgctc atctgtaaat 6841 tgggaagaat gtttccagct ccagaatgct aaatctctaa gtctgtggtt ggcagccact 6901 attgcagcag ctcttcaatg actcaatgca gttttgcatt ctccctacct tttttttcta 6961 aaaccaataa aatagataca gcctttaggc tttctgggat ttcccttagt caagctaggg 7021 tcatcctgac tttcggcgtg aatttgcaaa acaagacctg actctgtact cctgctctaa 7081 ggactgtgca tggttccaaa ggcttagctt gccagcatat ttgagctttt tccttctgtt 7141 caaactgttc caaaatataa aagaataaaa ttaattaagt tggcactgga cttccggtgg 7201 tcagtcatgt gtgtcatctg tcacgttttt cgggctctgg tggaaatgga tctgtctgtc 7261 ttctctcata ggtggtattc acagccaacg actccggccc ccgccgctac accattgccg 7321 ccctgctgag cccctactcc tattccacca cggctgtcgt caccaatccc aaggaatgag 7381 ggacttctcc tccagtggac ctgaaggacg agggatggga tttcatgtaa ccaagagtat 7441 tccattttta ctaaagcagt gttttcacct catatgctat gttagaagtc caggcagaga 7501 caataaaaca ttcctgtgaa aggcactttt cattccactt taacttgatt ttttaaattc 7561 ccttattgtc ccttccaaaa aaaagagaat caaaatttta caaagaatca aaggaattc //