LOCUS HUMRCP 23822 bp DNA PRI 30-MAY-1997 DEFINITION Human gene for ryudocan core protein, exon1-5, complete cds. ACCESSION D79206 NID g1359444 KEYWORDS ryudocan core protein; heparan sulfate proteoglycan; syndecan-4. SOURCE Homo sapiens placenta DNA, clone_lib:lambda DASHII. ORGANISM Homo sapiens Eukaryotae; mitochondrial eukaryotes; Metazoa; Chordata; Vertebrata; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 23822) AUTHORS Kojima,T. TITLE Direct Submission JOURNAL Submitted (09-DEC-1995) to the DDBJ/EMBL/GenBank databases. Tetsuhito Kojima, Nagoya University School of Medicine, First Dept. of Internal Medicine; 65 Tsurumai, Showa-ku, Nagoya, Aichi 466, Japan (Tel:052-741-2111(ex.2203), Fax:052-744-2157) REFERENCE 2 (bases 1 to 23822) AUTHORS Kojima,T. JOURNAL Unpublished (1996) REFERENCE 3 (sites) AUTHORS Takagi,A., Kojima,T., Tsuzuki,S., Katsumi,A., Yamazaki,T., Sugiura,I., Hamaguchi,M. and Saito,H. TITLE Structural organization and promoter activity of the human ryudocan gene JOURNAL J. Biochem. 119 (5), 979-984 (1996) MEDLINE 96390006 FEATURES Location/Qualifiers source 1..23822 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="20" /clone_lib="lambda DASHII" /map="20q12" /tissue_type="placenta" protein_bind 5..9 /bound_moiety="LBP-1" misc_feature 10..15 /note="E-alpha H box" protein_bind 68..72 /bound_moiety="LBP-1" protein_bind 103..108 /bound_moiety="SP1" protein_bind 108..113 /bound_moiety="H4TF-2" protein_bind 116..124 /bound_moiety="NF-kB" protein_bind 129..136 /bound_moiety="AP-2" protein_bind 133..138 /bound_moiety="SP1" protein_bind 148..155 /bound_moiety="AP-2" protein_bind 165..169 /bound_moiety="LBP-1" protein_bind 169..177 /bound_moiety="NF-kB" protein_bind 178..183 /bound_moiety="SP1" protein_bind 189..194 /bound_moiety="SP1" protein_bind 197..202 /bound_moiety="SP1" protein_bind 203..208 /bound_moiety="SP1" protein_bind 212..221 /note="GC-BOX" /bound_moiety="SP1" TATA_signal 234..240 /note="TATA box like (TATAGAA)" protein_bind 253..262 /bound_moiety="AP-2" misc_feature 261 /note="Cap site" exon 261..363 /number=1 CDS join(304..363,12753..12891,15607..15653,18112..18310, 21260..21411) /codon_start=1 /product="ryudocan core protein" /db_xref="PID:d1020390" /db_xref="PID:g1944492" /translation="MAPARLFALLLFFVGGVAESIRETEVIDPQDLLEGRYFSGALPD DEDVVGPGQESDDFELSGSGDLDDLEDSMIGPEVVHPLVPLDNHIPERAGSGSQVPTE PKKLEENEVIPKRISPVEESEDVSNKVSMSSTVQGSNIFERTEVLAALIVGGIVGILF AVFLILLLMYRMKKKDEGSYDLGKKPIYKKAPTNEFYA" exon 12753..12891 /number=2 exon 15607..15653 /number=3 exon 18112..18310 /number=4 exon 21260..23384 /number=5 polyA_signal 22555..22560 polyA_signal 22563..22568 polyA_signal 23365..23370 BASE COUNT 5548 a 5624 c 6307 g 6343 t ORIGIN 1 gatctctggg gacctgcctg gcagtgggtc aaataaataa agggagttgg agctcccgga 61 gggtaggact aggggttgag taggagccgg cgggctcggg cagggcgggt cccttggggt 121 ttccaactcc gcgggcggcg cagtgccccg caggcctcgc ttccactggg gaattccggg 181 cggggtgcgg gcggcggggc gggggcgggc cggggcgggg ccggtaggcc gcctataaga 241 tgggtggcgc gcccgcccgg gccactcgcc gcagcctgcg cgccttctcc agtccgcggt 301 gccatggccc ccgcccgtct gttcgcgctg ctgctgttct tcgtaggcgg agtcgccgag 361 tcggtgggtg cttggaggtt cccgggctgg gggcgaagcg ggggcgcagg ccggtgcctc 421 ctttgttcgt cggagcgtgg gatggggggg tcagatcggg ggtacgctac ccccaaccgt 481 acaccgaggc ccgggaaact ttgttggaaa ctttgctccg gggtcacggg ccagctccgg 541 gatggcttca cgcgccgtgc gcccctcgcc tgttgctctt cccgcctccc cgggcctcag 601 ccccgccgcg ggctacgggc tcgttagtga ctaagccggt gtcaactctt caactcccac 661 accctcgtcc cttccctggt gaccctgggg caggcttgga gcgctgaatc ccctcctcgc 721 tctcggggcg cccagagcag acagctttag gatccgagat ggccctgggg gtcggggggc 781 tgcgtgtact cggaaggggg agggttttag ggttgtgcga ggccctcttt cacacaccaa 841 ggagaactga gccctaacct cagttctggc cccagctctg tcattgactt gtgacttagg 901 gcaaaagtcc tgcccttctg aatctcttcc caatactgca ccaagggtct gagggaatgg 961 ggcaagaggg gacactgcgt tagggtttct agaaagttgg ggactctgct cttttcgagg 1021 acagaggaga ggaatggttt agactcaaca cttagccagg agctgagcct ctgctttctg 1081 caagaagtgt gttcattttt tctcaattgc agataagaaa attgaagcat ccaccttgag 1141 tgaggtgaag ggggtagggg ggagagaagg cctcaatcag cccagggaaa cctttccttc 1201 tcactgtcca ctggcctccg tcatagctgt ccctgggcca gcagaagctc tatccatgcc 1261 cgcagccggc ttaggaggag gggggcaatc tcatctggga agttgggggg catgggaatt 1321 actggtgaag gcaatctgtc ccccacagcc tgagctttgt gccccctttg tgccctttag 1381 ccccagtttt cagagcgagt gagtccttgc agtttaacca ttaatgttaa tttctttgaa 1441 agccttgggg ctcctgttcc tctgaattta cttagcggaa ggttgattct gcctgcaggc 1501 tcttcttgag gaatgaatga gaccctaggc aatacttcca gcacaattcc aggcatgcca 1561 tgatgattgc aaacgtggag cgcctttgtc ggggggccag acattgctct aataactttc 1621 taatgggtat atcaaggagc ttaattccaa caacaatctg actgtgtact gttcttaaac 1681 tggtcctgag gctagagagg ttaagtaact tgcccagggt cacacagtta atacacaata 1741 aatgggtgag tcagattgaa atttaggcag ccaggctttc aagtttctgc tttagcttaa 1801 cttctactct ttgtgctact ccaggtgtcc catcgttggt aactaaagac gggtttagaa 1861 taggttgaga ttttatgctg gaaggcaaag gaattctgag gtggaaggaa acaaggccag 1921 agtgaggtga tgacttaacc taaaccaaag gctaccttgc ctaaaatgtt agtggctgag 1981 gacccaagcc ttctgcctct agcacagtgc tctaaactag gccctgaagg atgtgtcggg 2041 tcaagcaact ggggaagcat ccgaaggata ccacctaggc agtacaggga aaaagaggaa 2101 aggacccagg aggttgctga ggtcaccgtg tgcccagtca catgccagtt tcctccaggg 2161 ctgctgagcc ttcaggtgct tcagggtgct gagctgtcag ctgtgtcctg ggggcattct 2221 gaaggatgta gtttggggga aggggactgt gtcagtcctg cctgggtgac ccatcagctg 2281 caggagacat cagccctggg cagctgcttc ctgagatagg tgtcaagtct catcctgacc 2341 tcagctctcc ccttcctggc taatgtcaca gacctcctgc ctgtaactgg ggcacagggc 2401 ttcccctttg gcctgtcccc tccctctttt ctagattgtg gttggaaaaa tcagacatag 2461 tcacggttgg ctcggactga agagatgatc cagcgtgtcc ttttcttttt gcaggtagag 2521 aaaagtgagg cccagggaga aggactttgc taatagcagt taggagtgat agagtacttt 2581 ttatatgaca gatctggtgc attttgtcct cacaaaaaga cctgtcacat ggggattcta 2641 ttatgcccac tttccaaatg tgagaggtaa aatggtacta ctttgggtta gtagagggca 2701 tccaggaccc caggatctct gactagtagc cctcccattg tgggtggtgt tcgcccgact 2761 gttccatcat tccccttacc acccccatat tttggaaggg aacccaggct cagtacccag 2821 ctgtcctctc ctctgtttgg ctgggcttgc tatactaaac cagttcttcc tgtccagctg 2881 ggagcattcc ctgatctgcc ttcctgccac tccctctcag gccaattaaa ggcagccttg 2941 ttttgggagt cccctccacc caaaggtgtt cctacccagg ggcacagcct actgacttgg 3001 ccccaggcca ggcggttgtg gggaagtgtc ccccacctat cacctatcaa gtgtacttta 3061 gcttaaggac atttctggtc ttctacagcg tcctcttctt gattacatgg gagtaggggt 3121 gggggcggaa cgtaggggct tctaggaccc ttgagtgaac agtgagagct cttgggactt 3181 cttgagccca gggagttatc aaacacccca gaaaatattt gggccatgat ttggagggtt 3241 ccgtgagttg gggggaggcc tctttccccg ctgggctgac atcccccacc ttaaaatgaa 3301 aggtttgaac agggtagcct ccagagtcct ttccatctct caatttgatt aataacttaa 3361 gtacctacta ttcaaaagag gtctctctct tgaaggaatt aacttgaggg aattaacata 3421 ctccaccaaa tgctgaatcc ctccctctct ccccccgcac accgagggca ggaactctgc 3481 tctatttgtt tttgtgaaat acctgtcccc tagtttgtac tcaggaaatg cttgtatgaa 3541 tgaataaatt cgtgcatgta actttattct aaatggttca ttaatgttat ttattgctag 3601 tatgagtatc tcccagtact gcgaggtacc attttctcta tttttacagg aaattgatgc 3661 tcggaacaat gcagtggctt cctaaggtca gaaccaggtc cttctgatag ggcaaggtgt 3721 ctggtttgag tgtcctcaga atattccaga tgaggaaatt tcgctgggtt tgaaggtaga 3781 taccttaggt cctacttctg cgttgctggg tgaccttgag caaacatgcc ctgtctctgg 3841 gtctcagtgt ccccaactct aaaataagga ggctggacca ttgccttcca agggtccttc 3901 ctgcccagag agcccattga tgaggggagg ggccctttgc tggcctcctt ggtgaagagt 3961 ctaaacaaat cccagtctca gaagagaagt tggggtggcg gggggacatt cagctcctgc 4021 catccccagc tcctagaaac agagggcttt tccaaggact tggagtgctg agcctgcctg 4081 aatgaggagc tggggaagcc aggctgggct cccagcccag ctccctgttg ggagaaattg 4141 gctcctagct gtccttcaac ctcccggact ggacaggcga gtgtgatttc caaatgaatg 4201 cttaaaattg gggtaagggg ctggaccgag cgctgtgagt cactgcatgc tagcgtagcc 4261 tgcctgagtc acccatttcc tttcaaactc ttggctaata ggacagctct gtggtggggg 4321 gtgttggaat gagctcagag ttttaccttg tcctttggga gtcactgttt cagtgtccgg 4381 ggcctcgagg ggacatacag gacatgtttg tactaggtcc cgccactttc acagcccctt 4441 gcctgcatgt agactttgac attgtacatt gtgcagccag tcctcaaaat tgggctttag 4501 acctctgcag agcaggtagt acttttttcc tctttaaggc aaaactgagg ctgcaactgg 4561 cctgcatttt ttcagagagc aaaagctggt actgttcagg tttggtgtga ccccaggatt 4621 ttctgatgtt tgtgaggact cgtctttgct tcctggggct ggccagaggg cattgaaaca 4681 ttggcttggt gttacacaga cttaactcca gacgtgcgaa gtccacctct tactggctac 4741 atgaattcag tcatgctact ccacctctga gccccagcct cctggtctgt taagaagatc 4801 atgataccgg tgtggcgaag cttaaaggag acgacagggc tgtaaataaa ggcacctagt 4861 accatgcctg gtagggagga ggtgttactt agtgacagtt cccttccttg cccaggccac 4921 cttcatgcca gggggtccta tctctgaaga ttctgagccc aggtctcctg gaaagctttc 4981 tccatccccc ttatccccct tatctacccc cacagctggg aggtgggaag ggagaaatct 5041 agggtggggc ttttggagtc caaatctcct atttgtttat cttagaagtg ggctgtttgc 5101 taattatcga atgggtttat gtttaaacaa gaaccagttc tgggcagccc cacctctcct 5161 gctgggattt gctggagcct catgctgaac agtttgcagc ctggagggag agggggcagg 5221 gggtttgcca agggtatcag accactctgg acactgtcca ggacctgggg tcaccctcct 5281 gtgctggagg ggcagagttt ctacccttaa ggaggctgag tgattgcaaa tagcactttg 5341 aggggtgggg tgttggtgga cagaaaaggt acagtgttct gaaaagccag tttctcgtat 5401 gttttcactg catggtgccc tagagaggga ggagagagaa cacatatgtc aacagttggg 5461 gtctcattta accttagaag aataagcctg acttcttggg cttgtttgtc attaactaac 5521 acagtggtga ccttgggcac attcttgcat ctcactgggg cctctctggt cccatctgct 5581 gaaggctggg tgactgaaaa agagggtaca gaaaactcca gcccccgtcc tagctctgct 5641 gctcacccag ggacacacac agttaatacg tcactttgtt gatgtgaact ccagtgtcct 5701 ctataaaaca cctgtggcac tcaaaggtca tcatcgctgt ttggcaaact tgtaaagttc 5761 tggctttatt agcacctaga caagggttct tcacccggcc agagtttggc tttggggagg 5821 tggtgtctgt gcatatgttg aaaatgtaaa ctaagagtta cagttattgg ggtttagacc 5881 tttttatcct tttcaggggg ctgcagtact ccccaaaagg tcactctgat ctcagcagtt 5941 ctttctggct ttgacctttc tacagctatc cttcctccct cccccacttc ccagccttgt 6001 tcttgcctcc tgcttccccc aacccccacc ttcagcccag accttcctat tcagcggccc 6061 ccaccccttc aggctgcatc tcacccctcc ccctgtcctc caggcccggg agctcggctg 6121 ctccagtttt ctctggcaca gtagaagagg ctgctggtca ggtgacacct ggggtaatgg 6181 aaaggggagg cagggagagg ctggtatgtg tggaaacagt gacttggtga agcccagcag 6241 tcagtggcca ggcctgcggg gactggcggt gtcactctag cctctgggcg tgggggcaga 6301 tgtggcacat ggctggcccg gctacccaga gtggggatac tccttgcctt ggagaagccc 6361 tgccggagcc gtctgtggga cagactgacc tggtctggag gatggcttcc ttgggggtcg 6421 gtgagggagg ctgggaagag gcaggaagcc agcacccagg gctgatctaa tcagctgaga 6481 taaggctgca gcgtgggctc tctactctgc tctgagaaca caggaggttt gtttacatcc 6541 cgagagcctc cctagccctc ggatccagca gggatttcgg atctgctgcc tagattacaa 6601 gctccaactt caatgcacct ctgtctctga ggccctgagg gagccagccc cctcctggct 6661 gtctccaccg gtaatcggag caatgcccag cttggttact gggctgggac agagggaggc 6721 ttgtctcttt gagacctgtc ttttacagat tggaaaactg aggctcagag aagggaattg 6781 tccacgatca tccagggagt tagtaacaag ggtgctgggt cagctcctgg cagggagaca 6841 tccagaggct cctgaaccct tcccccattt ctagctggca ccctaggatc ctggagttct 6901 tgctgtggga atgggctgcc ctgaggcttg gtgaaaagct ggttgcaggc agtgcaggcc 6961 tggctctctc ctgagtgatt gtgttcagag taacccgacc ttgaaggcga catttgaacc 7021 ctcactccac ccccaccccc agacctggtt taaccattca ggcaccagag caccagacca 7081 tggattggtg tgtagtttct ttttaccttc tagattttta tttatttatt ttgtccctgg 7141 ggacccaggt ccccaagtag aatttcaggt gtttctggtc actgtcattt gcaccttcgg 7201 ggaaaataaa aatggtcttt acctctgtct gcttaggaca ggtggtcaaa gctgtgtgac 7261 cttgggcagg tctctgacta tctctgtatc tttttttcac agtctgaagg gacctgattg 7321 gttgttgaaa gtctctgggc tcagaagcaa aatgataacc tattatagat tatattcctt 7381 tacagtttgc aaagcaccat ctccctgtcc ccaggctagc ttccttccag caacagaact 7441 gcctctgcaa gttttcccag gcctctgatc ctttgagcac tgatcccact ggccaggagg 7501 aaggcaggta ggggttaatc acagccacta ttcattgatc acgtgctggg tccttgcaca 7561 cacaaatgca ttcctcttaa tcctcatcac cctgcaaggt gctaccagcc ctagtcacaa 7621 aagaggaaac tgaggatttc agagatgaaa taaactccca agctcatata gttaggaagt 7681 ggcagaactc acacttgtga atctgccttg atgcacaacc actctgggtg gtagagtcac 7741 agttgtgggc cccaggtttt agccaggctg gggaatgtct ggcccttaag aagtgggtgg 7801 ggtggggaag aacagttacg agtagtgtac gctgctgggg gtctcctgct agaaatcatt 7861 ctggtgggtc caggtgttgg agccccaggt actcaccatc ccctctcccc actaaatttg 7921 gcttgccagt tattaccctt ctggtcttgc ctcctgaaag aagggtcaag tgtgtccccg 7981 accctacctc ccctgggaga gccaggtcgg gagaggctct cattagttca cagttatcca 8041 agccctgacc ctgaactcct ctctggtgcc ccagccaagt ttctgttcct ttgtttaagt 8101 gatatcactt tcacctttgt ttactcctag gcagggacag ggttgccctg gagccctggc 8161 ccagccagtg tgttgtggac tggcgggtta ggctggagag aagtgaagag tgggtggcag 8221 tgagaagcct agttgtggtt gggacgtgtt cttgaggaag atctggattt gaatcccagc 8281 tctagctttc tagttgcatg acgttggata agtgactcag ctgaacctca gtcttctcat 8341 ctgcaaaatg ggtagagcac cttgcaaggc tgttttgcca tttaaatgaa cttgtataaa 8401 caaagtaccc agcatggtgc ttggcatgta gtggatactc cttttagtca ctcatgcttt 8461 tcctggggtg atagaagcca taggatttgg ggatagggtt gggataggac cttttcgtag 8521 cttcatgcct atagccaaaa gactagatgg ggagtataac tgtaatgaca gctgctgcct 8581 gtggatttgc tgagaccctt aggggcagcc aacaccctgg aaggcgagag aagataattc 8641 cagtctggag ccaggatacc taggttctaa gtccatctcc gctgccagct gcttggatga 8701 ccttggcaaa atcccttgtc ttgtctgttt gctaggttat aaaatcagat accttctgtt 8761 ggcaggtgtt agtttctgta gaacaaaaga gcacttcccc tcccttcttt ctccccaaca 8821 gtctggggaa gaatgtagta tctctaaacc cccaggcact aatcccagat ccccaccagc 8881 cacagggcca gcagagtctg tgggacctag gcccattgcc ctatttttta ttttttggag 8941 acagggtctt cctctgtcac ccaggctgga gtgcagtggc acgatcgtag ctcactgcaa 9001 cctcgacctc ctgggctcaa gtgatcctcc cacttcagcc tcccgagtag ctgggaccac 9061 aggcgtgcac aaccacattt ggctaatttt tgtagagatg gggtttcacc atgttgccca 9121 ggctgatctc aaactcttgg gctcaagtga gcctcccacc ttggcctccc aaaatgttgg 9181 gattaagcca ctgtgcctag ccaccactgt cttacttagt tggtaatttc tgttgtgtgt 9241 tcatgaaagg gacaaagata caaggagact tgagagccca gagagggtgc ctgtgcatgt 9301 atacacacta acacacatgc cttgggcaaa ggtgggtgag ctgaggagaa cagaccacat 9361 tcttagccag gagcagggcg ggtccatctc tggtcagggc tgggcctggc tgctgggtgg 9421 cctggttctt caaagtcacc ccagactcaa tgggctttat ctgaaaagag ggcggaggag 9481 aggaggaccg ttggtgcctt cccaaccttt acacaaaaaa gagtgattgc ccacaatccc 9541 acggggcttg gtcccgtctt gctggcctag tcctaaatgg ctcttatcca ctttggagtt 9601 gccttccctc ttgtcagagg tcatgggtgg agaagggacc aaaacagggc agagaggggg 9661 cttccagagc tcaaggagag atttaattcc ctgtgtcctc ctatcaccac tgggagctgg 9721 aagaagtttc tttccagccc cttgacttgc tgtaggaggg aaatcctggg ctcatctaaa 9781 tgcagccttt gaagactcca tcttttcaga gctttgaaat aggatcgaat ccaggccgtg 9841 ccgcggagcc ccggggtgac ttcagactag actagtttct tttttggaaa ctgagtataa 9901 aaatgaaggg ttaaggatga acaggtgccc acaaagaggg ctgaactggg aataaatctt 9961 ggtttcagcc ttggttttgc tgctgacttg gctgcaagat cttcacgccc cactttcgct 10021 catagccttc atttctctaa tgtaaaacgg aggtaattcc taacagccag tgggcatgct 10081 aatcccatgg gttgttttga aatacctctt agcactttca catactgaaa gagaggctgg 10141 atgcataaac aaccttccat ggctcctggg ggcagtgagg ggtgggaaaa ggtctctcag 10201 cctgagacaa gtctcctgat ggaactacag cccctgttga ggactttgac ctggtcaaca 10261 gctggccaaa gtgtaccatt ctttctttct cccggctaga ttgacccccc tacttaacag 10321 ggctcccttg gagctggggc aggctggtga ccccgtgtac atatgtgttc atgcgtgtgt 10381 ttatgtgttt gtggttaaat gtccaggtca gtgaagcctg ggttctggcc cagtgtggct 10441 acttcctgct tgtgtggcct tggacaagtg actttacttt tctgagccct tgtttccatc 10501 tctgcaaaaa gggactatta aaaggaccta gacaggctgt gtgcttggtt aaggcctgtc 10561 acttgggttc ttgggggatt tgccacagga gatggaggta ggagcacagg gaccctgccc 10621 ttaggtatag gcacttgggc agccatgagg agccttcctc ctgctctgcc aaaccaaagc 10681 cacaggcacg ggctatgtgc gggggcttga attccagcac cagcagcccg gcagctcctg 10741 attcccgagt catgaagtca tctctgagca gcacttaacc tctctggctt tccaccccca 10801 cgggtgccaa gcgttcagca ttctccccac tccccgggag agagtgattc ctggccactg 10861 ccttccttgt ggcctgaccc cgctcccttc cgggaatcca gcattctccc tctgtggggg 10921 tggaagaggg tgcatgaggg tcaggttcca cctgcctctc cccagaagcc cagtggggag 10981 agtacaggag tggctctgaa gcagctttcc tgggcctctc ctgcaatgat aataacctta 11041 tcttagggac agatgttcct tctcagacac cctcctttgt caatggcagt ctcagctgag 11101 tgaaggactg cctggggtgt ccgaaacaga gacctgacct ctttctatcc tgagttatgt 11161 agcgaacgct ctgtgtgacc ttgggcaagt ccctcccctg ttccgggctc agattcaagt 11221 tgtgtgaaac gggaggacag gagctccttg ggtcctggca ttctgtgatt ctaagcagac 11281 ccccagctcc tgcagttatg gcgtctggag aagatgggaa tgtctttcag cgggaggggc 11341 atggtgtatt gaacttaatg aaaaacccca actctcctgg caaatactag gcactttagt 11401 gtttgaatta attagtagaa taatgaactt tgctcagagc tgctgttctc tgggcaaaca 11461 gaagcctgag cccagaagct ggaggaaggg tgatgggcat ccaaatgttt cctgtgctct 11521 tgagggtaca ttgttcccac tcggtggagc tacaggatgg gagcagggta actgatgtac 11581 tgtagggctg cccgggacct ttgacacttt cttttggcaa gcggtttggt gggagtggac 11641 ctgagactct gtcctgatca gctgtgtctc cacagggtag tggctgagtg atgattatgg 11701 gtactggagt ggatggtctg tgagggtagg gattgtgcct ctcggtgtct gcatggtgct 11761 ggcagcagag tagatctgtg ggagatgttt ggaaggcaag actgaatcca ggagtacact 11821 cctgagtcat caggtctggg cagcgccctg acctgaggct gtcttagggt gtgcgtgagg 11881 cagccctgtc tgtcccggcc cagactgact cagctgggaa aagtatcctg gactgggcaa 11941 gaccagaacc aggagcccac tccctgtcct gtgtgaatca gctgccactg catcacagag 12001 ccctggagtg tagcatccca gggccctgtg catggagact cctggctctg aagtcaggca 12061 gccctgcgta tgcaatcctc gctcttccat ctgccagctg tgtcaccaaa agaaaatgac 12121 tccctcggct gtaaaaagaa gtgaataaca tgcctccaga gttattaaaa cagggcccag 12181 cacatagcaa gtgctcggta aaggatatct agccatatta ataatttgat tattacctca 12241 tttactgttt ttattttttt tgagacgggg gtcccactct gtagctcagg ctagagtgca 12301 acggcgtgat cctggcttat tgcaacctcc gcctcccggg ttcaagcaat tctcctgtct 12361 cagcctcccg agtagctggg actacaggcg taagccacca cgcccagctg atttttgtat 12421 ttttagtaga gacggggttt caccatgttg gcctggcagg tcttgaactc ctgacctcaa 12481 gtgatctgcc tgcctccgcc tcccaaagtg ttgggattac aggtgtgagc cactgtgccc 12541 agcctcatgt actattttta tttgcccaga atggaaagag acttgcctaa ggacacgcgg 12601 tgagttagag gtagagtggg atccaggacg caggtctcca ggccctggct gtctctttct 12661 agtttctgaa tgcccacttc actagctttt gggcatcagc tgtcatggag cactggggat 12721 gttggctgat gtgtctcctt tctttatctt agatccgaga gactgaggtc atcgaccccc 12781 aggacctcct agaaggccga tacttctccg gagccctacc agacgatgag gatgtagtgg 12841 ggcccgggca ggaatctgat gactttgagc tgtctggctc tggagatctg ggtacggaag 12901 gtgtgctggg caggcgtagg cacaaagctg gagggagtgg tggcttcacc agccaggagg 12961 gtgaccatgc cttgagactt ggatttttgt gggacttttc ctagagtgcc cttcttcttc 13021 cttctcaaaa aaaggggaaa caaaagtaat ggattaacct attccatccc ctgagagccc 13081 ctggggacaa gctgtttgct gctttgaagt cattggtagc tctgggtttt ctgagctcca 13141 gcctgaacgt gtcctcataa gctcttctct tttctgcagg gcatggtggg ggtggggtga 13201 gggtaggatg ggtggcagga cagggtggga gtggggaagg aggacccata gagtgttttc 13261 ctttttttga aaggaaaagt tccaccctgg gccacatggt gagaacttgt ctctacaaaa 13321 acacaaaaat tagctggatg tggtggcatg cacctgtagg agtcccagct acttgggagg 13381 ctgaggtggg acgatccctt gagcctagga ggttggggct gcagtgagcc aagatcatgc 13441 tactgcactc cagcctgggt gacagagtga gaccctgtct caaaacaaaa aaggaaaagt 13501 agcagcttag aagtggggat ggggtgggag ggggcatgag tgggcagaga tgtagttggg 13561 aaaccaagaa caagtccctg cttcagtggg ggtgggggcg ggtgaagggc ccaaggctct 13621 aggccagaca gctaataagt gtccctccta tgtgcagaga ggtgttaatg attgcaagtt 13681 ttagctttgc aagttttagc tttggagtca catggtcctg agttcaagcc tccatcctgt 13741 gtgaactgag cttcagtttt ctaatctgta aaatgggaat aataaagata gtacatcagt 13801 gttgtgggga ctgaactgac ttaaagcttt tggcacctac caagcactca gtacgtgtgt 13861 gtttggttta aaaaaaaaat aaattttatg gccgggcacg gtgctcatgc cgtgaatccc 13921 agcactttgg gaggccaagg caggaggatc acgaggtcag gagtttgaga ccagcctggc 13981 caacatggtg aaaccccgtc tctactaaaa atacaaaaat tagccaggtg tggtgtcgag 14041 tgcctgtaat cccagctact tgggaggctg aggcaggaga attgcttgaa cccgggaggc 14101 agaggttgca gtgagctgag atcacgccat tgcactccag cctggtgaca gagcaagact 14161 ctgtcttgaa aaaaaataaa aataaaaaaa taaatttcat tatgtgcata caacatgata 14221 ttatgggata catatagata gtaaaaatgt tactacagtg gagttaagta atatatccat 14281 catctcacat agtcgcccag gaaatgtttt aatattgcag ttagagtttt ctttctcaaa 14341 agttaattcc ctggggatct tgttaaaatg tagattttgg ccgggcgcgg tggcttacac 14401 ctgtaattga agcactgtgg gaggccaagg caggcggatc acaaggtcaa gagatcgaga 14461 ccatcctggc caaccaacat ggtgaaaccc cgtctctact aaaaatacaa aaatcagctg 14521 ggtgtcatgg tgccaccctg tagtcccagc tactcggggg gctgaggcag gagaatcgct 14581 tgaacccagg aggcagaggt tgcagtgagc cgagatggca ccacggtact ccagcccagg 14641 cgacagagag agactctgtc tcaaaaaaaa aaaagtagat tttgattcag tcagccctga 14701 aattctacat ttcttcttct ttttttttta accaatgaat tatttttact ctttttaaat 14761 aagtgaaata ttagctttaa tgttttctga tcatgacaat atttttagat aagaacattt 14821 taaacattca acagtaagag actattgaaa ataaatgaaa ttcattgaat agaagtaatt 14881 aaaataataa tgtaactctt taagcattgt aatggaaaga tgttaatgat atattgttac 14941 gagcccatta ttgggaaaaa tgtatttagg aatacgtatg gagggaattt atttatttat 15001 ttttttgaga cggagtcttg ttctgtcgcc caggctggag tgcggtggta ccatcttggc 15061 ccactgcaac ctctgccaac cgggttcaaa gtgattctcc tgcctcagcc tcccaagtag 15121 ctgggattac aggcgcgtgc catcacccgt ggataatttt tgtattttca gcagagacgg 15181 ggtttcacta tgttggccag gctggtctcg atctcctgac ctcaagtgat ctgcccgcct 15241 tggcctccca aaatgctggg attacaggcg tgagccaccg cgcctggcct tgaaattcta 15301 catttctaac cagctctcag gtgttgctat tggtttttgg atccacactt tgcagagcaa 15361 gggtttagag cagatgaagc ctctgcccag ctgccagctc acacattcct gtgaaagagc 15421 cagggggtgg gtctgaggag ccccatttta cagatgagat gactgaagta ggggtgggga 15481 agctcgcttg ctggacattg agcatttgga agctggttgt aaggtggagc tcccaccagt 15541 cctggctgaa ggggtcattt tcctggggta atggacctca ctcacacagc tattctgacc 15601 ttacagatga cttggaagac tccatgatcg gccctgaagt tgtccatccc ttggtaagta 15661 gctacatgct tctgcctctt ccactttgct cctctatagc agacctattg ggagaggcag 15721 aaaatacagc ccccataggc agaataagtg aggggtctta ccccactatg cgggaaggct 15781 ttttaaaaat ctggccctgg ggtgggcatg gtggctcagg cctgtaatcc cagcactttg 15841 ggaggcttga ggtcaggagt tcaagaccag cctgggcaac acgatgaaac ctgtctctac 15901 ataaaataca aaaattagcc aggtgtggtg gcatgtgcct gtagtcccag ctacttgaga 15961 ggctgaggtg ggagaatggc ttaagtccag gaggcagagg ttgcagtgag ccaagattgt 16021 gccagtgcac tccagcctgg gtgacagagc cagactgtgt taaaacaaac aaacaaacaa 16081 acaaatctgg ccccaggctc attttgtagg ttgctggtag gccatcctcc ctgcagggat 16141 agtcaccgtc aacaccaact ccttttctct acatttatag ctatttccta gcattgatag 16201 aaaagtatat atataggccg ggcacagtgg ctaatgcctg taatcccagc actttgggag 16261 gctaagacgg gcagatcacc tgaggtcagg agttcgagac cagcctggcc aacatggtga 16321 aaccctatct ctactaaaaa tacaaaaaat tagcctggca cggtggcgtg cgcctgtagt 16381 cccagctact tgattgggag gctgaggtag gaggatcgct tgaacctgag aggcagagat 16441 tgcagtgggc agagattgca ccattgcacc ccagcctggg cgacagagac tccctctcaa 16501 aaaaaaaaaa aaaaagtata tatatataat tctatgaact gcgtttttca cttagactgg 16561 tcatgagtat ttccctgcat aatttaatgc tcttgtcatt tttataggct gcgtaatagt 16621 ttacctgatt ccctttattg acggaaaaat ggcttataat ttgttaacat tttaaaatta 16681 taacactgca gcaaacatct tttttatttt tgcaaagcaa taacaagttt attaagaaag 16741 taaaggaata aaagaatggc tactccatag gtagagcagt ggcattggct gctggttgcc 16801 catttttatg gttatttctt gattatatgt taagcaaggg gtagattatt catgagtttt 16861 ccaacaaagg ggtgggcaat tcccagaact aggggctcct ccccttttta gaccatatag 16921 agtaacttcc tgactttgcc agggcatttg taaattgcca tggcactgat gggagtgtct 16981 cttagcatgc taatgtagta taattagcat ataatgagca gtgagaccaa cagtttcatt 17041 gccatcctgt ttttggtggt ttttggcaag cttctttatt gcaacctgtt ttatcagcaa 17101 ggtctttatg acctgtatct tgtgcagacc tcctatctca ttctgttacg taggatgctt 17161 aacttactgg gaatgcggcc cagcaggtct cagccttatt ttacccagcc cctattcaag 17221 atgtaggcac tctggttcaa acacctgaca ttttccccct cccttttgta agaaaaccct 17281 taatcctaag ggttgcagag ggacaaagat ccatcttcta taacttcttc atgctgaata 17341 gggtgatgat attcctgctt aactattagg gcctcttgta tccatggtag agaggggttc 17401 agtcagaaag ggccagtatg gtgagggcca ttcataactc ttagttctga caaaaggtga 17461 tatccaaagt cctccaatca gtgctgcagt ccatttcctt tgattcggga gtctcctccg 17521 tctcatccct tctgtggttc tccagaaaga tgttaccaga aaggggtccc gatccagacc 17581 ccaagggaga gggttcttgg atcttgcaca aggtagaatt cagggtgagt ccatagagta 17641 aagtgaaagc aagtttatta agacagtaaa ggaataaaag aatggctact tcataggcag 17701 aggagctgca gcaagcatct tttacacgta gtctctgaag agctccttac aatagagttt 17761 ccagggcaaa actgccacct taaagggcaa gcgatgtcta aggttttgcc aaattgcttc 17821 cagagtggtt gctctagaat aaccagtggc cagcagtgca ggagagcacc tgcttccctg 17881 ttcccttggg tgcattcatt tttcatttgg gacagatata ctaaaaaagt tggggataag 17941 gattttggca gcataattgt ggagacagtg ttgccaattc ctgctccagg accatatggt 18001 tcagctgaat atggcagaac cagattctct gcctggctga atgtccctgt cccctgccct 18061 gagtctcttc caaaatacgc tgagtgtctc ttctcctttc cgcccatcca ggtgcctcta 18121 gataaccata tccctgagag ggcagggtct gggagccaag tccccaccga acccaagaaa 18181 ctagaggaga atgaggttat ccccaagaga atctcacccg ttgaagagag tgaggatgtg 18241 tccaacaagg tgtcaatgtc cagcactgtg cagggcagca acatctttga gagaacggag 18301 gtcctggcag gtaagtccca tgctgcttat aagatgcctt gaaggtggaa tggggctcag 18361 cgggggagag cacctgcagg cagggatgcc tccagccatg aggctccttg gtgccccttc 18421 cttttgccta ttcaggttgc cctagaacat tgaaagacta caccttcctt atggggtggc 18481 tctgactgtg cagcctggtg gagggagagg aaaaagcacc tatcaaagtc ttctggaaaa 18541 taggcaattg agtcattctt ctgccttaag tctttctcat ttattttgca aaggactttc 18601 actgtataag tttggcatct gggagttaat cattaaaagt taatttccct tgtaagtctg 18661 gaggctcctt cgaattgggt tagcttcccc tccccctact ctatcacttg gcagccttgt 18721 gaccttggct gagaagcttt cgaacttgat gagcctcagt ttccttatct gtaaaatggg 18781 tacagtgata ccttctgggg ttgatataat gagtccatga aaaataaaat atgaaataac 18841 tttgcacact ataaagggct attccgattt ggcctcagtt cagagttctt tactggaatg 18901 tgcggtgagg aatgctttgt cccaggtgtt gacaaaaggg atggagggaa ctccccaagg 18961 tcatggccga gggcagcctg gatgaaccgg cctggcaagt gggcaccctg ggcccatgct 19021 gggtaactcc tgtctcctgg gaatcaacag agccagcagc tccaaggagg cttgagctat 19081 agggacagag cctggcttca tccaggacag atggaaggtc tcacctgcct cttgtaaaga 19141 gggttcctgg gagcacagcc cctgatgact gggcccacct cagccctgac cctggcttcc 19201 tggtatctga gccaaagttc tttttacttt tctttcagaa gtaaaaagat ttgcataaga 19261 ctttggattt gcataaggtt ttgctctaat taactaaagg tgctattgct tctaaagaaa 19321 aatttgaaaa ccactgatta atctaagcac ctgcttctta tacatgggga gactgaggcc 19381 caggctttag gccacatagt aagaaaagaa ctgaagccag gttatctctt taatcttcca 19441 tttgagaatt atacaagcct aagagcctca tgtgaaaagt tatattgtta gctggtgtgg 19501 tggaatcccc cattccagaa gctttaatca gcacccagga gccttattaa atgcttgctg 19561 tatgctgtat gattcctgtg cccctgattg agtccgtaca acacaaaact cagtctaaag 19621 aacttatccg aagtcacaaa gctggaagtg gcagacctgg catttggact gaggaccaca 19681 gtcagcttct gagaatgtgc ttgaaacttg accctgtggg gcatcccagc gcagacccag 19741 ggcctcgtgg aggaactggg gtcatcagag ggaaaggtga tagagacaag aatggggttg 19801 atgcctgata ttccatgtgc ttgctctggc acctcctggg ggtacttttt tgttgctttt 19861 tcataggatt ttacccaaga aagaaccttg cttgactcct ctgtgccact ctgtccccat 19921 tgtgtacata gatttgtagt gtgtgcaggg atggaaaatt aatcttctta gcccgagtaa 19981 gaccgaatta gggaactcaa tctgccacag aagggattct atgaagcatc cctgccccta 20041 gcaaacagga atgagtcatt caggccacct ggcagagtgg acaggccaga cccactcact 20101 gttagaagcc catctctgcc caacactagg caggttctcc tctcggagcc tgaaagtatc 20161 atttattaag cacctcctgt tgtgcacacc tgattcaggg ggttcgggac acagatataa 20221 accttaaacc cttacagtta atgaatcttg agaatatgct atgcactagg cattgttcta 20281 agcactttga gtggattaat ttatttaatc cttaggacaa atgtatgaga aaggtatggc 20341 tcttcccatt ttgcggtagg gagatgaagg aaacttgccc caaatcacac agccaggaag 20401 taggagaggt aggagtggaa accaggcctt agctactgag ttctgtatgt aattgtaaca 20461 taagagtttg gaattagtat gttctgcatg tgtgcacttt gaatgtacat acctgtctat 20521 gaagtgtagg ctatataggt aaatatgcac acagggagag ctagagagtg ccctgtgcta 20581 aggactgcag gataaatatg tctacaggga tttccatagc ctacggtttt ctcctgttcc 20641 tggttcagtt agtgctagac tgttgcaggg gagtccgcgt ggtgtttgga aagagcctag 20701 gctttagatt caggcagatg tgggttaaaa tagtggcctt ggccgagtgc ggtggctcac 20761 gcctgtaatc ccagcacttt gggaggccga gatgggcaag gtcaggagtt caagaccagc 20821 ctggccaaca tagtgaaacc ctatctctac taaaaataca aaaattagcc gggcatggtg 20881 gcacgtgcct ataatcccag ctactcagga ggctgaggca ggagaattgc ttgaacctgg 20941 gaggtggagg ttgcagtaag ccgagatcac gccactgcac tcagctcggg caacagagtg 21001 agacttcgtc tcaaaaagaa aaaggagtgg ccttaccact agccctgtgg tcttcagtga 21061 cttaaaatgc caacgaccca cttcttataa ctggggtcat gaggtcaact taaataaggc 21121 atcagcttgc ctggcacagg cagtggtgat ggtgaggatg tctggttgta agagaactga 21181 cagtggggga aagaggggtt catccttagg tcctgatgag gagctctgac ccccgcctct 21241 tctctctcct cctctccagc tctgattgtg ggtggcatcg tgggcatcct ctttgccgtc 21301 ttcctgatcc tactgctcat gtaccgtatg aagaagaagg atgaaggcag ctatgacctg 21361 ggcaagaaac ccatctacaa gaaagccccc accaatgagt tctacgcgtg aagcttgctt 21421 gtgggcactg gcttggactt tagcggggag ggaagccagg ggattttgaa gggtggacat 21481 tagggtaggg tgaggtcaac ctaatactga cttgtcagta tctccagctc tgattacctt 21541 tgaagtgttc agaagagaca ttgtcttcta ctgttctgcc aggttcttct tgagctttgg 21601 gcctcagttg ccctggcaga aaaatggatt caacttggcc tttctgaagg caagactggg 21661 attggatcac ttcttaaact tccagttaag aatctaggtc cgccctcaag cccatactga 21721 ccatgcctca tccagagctc ctctgaagcc agggggctaa cggatgttgt gtggagtcct 21781 ggctggaggt cctcccccag tggccttcct cccttccttt cacagccggt ctctctgcca 21841 ggaaatgggg gaaggaacta gaaccacctg caccttgaga tgtttctgta aatgggtact 21901 tgtgatcaca ctacgggaat ctctgtggta tatacctggg gccattctag gctctttcaa 21961 gtgacttttg gaaatcaacc ttttttattt gggggggagg atggggaaaa gagctgagag 22021 tttatgctga aatggattta tagaatattt gtaaatctat ttttagtgtt tgttcgtttt 22081 tttaactgtt cattcctttg tgcagagtgt atatctctgc ctgggcaaga gtgtggaggt 22141 gccgaggtgt cttcattctc tcgcacattt ccacagcacc tgctaagttt gtatttaatg 22201 gtttttgttt ttgtttttgt ttgtttcttg aaaatgagag aagagccgga gagatgattt 22261 ttattaattt tttttttttt tttttttttt tactatttat agctttagat agggcctccc 22321 ttcccctctt ctttctttgt tctctttcat taaacccctt ccccagtttt tttttatact 22381 ttaaaccccg ctcctcatgg ccttggccct ttctgaagct gcttcctctt ataaaatagc 22441 ttttgccgaa acatagtttt tttttagcag atcccaaaat ataatgaagg ggatggtggg 22501 atatttgtgt ctgtgttctt ataatatatt attattcttc cttggttcta gaaaaataga 22561 taaatatatt tttttcagga aatagtgtgg tgtttccagt ttgatgttgc tgggtggttg 22621 agtgagtgaa ttttcatgtg gctgggtggg tttttgcctt tttctcttgc cctgttcctg 22681 gtgccttctg atggggctgg aatagttgag gtggatggtt ctaccctttc tgccttctgt 22741 ttgggaccca gctggtgttc tttggtttgc tttcttcagg ctctagggct gtgctatcca 22801 atacagtaac cacatgcggc tgtttaaagt taagccaatt aaaatcacat aagattaaaa 22861 attccttcct cagttgcact aaccacgttt ctagaggcgt cactgtatgt agttcatggc 22921 tactgtactg acagcgagag catgtccatc tgttggacag cactattcta gagaactaaa 22981 ctggcttaac gagtcacagc ctcagctgtg ctgggacgac ccttgtctcc ctgggtagga 23041 ggggggggaa tgggggaggg ctgatgaggc cccagctggg gcctgttgtc tgggaccctc 23101 cctctcctga gaggggaggc ctggtggctt agcctgggca ggtcgtgtct cctcctgacc 23161 ccagtggctg cggtgagggg aaccaccctc ccttgctgca ccagtggcca ttagctcccg 23221 tcaccactgc aacccagggt cccagctggc tgggtcctct tctgccccca gtgcccttcc 23281 ccttgggctg tgttggagtg agcacctcct ctgtaggcac ctctcacact gttgtctgtt 23341 actgattttt tttgataaaa agataataaa acctggtact ttctaaactg cttgcctctg 23401 tcattttcgt tcataacaag tcatcctttt tgggctctgt atccccttga tctcagtgga 23461 gcatgaagaa actccccgga ccaaatcccc tacgggtgcc agacatgccg ggggtgggca 23521 gagggtgggg gcagagaggt aagaaggcag gaaggggcct agagaagagg gaagacttca 23581 gaacatgcac cctgatggcc tatgcagcat atcaccccta cttcaaggtt ttgtttaggt 23641 ggcactgtgt ttaaatagca aacacaaaaa tctttgcgtc agttgccatc catagaaatc 23701 aggaggtttc acataaaaat ccagatttct cacttttctt gggaaaaaga aataaaaaaa 23761 attggcaact gtcagcctgc atggcaacaa gagagctgct gagtggcagg cacccatcta 23821 ga //