LOCUS HUMTHROMA 6163 bp DNA PRI 29-JAN-1995 DEFINITION Human thrombopoietin gene, complete cds. ACCESSION L36051 NID g533214 KEYWORDS thrombopoietin. SOURCE Homo sapiens DNA. ORGANISM Homo sapiens Eukaryotae; mitochondrial eukaryotes; Metazoa; Chordata; Vertebrata; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 6163) AUTHORS Foster,D.C., Sprecher,C.A., Grant,F.J., Kramer,J.M., Kuijper,J.L., Holly,R.D., Whitmore,T.E., Heipel,M.D., Bell,L.A.N., Ching,A.F., McGrane,V., Hart,C., O'Hara,P.J. and Lok,S. TITLE Human thrombopoietin: gene structure, cDNA sequence, expression, and chromosomal localization JOURNAL Proc. Natl. Acad. Sci. U.S.A. 91 (26), 13023-13027 (1994) MEDLINE 95108091 FEATURES Location/Qualifiers source 1..6163 /organism="Homo sapiens" /db_xref="taxon:9606" exon <1..158 /number=1 intron 159..1826 /number=1 exon 1827..1984 /number=2 CDS join(1972..1984,2216..2343,2630..2716,4649..4816, 5053..5718) /codon_start=1 /product="thrombopoietin" /db_xref="PID:g533215" /translation="MELTELLLVVMLLLTARLTLSSPAPPACDLRVLSKLLRDSHVLH SRLSQCPEVHPLPTPVLLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQL GPTCLSSLLGQLSGQVRLLLGALQSLLGTQLPPQGRTTAHKDPNAIFLSFQHLLRGKV RFLMLVGGSTLCVRRAPPTTAVPSRTSLVLTLNELPNRTSGLLETNFTASARTTGSGL LKWQQGFRAKIPGLLNQTSRSLDQIPGYLNRIHELLNGTRGLFPGPSRRTLGAPDISS GTSDTGSLPPNLQPGYSPSPTHPPTGQYTLFPLPPTLPTPVVQLHPLLPDPSAPTPTP TSPLLNTSYTHSQNLSQEG" intron 1985..2215 /number=2 exon 2216..2343 /number=3 intron 2344..2629 /number=3 exon 2630..2716 /number=4 intron 2717..4648 /number=4 exon 4649..4816 /number=5 intron 4817..5052 /number=5 exon 5053..>6163 /number=6 BASE COUNT 1524 a 1706 c 1435 g 1498 t ORIGIN 1 tggggtctcc cccctctgtg tggggagaag tgtgccagag agacgcatgt cctcctcctg 61 tggaggggct gttctccacc accacatgtc ttcctaccaa tctgctcccc agagggctgc 121 ctgctgtgca cttgggtcct ggagcccttc tccacccggt gagtggccag cagggtgtgg 181 ggttatgtga gggtagaaag gacagcaaag agaaatggcc tcccagctgg gggaggggca 241 ggcaaactgg aacctacagg cactgacctt tgtcgagaag agtgtagcct tcccagaatg 301 ggaggagcag ggcagagcag gggtaggggg tggggtgctg ttttctgagg gactgatcac 361 ttacttggtg gaatacagca cagccctggc tggccctaag gaaaggggac atgagcccag 421 ggagaaaata agagagggag ctgcacttag ggcttagcaa acacagtagt aagatggaca 481 cagccccaat ccccattctt agctggtcat tcctcgttag cttaaggttc tgaatctggt 541 gctggggaag ctgggccagg caagccaggg cgcaaggaga gggtaatggg aggaggccca 601 ctcatgttga cagacctaca ggaaatccca atattgaatc aggtgcaagc ctctttgcac 661 aacttgtgaa aggaggagga agccatgtgg ggggtcctgt gaaggaaccg gaaggggttc 721 tgccaagggg gcagggaggc aggtgtgatc tatgagacag atatgttagt gggcgcctaa 781 gacaaggtaa gcccctaagg tgggcatcac ccagcaggtg cccgttcctg ggcagctggt 841 ctcaggaagg aagtcccaga actgttagcc catctcttgg cctcagataa tggagtattt 901 caggacttgg agtccagaga aaagctccag tggctttatg tgtgggggta gatagggaaa 961 gatagaggtt aatttctccc ataccgcctt ttaatcctga cctctagtgg tcccagttac 1021 agctttgtgc agttcccctc cccagcccca ctccccaccg cagaagttac ccctcaacat 1081 attgcgcccg tttgccagtt cctcacccag gccctgcatc ccattttcca ctctcttctc 1141 caggctgaag ccacaatact ttccttctct atccccatcc cagattttct ctgacctaac 1201 aaccaaggtt gctcagaatt taaggctaat taagatatgt gtgtatacat atcatgtcct 1261 gctgctctca gcaggggtag gtggcaccaa atccatgtcc gattcactga ggagtcctga 1321 caaaaaggag acaccatatg ctttcttgct ttctttcttt ctttctttct ttcttttttt 1381 tttttgagac ggagtttcac tcttattgcc caggctggag tgcaatggtg cgatctcggc 1441 tcaccacaac ctccgcctcc caggtacaag cgattctcct gtctcagcct cccaagtagc 1501 ttggattaca ggcatgaacc accacaccct gctagttttt ttgtatttcg tagagccggg 1561 gtttcaccat gttagtgagg ctggtggcga actcctgacc tcaggtgatc cacccgcctt 1621 ggactcccaa agtgctggga ttacaggcat gagccactgc acccggcaca ccatatgctt 1681 tcatcacaag aaaatgtgag agaattcagg gctttggcag ttccaggctg gtcagcatct 1741 caagccctcc ccagcatctg ttcaccctgc caggcagtct cttcctagaa acttggttaa 1801 atgttcactc ttcttgctac tttcaggata gattcttcac ccttggtccg cctttgcccc 1861 accctactct gcccagaagt gcaagagcct aagccgcctc catggcccca ggaaggattc 1921 aggggagagg ccccaaacag ggagccacgc cagccagaca ccccggccag aatggagctg 1981 actggtgaga acacacctga ggggctaggg ccatatggaa acatgacaga aggggagaga 2041 gaaaggagac acgctgcagg gggcaggaag ctgggggaac ccattctccc aaaaataagg 2101 ggtctgaggg gtggattccc tgggtttcag gtctgggtcc tgaatgggaa ttcctggaat 2161 accagctgac aatgatttcc tcctcatctt tcaacctcac ctctcctcat ctaagaattg 2221 ctcctcgtgg tcatgcttct cctaactgca aggctaacgc tgtccagccc ggctcctcct 2281 gcttgtgacc tccgagtcct cagtaaactg cttcgtgact cccatgtcct tcacagcaga 2341 ctggtgagaa ctcccaacat tatccccttt atccgcgtaa ctggtaagac acccatactc 2401 ccaggaagac accatcactt cctctaactc cttgacccaa tgactattct tcccatattg 2461 tccccaccta ctgatcacac tctctgacaa ggattattct tcacaataca gcccgcattt 2521 aaaagctctc gtctagagat agtactcatg gaggactagc ctgcttatta ggctaccata 2581 gctctctcta tttcagctcc cttctccccc caccaatctt tttcaacaga gccagtgccc 2641 agaggttcac cctttgccta cacctgtcct gctgcctgct gtggacttta gcttgggaga 2701 atggaaaacc cagatggtaa gaaagccatc cctaaccttg gcttccctaa gtcctgtctt 2761 cagtttccca ctgcttccca tggattctcc aacattcttg agctttttaa aaatatctca 2821 ccttcagctt ggccacccta acccaatcta cattcaccta tgatgatagc ctgtggataa 2881 gatgatggct tgcaggtcca atatgtgaat agatttgaag ctgaacacca tgaaaagctg 2941 gagagaaatc gctcatggcc atgcctttga cctattcccg ttcagtcttc ttaaattggc 3001 atgaagaagc aagactcata tgtcatccac agatgacaca aagctgggaa gtaccactaa 3061 aataacaaaa gactgaatca agattcaaat cactgaaaga ctaggtcaaa aacaaggtga 3121 aacaacagag atataaactt ctacatgtgg gccgggggct cacgcctgta atcccagcac 3181 tttgggaggc cgaggcaggc agatcacctg agggcaggag tttgagagca gcctggccaa 3241 catggcgaaa ccccgtctct actaagaata cagaattagc cgggcatggt agtgcatgcc 3301 tgtaatccca gctacttgga aggctgaagc aggagaatcc cttgaaccca ggaggtggag 3361 gttgtagtga gctgagatca tgccaatgca ctccagcctg ggtgacaaga gcaaaactcc 3421 gtctcaaaaa gaaaaaaaaa ttctacatgt gtaaattaat gagtaaagtc ctattccagc 3481 tttcaggcca caatgccctg cttccatcat ttaagcctct ggccctagca cttcctacga 3541 aaaggatctg agagaattaa attgccccca aacttaccat gtaacattac tgaagctgct 3601 attcttaaag ctagtaattc ttgtctgttt gatgtttagc atccccattg tggaaatgct 3661 cgtacagaac tctattccga gtggactaca cttaaatata ctggcctgaa caccggacat 3721 ccccctgaag acatatgcta atttattaag agggaccata ttaaactaac atgtgtctag 3781 aaagcagcag cctgaacaga aagagactag aagcatgttt tatgggcaat agtttaaaaa 3841 actaaaatct atcctcaaga accctagcgt cccttcttcc ttcaggactg agtcagggaa 3901 gaagggcagt tcctatgggt cccttctagt cctttctttt catccttatg atcattatgg 3961 tagagtctca tacctacatt tagtttattt attattatta tttgagacgg agtctcactc 4021 tatcccccag gctggagtgc agtggcatga tctcaactca ctgcaacctc agcctcccgg 4081 attcaagcga ttctcctgtc tcagtctccc aagtagctgg gattacaggt gcccaccacc 4141 atgcccagct aatttgtgta tttgtggtag agatggggtt tcaccatgtt gggcaggctg 4201 atcttgaact cctgacctca ggtgatccac ctgcctcagc ctcccaaagt gctgggatta 4261 caggcgtgag ccactgcacc cagccttcat tcagtttaaa aatcaaatga tcctaaggtt 4321 ttgcagcaga aagagtaaat ttgcagcact agaaccaaga ggtaaaagct gtaacagggc 4381 agatttcagc aacgtaagaa aaaaggagct cttctcactg aaaccaagtg taagaccagg 4441 ctggactaga ggacacggga gtttttgaag cagaggctga tgaccagctg tcgggagact 4501 gtgaaggaat tcctgccctg ggtgggacct tggtcctgtc cagttctcag cctgtatgat 4561 tcactctgct ggctactcct aaggctcccc acccgctttt agtgtgccct ttgaggcagt 4621 gcgcttctct cttccatctc tttctcagga ggagaccaag gcacaggaca ttctgggagc 4681 agtgaccctt ctgctggagg gagtgatggc agcacgggga caactgggac ccacttgcct 4741 ctcatccctc ctggggcagc tttctggaca ggtccgtctc ctccttgggg ccctgcagag 4801 cctccttgga acccaggtaa gtccccagtc aagggatctg tagaaactgt tcttttctga 4861 ctcagtcccc ctagaagacc tgagggaaga agggctcttc cagggagctc aagggcagaa 4921 gagctgatct actaagagtg ctccctgcca gccacaatgc ctgggtactg gcatcctgtc 4981 tttcctactt agacaaggga ggcctgagat ctggccctgg tgtttggcct caggaccatc 5041 ctctgccctc agcttcctcc acagggcagg accacagctc acaaggatcc caatgccatc 5101 ttcctgagct tccaacacct gctccgagga aaggtgcgtt tcctgatgct tgtaggaggg 5161 tccaccctct gcgtcaggcg ggccccaccc accacagctg tccccagcag aacctctcta 5221 gtcctcacac tgaacgagct cccaaacagg acttctggat tgttggagac aaacttcact 5281 gcctcagcca gaactactgg ctctgggctt ctgaagtggc agcagggatt cagagccaag 5341 attcctggtc tgctgaacca aacctccagg tccctggacc aaatccccgg atacctgaac 5401 aggatacacg aactcttgaa tggaactcgt ggactctttc ctggaccctc acgcaggacc 5461 ctaggagccc cggacatttc ctcaggaaca tcagacacag gctccctgcc acccaacctc 5521 cagcctggat attctccttc cccaacccat cctcctactg gacagtatac gctcttccct 5581 cttccaccca ccttgcccac ccctgtggtc cagctccacc ccctgcttcc tgacccttct 5641 gctccaacgc ccacccctac cagccctctt ctaaacacat cctacaccca ctcccagaat 5701 ctgtctcagg aagggtaagg ttctcagaca ctgccgacat cagcattgtc tcgtgtacag 5761 ctcccttccc tgcagggcgc ccctgggaga caactggaca agatttccta ctttctcctg 5821 aaacccaaag ccctggtaaa agggatacac aggactgaaa agggaatcat ttttcactgt 5881 acattataaa ccttcagaag ctattttttt aagctatcag caatactcat cagagcagct 5941 agctctttgg tctattttct gcagaaattt gcaactcact gattctcaac atgctctttt 6001 tctgtgataa ctctgcaaag acctgggctg gcctggcagt tgaacagagg gagagactaa 6061 ccttgagtca gaaaacagag gaagggtaat ttcctttgct tcaaattcaa ggccttccaa 6121 cgcccccatc ccctttacta tcattctcag tgggactctg atc //